Section 66A and free speech in India: the debate continues

Olina Banerji explains why digital rights and free speech activists in India believe Section 66A of the Information Technology Act to be unconstitutional

COOL-LAMPS. VII. Quantifying Strong-lens Scaling Relations with 177 Cluster-scale Gravitational Lenses in DECaLS

We compute parametric measurements of the Einstein-radius-enclosed total mass for 177 cluster-scale strong gravitational lenses identified by the ChicagO Optically-selected Lenses Located At the Margins of Public Surveys (COOL-LAMPS) collaboration with lens redshifts ranging from $0.2 \lessapprox z \lessapprox 1.0$ using only two measured parameters in each lensing system: the Einstein radius, and the brightest-cluster-galaxy (BCG) redshift. We then constrain the Einstein-radius-enclosed luminosity and stellar mass by fitting parametric spectral energy distributions (SEDs) with aperture photometry from the Dark Energy Camera Legacy Survey (DECaLS) in the $g$, $r$, and $z$-band Dark Energy Camera (DECam) filters. We find that the BCG redshift, enclosed total mass, and enclosed luminosity are strongly correlated and well described by a planar relationship in 3D space. We also find that the enclosed total mass and stellar mass are correlated with a logarithmic slope of $0.443\pm0.035$, and the enclosed total mass and stellar-to-total mass fraction are correlated with a logarithmic slope of $-0.563\pm0.035$. The correlations described here can be used to validate strong lensing candidates in upcoming imaging surveys -- such as Rubin/Legacy Survey of Space and Time (LSST) -- in which an algorithmic treatment of lensing systems will be needed due to the sheer volume of data these surveys will produce.Comment: 17 pages, 5 figures, 2 tables. Submitted to The Astrophysical Journal. v3: updated authors, formatting, grammar, and reference

Abnormal Neurites Containing C-Terminally Truncated α-Synuclein Are Present in Alzheimer’s Disease without Conventional Lewy Body Pathology

The pathological hallmark of Parkinson’s disease and diffuse Lewy body disease (DLBD) is the aggregation of α-synuclein (α-syn) in the form of Lewy bodies and Lewy neurites. Patients with both Alzheimer’s disease (AD) and cortical Lewy pathology represent the Lewy body variant of AD (LBV) and constitute 25% of AD cases. C-terminally truncated forms of α-syn enhance the aggregation of α-syn in vitro. To investigate the presence of C-terminally truncated α-syn in DLBD, AD, and LBV, we generated and validated polyclonal antibodies to truncated α-syn ending at residues 110 (α-syn110) and 119 (α-syn119), two products of 20S proteosome-mediated endoproteolytic cleavage. Double immunofluorescence staining of the cingulate cortex showed that α-syn110 and α-syn140 (full-length) aggregates were not colocalized in LBV. All aggregates containing α-syn140 also contained α-syn119; however, some aggregates contained α-syn119 without α-syn140, suggesting that α-syn119 may stimulate aggregate formation. Immunohistochemistry and image analysis of tissue microarrays of the cingulate cortex from patients with DLBD (n = 27), LBV (n = 27), and AD (n = 19) and age-matched controls (n = 15) revealed that AD is also characterized by frequent abnormal neurites containing α-syn119. Notably, these neurites did not contain α-syn ending at residues 110 or 122-140. The presence of abnormal neurites containing α-syn119 in AD without conventional Lewy pathology suggests that AD and Lewy body disease may be more closely related than previously thought