Achieving enterprise integration through software customization: part I - evidence from the field

Achieving business and IT integration is strategic goal for many organisations – it has almost become the ‘Holy Grail’ of organisational success. In this environment Enterprise Resource Planning (ERP) packages have become the defacto option for addressing this issue. Integration has come to mean adopting ERP, through configuration and without customization, but this all or nothing approach has proved difficult for many organisations. In part 1 of a 2 part update we provide evidence from the field that suggests that whilst costly, if managed appropriately, customization can have value in aiding organisational integration efforts. In part 2, we discuss in more detail the benefits and pitfalls involved in enacting a non-standard based integration strategy

Sustainability

In the face of climate change, overflowing landfills, water shortages, and exploitation of natural resources, it is becoming increasingly important to act in responsible and sustainable ways. Environmental sustainability is the intersection of social, economic and environmental solutions to address issues threatening the world we live in. Too often in our society, sustainability is not prioritized and becomes an afterthought. In this case study, we challenge students to explore ways to make our world more sustainable, bringing these important issues into the consciousness of the next generation. In this case study, students can choose the topic they wish to study and do original research. Students will then communicate their original conclusions outside the classroom. By creating their own research and having a product leave the classroom, students will be invested in their work and feel like they are contributing to the global conversation about sustainability. Recommended Citation: Carey, Dominique Kiki, Corrine Losch, Rebecca Howard, Erica Light, and Stephanie Purington. Sustainability Scholarworks. scholarworks.umass.edu. Case Study Lesson Plans for Teachers., July 2016. Web. http://scholarworks.umass.edu/icons_casestudy_gallery/1/ .https://scholarworks.umass.edu/icons_casestudy_gallery/1000/thumbnail.jp

Ocean Acidification

It is hard to imagine that, as humans, we could significantly change the vast expanses of the open ocean. However, as we release more and more carbon dioxide into the atmosphere, it diffuses into the oceans, making them increasingly more acidic. Ocean acidification is often described as the lesser known twin of climate change. A drop in pH could endanger shelled organisms, change fish behavior and have unpredictable consequences on countless other species as well as our own society. Ocean acidification has the potential to cause devastating changes, so it is critical that we all develop more awareness of it. In this case study, students can choose the topic they wish to study and do original research. Students will then communicate their original conclusions outside the classroom. By creating their own research and having a product leave the classroom, students will be invested in their work and feel like they are contributing to the global conversation about ocean acidification. Recommended citation: Carey, Dominique Kiki, Corrine Losch, Rebecca Howard, Erica Light, and Stephanie Purington. Ocean Acidification Scholarworks. scholarworks.umass.edu. Case Study Lesson Plans for Teachers., July 2016. Web. http://scholarworks.umass.edu/icons_casestudy_gallery/3/.https://scholarworks.umass.edu/icons_casestudy_gallery/1002/thumbnail.jp

Oil Spills

While the global market is still highly dependent on oil and fossil fuels, society must be aware of the dangers and repercussions of mishandling of this oil. Oil spills are too often forgotten about after the original media rush, and conversations about cleanup methods are neglected. In this case study, we have students to look into the ramifications of an important oil spill, the Deepwater Horizon oil spill in 2010. We challenge students to look into possible cleanup solutions for oil spills in order to encourage critical thought around an issue that is common in today’s world. In this case study, students can choose the topic they wish to study and do original research. Students will then communicate their original conclusions outside the classroom. By creating their own research and having a product leave the classroom, students will be invested in their work and feel like they are contributing to the global conversation about oil spills. Recommended Citation: Carey, Dominique Kiki, Corrine Losch, Rebecca Howard, Erica Light, and Stephanie Purington. Oil Spills Scholarworks. scholarworks.umass.edu Case Study Lesson Plans for Teachers., July 2016. Web. http://scholarworks.umass.edu/icons_casestudy_gallery/2/.https://scholarworks.umass.edu/icons_casestudy_gallery/1001/thumbnail.jp

