Allergic skin rash with lamotrigine and concomitant valproate therapy - Evidence for an increased risk

Cutaneous rash is one of the commonest adverse events associated with lamotrigine. We assessed whether the risk is increased in patients receiving concomitant valproate therapy in a population of 103 adult patients with intractable epilepsy, who had lamotrigine added to their treatment. Of the 33 patients taking valproate, 10 (30%) developed a rash, whilst of the 70 not taking valproate, only 6 (8%) developed a rash. This suggests a significantly higher risk of cutaneous rash when starting lamotrigine in patients already taking valproate (p<0.02)

Late Paleoproterozoic sedimentary rock-hosted stratiform copper deposits in South China: their possible link to the supercontinent cycle

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Enhanced photocatalytic activity of Ce??-TiO?for 2-mercaptobenzothiazole degradation in aqueous suspension for odour control

Author name used in this publication: F. B. LiAuthor name used in this publication: X. Z. Li2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Photocatalytic conversion of NO using TiO?-NH?catalysts in ambient air environment

Author name used in this publication: F. B. LiAuthor name used in this publication: X. Z. LiAuthor name used in this publication: C. H. AoAuthor name used in this publication: S. C. Lee2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Enhanced photocatalytic degradation of VOCs using Ln??-TiO?catalysts for indoor air purification

Author name used in this publication: F. B. LiAuthor name used in this publication: X. Z. LiAuthor name used in this publication: C. H. AoAuthor name used in this publication: S. C. Lee2004-2005 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Providing clean water to rural villages

The paper is dedicated to investigate the results of a Third Party Validatioin TPV experience in Punjab. The Client, Punjab Saaf Pani Company, the State owned Authority, is allotted the task of providing fresh water to rural village

Feasibility and acceptability of involving bilingual community navigators to improve access to health and social care services in general practice setting of Australia

Background: Patients from culturally and linguistically diverse (CALD) backgrounds often face difficulties in accessing health and social care services. This study explored the feasibility and acceptability of involving community health workers (CHWs) as bilingual community navigators (BCNs) in general practice setting, to help patients from CALD backgrounds access health and social care services in Australia. Methods: This research was conducted in two general practices in Sydney where most patients are from specific CALD backgrounds (Chinese in one practice and Samoan in other). Three CHWs trained as BCNs were placed in these practices to help patients access health and social care service. A mixed-method design was followed to explore the feasibility and acceptability of this intervention including analysis of a record of services provided by BCNs and post-intervention qualitative interviews with patients, practice staff and BCNs exploring the feasibility and acceptability of the BCNs’ role. The record was analyzed using descriptive statistics and interviews were audio-recorded, transcribed, and thematically analyzed. Results: BCNs served a total of 95 patients, providing help with referral to other services (52.6%), information about appointments (46.3%), local resources (12.6%) or available social benefits (23.2%). Most patients received one service from BCNs with the average duration of appointments being half an hour. Overall, BCNs fitted in well within the practices and patients as well as staff of participating practices accepted them well. Their role was facilitated by patients’ felt need for and acceptance of BCNs’ services, recruitment of BCNs from the patient community, as well as BCNs’ training and motivation for their role. Major barriers for patients to access BCNs’ services included lack of awareness of the BCNs’ roles among some patients and practice staff, unavailability of information about local culture specific services, and inadequate time and health system knowledge by BCNs. Limited funding support and the short timeframe of the project were major limitations of the project. Conclusion: BCNs’ placement in general practice was feasible and acceptable to patients and staff in these practices. This first step needs to be followed by accredited training, development of the workforce and establishing systems for supervision in order to sustain the program. Future research is needed on the extension of the intrevention to other practices and culture groups

Late-onset bloodstream infection and perturbed maturation of the gastrointestinal microbiota in premature infants

Late-onset bloodstream infection (LO-BSI) is a common complication of prematurity, and lack of timely diagnosis and treatment can have life-threatening consequences. We sought to identify clinical characteristics and microbial signatures in the gastrointestinal microbiota preceding diagnosis of LO-BSI in premature infants.Daily faecal samples and clinical data were collected over two years from 369 premature neonates (<32 weeks gestation). We analysed samples from 22 neonates who developed LO-BSI and 44 matched control infants. Next-generation sequencing of 16S rRNA gene regions amplified by PCR from total faecal DNA was used to characterise the microbiota of faecal samples preceding diagnosis from infants with LO-BSI and controls. Culture of selected samples was undertaken, and bacterial isolates identified using MALDI-TOF. Antibiograms from bloodstream and faecal isolates were compared to explore strain similarity.From the week prior to diagnosis, infants with LO-BSI had higher proportions of faecal aerobes/facultative anaerobes compared to controls. Risk factors for LO-BSI were identified by multivariate analysis. Enterobacteriaceal sepsis was associated with antecedent multiple lines, low birth weight and a faecal microbiota with prominent Enterobacteriaceae. Staphylococcal sepsis was associated with Staphylococcus OTU faecal over-abundance, and the number of days prior to diagnosis of mechanical ventilation and of the presence of centrally-placed lines. In 12 cases, the antibiogram of the bloodstream isolate matched that of a component of the faecal microbiota in the sample collected closest to diagnosis.The gastrointestinal tract is an important reservoir for LO-BSI organisms, pathogens translocating across the epithelial barrier. LO-BSI is associated with an aberrant microbiota, with abundant staphylococci and Enterobacteriaceae and a failure to mature towards predominance of obligate anaerobes

Tectonic background of the Kuda ophiolite, western Kunlun: new constraints from boninite series rocks

通过对依莎克群火山岩的地球化学研究，首次在西昆仑库地蛇绿岩中发现了玻安岩系岩石。这些岩石具有高SiO2、低TiO2、高Al2O3/TiO2 比值和高Cr 含量，亏损Y 和REE，呈现轻稀土富集的分布模式以及相对低的Ti/Zr 比值和高的Zr/Y 比值。其中一些样品还具有相当于MORB 的Nb、Ta 含量和相应较小的La/Nb 比值，表明在其形成过程中可能有富集地幔端员的介入。玻安岩系岩石的发现以及火山地层序列的岩性变化表明，依莎克群火山岩形成于初始的大洋岛弧或弧后盆地拉张的早期阶段，火山岩的地球化学组成变化以及玻安岩在依莎克群火山序列中的位置表明，原特提斯的消减方向应当是向北的。Preliminary geochemical study is conducted for the Yishake volcanic sequence of Küda ophiolote, West Kunlun, and boninite series rocks are just recognized for the first time in this area. The boninite series rocks are characterized by relatively high SiO2 and Cr, high Al2O3/TiO2 ratios and being very depleted in TiO2, Y and REE. They all exhibit LREE enriched patterns and show low Ti/Zr and high Zr/Y ratios. Some of these samples possess relatively high Nb and Ta contents equivalent to those of MORB and accordingly low …published_or_final_versio

Erythroid differentiation and denucleation factors from fetal rat liver: monoclonal antibodies preparation for clone screening from human bone marrow cDNA library

Abstract no. 3100published_or_final_versio