Modeling and analyzing the evolution of cellular networks using stochastic geometry

The increasing complexity of cellular network due to its continuous evolution has made the conventional system level simulations time consuming and cost prohibitive. By modeling base station (BS) and user locations as spatial point processes, stochastic geometry has recently been recognized as a tractable and efficient analytical tool to quantify key performance metrics. The goal of this dissertation is to leverage stochastic geometry to develop an accurate spatial point process model for the conventional homogeneous macro cellular network, and to address the design and analysis challenges for the emerging cellular networks that will explore new spectrum for cellular communications. First, this dissertation proposes to use the repulsive determinantal point processes (DPPs) as an accurate model for macro BS locations in a cellular network. Based on three unique computational properties of the DPPs, the exact expressions of several fundamental performance metrics for cellular networks with DPP configured BSs are analytically derived and numerically evaluated. Using hypothesis testing for various performance metrics of interest, the DPPs are validated to be more accurate than the Poisson point process (PPP) or the deterministic grid model. Then the focus of this dissertation shifts to emerging networks that exploit new spectrum for cellular communications. One promising option is to allow the centrally scheduled cellular system to also access the unlicensed spectrum, wherein a carrier sensing multiple access with collision avoidance (CSMA/CA) protocol is usually used, as in Wi-Fi. A stochastic geometry-based analytical framework is developed to characterize the performance metrics for neighboring Wi-Fi and cellular networks under various coexistence mechanisms. In order to guarantee fair coexistence with Wi-Fi, it is shown that the cellular network needs to adopt either a discontinuous transmission pattern or its own CSMA/CA like mechanisms. Next, this dissertation considers cellular networks operating in the millimeter wave (mmWave) band, where directional beamforming is required to establish viable connections. Therefore, a major design challenge is to learn the necessary beamforming directions through the procedures that establish the initial connection between the mobile user and the network. These procedures are referred to as initial access, wherein cell search on the downlink and random access on the uplink are the two major steps. Stochastic geometry is again utilized to develop a unified analytical framework for three directional initial access protocols under a high mobility scenario where users and random blockers are moving with high speed. The expected delay for a user to succeed in initial access, and the average user-perceived downlink throughput that accounts for the initial access overhead, are derived for all three protocols. In particular, the protocol that has low beam-sweeping overhead during cell search is found to achieve a good trade-off between the initial access delay and user-perceived throughput performance. Finally, in contrast to the high mobility scenario for initial access, the directional cell search delay in a slow mobile network is analyzed. Specifically, the BS and user locations are fixed for long period of time, and therefore a strong temporal correlation for SINR is experienced. A closed-form expression for the expected cell search delay is derived, indicating that the expected cell search delay is infinite for noise-limited networks (e.g., mmWave) whenever the non-line-of-sight path loss exponent is larger than 2. By contrast, the expected cell search delay for interference-limited networks is proved to be infinite when the number of beams to search at the BS is smaller than a certain threshold, and finite otherwise.Electrical and Computer Engineerin

Canonical momentum based numerical schemes for hybrid plasma models with kinetic ions and massless electrons

We study the canonical momentum based discretizations of a hybrid model with kinetic ions and mass-less electrons. Two equivalent formulations of the hybrid model are presented, in which the vector potentials are in different gauges and the distribution functions depend on canonical momentum (not velocity). Particle-in-cell methods are used for the distribution functions, and the vector potentials are discretized by the finite element methods in the framework of finite element exterior calculus. Splitting methods are used for the time discretizations. It is illustrated that the second formulation is numerically superior and the schemes constructed based on the anti-symmetric bracket proposed have better conservation properties, although the filters can be used to improve the schemes of the first formulation.Comment: 24 pages, 8 figure

Study on a High-Accuracy Real-Time Algorithm to Estimate SOC of Multiple Battery Cells Simultaneously

In traditional battery equalization strategy, open-circuit voltage (OCV) of battery cells was used to judge the difference of SOC between them. However, OCV is not only determined by SOC but also influenced by internal resistance, polarization voltage, capacity, and other nonlinear factors. As a result, OCV is not an ideal indicator of SOC differences, especially in transient conditions. In order to control battery consistency accurately, it is best to use SOC directly as standard for battery consistency judgment and control. To achieve this, an algorithm that can estimate SOC of multiple battery cells simultaneously with low computational complexity and high accuracy is needed. Limited by computing speed of Battery Control Unit (BCU), existing SOC estimation method is hard to estimate SOC of each battery cell simultaneously with high accuracy. In this research, a new SOC estimation strategy was proposed to estimate SOC of multiple battery cells simultaneously for battery equalization control. Battery model is established based on experimental data, and a processor-in-the-loop test system was established to verify the actual performance of the proposed algorithm. Results of simulation and test indicate that the proposed algorithm can estimate SOC of multiple battery cells simultaneously and achieved good real-time performance and high accuracy

