Cluster of spliceosome complex genes that were significantly altered in response to HAL-PDT

<p><b>Copyright information:</b></p><p>Taken from "Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate"</p><p>http://www.biomedcentral.com/1471-2164/8/273</p><p>BMC Genomics 2007;8():273-273.</p><p>Published online 13 Aug 2007</p><p>PMCID:PMC2045114.</p><p></p> Horizontal stripes represent genes and columns show treatment protocols. The log2-fold changes of gene ratios are color coded as shown in the bar. The three different columns represent repeated microarray experiments

Verification of MYC, ATF3 and JUN expression after HAL-PDT by Western blotting

<p><b>Copyright information:</b></p><p>Taken from "Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate"</p><p>http://www.biomedcentral.com/1471-2164/8/273</p><p>BMC Genomics 2007;8():273-273.</p><p>Published online 13 Aug 2007</p><p>PMCID:PMC2045114.</p><p></p> Cell extracts were prepared at at 1 h, 2 h and 4 h after HAL-PDT (A). Since PDT affected the expression of well-known house keeping proteins such actin (induced) and tubulin (repressed) the total protein content was measured and the gels were stained after electrophoresis, thus normalize against total protein content. The fold-changes obtained by the microarray analysis for the selected genes are presented for comparison. Fold-change of three repeated experiments presented as the mean ± St. Dev (B)

Venn diagrams of differentially altered genes/probes in response to HAL-PDT

<p><b>Copyright information:</b></p><p>Taken from "Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate"</p><p>http://www.biomedcentral.com/1471-2164/8/273</p><p>BMC Genomics 2007;8():273-273.</p><p>Published online 13 Aug 2007</p><p>PMCID:PMC2045114.</p><p></p> A, includes up-regulated and down-regulated; B, only up-regulated; C, only down-regulated genes/probes at 1, 2 and 4 h time course. Each circle represents one time point as indicated. A total number of differentially expressed genes in the group are given in the parentheses. The intersections indicate numbers of genes/probe that are shared between the different time points, i.e. the genes that were steady induced. The number in the right bottom of each square indicates a total post processed and analyzed number of genes/probes minus the number of differentially expressed genes presented in circles