Antibiotic Resistance

Many people think that a world without antibiotics is a thing of the past, but we are on the cusp of becoming a generation without cures to the simplest bacterial infections. The more often we expose bacteria to antibiotics, the higher the chance of resistance to the drug forming. In today’s society, where any health issue is met with a drug and livestock are being pumped full of antibiotics, more infections are growing resistant to the drugs we use to combat them. Students will investigate the current situation, find solutions to the waning effectiveness of antibiotics, and encourage a behavioral change in society. In this case study, students can choose the topic they wish to study and do original research. Students will then communicate their original conclusions outside the classroom. By creating their own research and having a product leave the classroom, students will be invested in their work and feel like they are contributing to the global conversation about antibiotic resistance. Recommended citation: Carey, Dominique Kiki, Corrine Losch, Rebecca Howard, Erica Light, and Stephanie Purington. Antibiotic Resistance Scholarworks. scholarworks.umass.edu. Case Study Lesson Plans for Teachers., July 2016. Web. http://scholarworks.umass.edu/icons_casestudy_gallery/4/.https://scholarworks.umass.edu/icons_casestudy_gallery/1003/thumbnail.jp

Between-site reliability of startle prepulse inhibition across two early psychosis consortia

Prepulse inhibition (PPI) and reactivity of the acoustic startle response are widely used biobehavioral markers in psychopathology research. Previous studies have demonstrated that PPI and startle reactivity exhibit substantial within-site stability; between-site stability, however, has not been established. In two separate consortia investigating biomarkers of early psychosis, traveling subjects studies were performed as part of quality assurance procedures in order to assess the fidelity of data across sites. In the North American Prodromal Longitudinal Studies (NAPLS) Consortium, 8 normal subjects traveled to each of the 8 NAPLS sites and were tested twice at each site on the startle PPI paradigm. In preparation for a binational study, 10 healthy subjects were assessed twice in both San Diego and Mexico City. Intraclass correlations between and within sites were significant for PPI and startle response parameters, confirming the reliability of startle measures across sites in both consortia. There were between site differences in startle magnitude in the NAPLS study that did not appear to be related to methods or equipment. In planning multi-site studies, it is essential to institute quality assurance procedures early and establish between site reliability to assure comparable data across sites

“Because it was cheap, because it was on sale”: Essential nutrient intake at USU

The “freshman 15” is common folklore on college campuses. So too is the understanding that ramen and pizza are the breakfast, lunch, and dinner of champions and that Mountain Dew with a shot of Monster is the elixir of life. In this poster, we will seek to identify in what ways essential nutrient intake differs between college classes (e.g. freshmen, sophomores, etc.) at Utah State University, focusing specifically on water soluble vitamins. We used a convenient snowballing sample to conduct a 24 hour food recall with 5-8 participants per college class. Additionally, each interview included basic demographic information that we believed could impact nutritional intake: Employment status, income, gender, residency (on or off campus), meal plan, marital status, number of children, religious identity, transportation access, and the number of credits that each participant is currently taking, as well as height, weight, and age. Water soluble vitamins are constantly flushed from the body, thus they need to be replaced daily. For this reason, students should be eating foods that contain these vitamins every day. We utilized the USDA Food and Nutrient Database for Dietary Studies (FNDDS) dataset to calculate water-soluable vitamin values for each participant based upon their 24 hour diet recalls. We then entered these values into SPSS and compared to see whether they differed significantly from the recommended dietary allowance (RDA) for each participant’s age and gender. Where RDA values are not available we used adequate intake (AI) values. Because participant observation is an integral part of any anthropological study, we also accompanied and observed participants when they went to the grocery store, to understand what factors went into choosing foods

Effects of Amphetamine on Sensorimotor Gating and Neurocognition in Antipsychotic-Medicated Schizophrenia Patients.