Progress and perspectives of perioperative immunotherapy in non-small cell lung cancer

Lung cancer is one of the leading causes of cancer-related death. Lung cancer mortality has decreased over the past decade, which is partly attributed to improved treatments. Curative surgery for patients with early-stage lung cancer is the standard of care, but not all surgical treatments have a good prognosis. Adjuvant and neoadjuvant chemotherapy are used to improve the prognosis of patients with resectable lung cancer. Immunotherapy, an epoch-defining treatment, has improved curative effects, prognosis, and tolerability compared with traditional and ordinary cytotoxic chemotherapy, providing new hope for patients with non-small cell lung cancer (NSCLC). Immunotherapy-related clinical trials have reported encouraging clinical outcomes in their exploration of different types of perioperative immunotherapy, from neoadjuvant immune checkpoint inhibitor (ICI) monotherapy, neoadjuvant immune-combination therapy (chemoimmunotherapy, immunotherapy plus antiangiogenic therapy, immunotherapy plus radiotherapy, or concurrent chemoradiotherapy), adjuvant immunotherapy, and neoadjuvant combined adjuvant immunotherapy. Phase 3 studies such as IMpower 010 and CheckMate 816 reported survival benefits of perioperative immunotherapy for operable patients. This review summarizes up-to-date clinical studies and analyzes the efficiency and feasibility of different neoadjuvant therapies and biomarkers to identify optimal types of perioperative immunotherapy for NSCLC

Superconductivity above 70 K observed in lutetium polyhydrides

The binary polyhydrides of heavy rare earth lutetium that shares a similar valence electron configuration to lanthanum have been experimentally discovered to be superconductive. The lutetium polyhydrides were successfully synthesized at high pressure and high temperature conditions using a diamond anvil cell in combinations with the in-situ high pressure laser heating technique. The resistance measurements as a function of temperature were performed at the same pressure of synthesis in order to study the transitions of superconductivity (SC). The superconducting transition with a maximum onset temperature (Tc) 71 K was observed at pressure of 218 GPa in the experiments. The Tc decreased to 65 K when pressure was at 181 GPa. From the evolution of SC at applied magnetic fields, the upper critical field at zero temperature {\mu}0Hc2(0) was obtained to be ~36 Tesla. The in-situ high pressure X-ray diffraction experiments imply that the high Tc SC should arise from the Lu4H23 phase with Pm-3n symmetry that forms a new type of hydrogen cage framework different from those reported for previous light rare earth polyhydride superconductors

Metabolomics in the Development and Progression of Dementia: A Systematic Review

Dementia has become a major global public health challenge with a heavy economic burden. It is urgently necessary to understand dementia pathogenesis and to identify biomarkers predicting risk of dementia in the preclinical stage for prevention, monitoring, and treatment. Metabolomics provides a novel approach for the identification of biomarkers of dementia. This systematic review aimed to examine and summarize recent retrospective cohort human studies assessing circulating metabolite markers, detected using high-throughput metabolomics, in the context of disease progression to dementia, including incident mild cognitive impairment, all-cause dementia, and cognitive decline. We systematically searched the PubMed, Embase, and Cochrane databases for retrospective cohort human studies assessing associations between blood (plasma or serum) metabolomics profile and cognitive decline and risk of dementia from inception through October 15, 2018. We identified 16 studies reporting circulating metabolites and risk of dementia, and six regarding cognitive performance change. Concentrations of several blood metabolites, including lipids (higher phosphatidylcholines, sphingomyelins, and lysophophatidylcholine, and lower docosahexaenoic acid and high-density lipoprotein subfractions), amino acids (lower branched-chain amino acids, creatinine, and taurine, and higher glutamate, glutamine, and anthranilic acid), and steroids were associated with cognitive decline and the incidence or progression of dementia. Circulating metabolites appear to be associated with the risk of dementia. Metabolomics could be a promising tool in dementia biomarker discovery. However, standardization and consensus guidelines for study design and analytical techniques require future development