Prepulse inhibition (PPI) of startle is being explored both as an indicator of target engagement for, and a biomarker predicting the sensitivity to, procognitive effects of drugs. We now report the effects of the pro-attentional drug, d-amphetamine, on PPI and neurocognition in antipsychotic-medicated schizophrenia patients and healthy subjects (HS) who were also tested in a targeted cognitive training (TCT) module. 44 HS and 38 schizophrenia patients completed a double-blind, placebo-controlled crossover study of the effects of a single dose of amphetamine (10 mg po) on PPI and MATRICS Consensus Cognitive Battery (MCCB) performance; TCT results were previously reported from 60 of these subjects. Moderators predicting AMPH sensitivity were assessed, including the rs4680 single-nucleotide polymorphism for catechol-O-methyltransferase (COMT). After placebo, patients exhibited PPI deficits with 60 ms prepulse intervals; these deficits were 'rescued' by amphetamine. The magnitude of amphetamine-enhanced PPI was greater in patients than in HS (p<0.032), and was associated with positive symptoms (p<0.007), antipsychotic load (p<0.015), hedonic effects of AMPH (p<0.003), and with the presence of at least one methionine allele in rs4680 (p<0.008). No significant effects of amphetamine on MCCB performance were detected in either group, though pro-attentional effects of amphetamine in patients were associated with greater amphetamine-enhanced TCT learning. Amphetamine acutely 'normalized' PPI in antipsychotic-medicated schizophrenia patients; no concurrent acute neurocognitive changes were detected by the MCCB. Findings suggest that in the context of appropriate antipsychotic medication, a low dose of amphetamine enhances brain processes associated with higher function in schizophrenia patients, without accompanying changes in MCCB performance

Effects of Amphetamine on Sensorimotor Gating and Neurocognition in Antipsychotic-Medicated Schizophrenia Patients.

Prepulse inhibition (PPI) of startle is being explored both as an indicator of target engagement for, and a biomarker predicting the sensitivity to, procognitive effects of drugs. We now report the effects of the pro-attentional drug, d-amphetamine, on PPI and neurocognition in antipsychotic-medicated schizophrenia patients and healthy subjects (HS) who were also tested in a targeted cognitive training (TCT) module. 44 HS and 38 schizophrenia patients completed a double-blind, placebo-controlled crossover study of the effects of a single dose of amphetamine (10 mg po) on PPI and MATRICS Consensus Cognitive Battery (MCCB) performance; TCT results were previously reported from 60 of these subjects. Moderators predicting AMPH sensitivity were assessed, including the rs4680 single-nucleotide polymorphism for catechol-O-methyltransferase (COMT). After placebo, patients exhibited PPI deficits with 60 ms prepulse intervals; these deficits were 'rescued' by amphetamine. The magnitude of amphetamine-enhanced PPI was greater in patients than in HS (p<0.032), and was associated with positive symptoms (p<0.007), antipsychotic load (p<0.015), hedonic effects of AMPH (p<0.003), and with the presence of at least one methionine allele in rs4680 (p<0.008). No significant effects of amphetamine on MCCB performance were detected in either group, though pro-attentional effects of amphetamine in patients were associated with greater amphetamine-enhanced TCT learning. Amphetamine acutely 'normalized' PPI in antipsychotic-medicated schizophrenia patients; no concurrent acute neurocognitive changes were detected by the MCCB. Findings suggest that in the context of appropriate antipsychotic medication, a low dose of amphetamine enhances brain processes associated with higher function in schizophrenia patients, without accompanying changes in MCCB performance

Amphetamine Enhances Gains in Auditory Discrimination Training in Adult Schizophrenia Patients.

Targeted cognitive training (TCT) of auditory processing enhances higher-order cognition in schizophrenia patients. TCT performance gains can be detected after 1 training session. As a prelude to a potential clinical trial, we assessed a pharmacological augmentation of cognitive therapy (PACT) strategy by testing if the psychostimulant, amphetamine, augments TCT gains in auditory processing speed (APS) in schizophrenia patients and healthy subjects (HS). HS and schizophrenia patients were tested in a screening session (test 1), followed by a double-blind crossover design (tests 2-3), comparing placebo vs amphetamine (10 mg; 7 d between tests). On each test day, 1 hour of Posit Science "Sound Sweeps" training was bracketed by 2- to 4-minute pre- and post-training assessments of APS. Training consisted of a speeded auditory time-order judgment task of successive frequency modulation sweeps. Auditory system "learning" (APS post- vs pre-training) was enhanced by amphetamine (main effect of drug: P < .002; patients: d = 0.56, P < .02; HS: d = 0.39, nonsignificant), and this learning was sustained for at least 1 week. Exploratory analyses assessed potential biomarker predictors of sensitivity to these effects of amphetamine. Amphetamine enhances auditory discrimination learning in schizophrenia patients. We do not know whether gains in APS observed in patients after 1 hour of TCT predict clinical benefits after a full course of TCT. If amphetamine can enhance the therapeutic effects of TCT, this would provide strong support for a "PACT" treatment paradigm for schizophrenia