Autophagy in the Pathogenesis of Disease

Autophagy is a lysosomal degradation pathway that is essential for survival, differentiation, development, and homeostasis. Autophagy principally serves an adaptive role to protect organisms against diverse pathologies, including infections, cancer, neurodegeneration, aging, and heart disease. However, in certain experimental disease settings, the self-cannibalistic or, paradoxically, even the prosurvival functions of autophagy may be deleterious. This Review summarizes recent advances in understanding the physiological functions of autophagy and its possible roles in the causation and prevention of human diseases

Welcome, fellow toastmasters : The history and membership of a public speaking phenomenon

Since 1905, Toastmasters International (TI) serves as the most recognized organization for voluntary oral communication practice in the world. Due to the dearth of scholarly communication research regarding TI, this thesis details the history, educational structure, and program dynamics of the organization. Literature review included the nature and extent of post-secondary communication education, as well as social affiliation and leisure theories. Finally, an Internet survey of 343 international TI members revealed the demographics of the typical TI member: a male or female college graduate between the ages of 36--50, who works in a wide range of professions. The study also indicated that participants mainly join TI for professional purposes or for self-fulfillment. Similarly, participants remain in the organization for personal fulfillment and friendships. The author concluded that TI remains a fertile research area for communication scholars, particularly communication professors\u27 perceptions of the organization, and longitudinal membership studies

Real-time Sentence Processing in Aphasia

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Report: 2022 ALA-CORE National Binding Survey

The American Library Association (ALA) Core Preservation Administration Interest Group (PAIG) held a Symposium on the Future of Library Binding in 2022. Following the symposium, the ALA Core Library Binding Practices Survey Team (hereafter, “Team”) was convened to explore issues that arose during the symposium. The Team members volunteered to create a survey on current library binding practices to gain a better understanding of who is using library binding as a preservation and access method, how they are using such services, and the challenges that face the community

COPI Activity Coupled with Fatty Acid Biosynthesis Is Required for Viral Replication

During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular factors are required, has been unclear. Moreover, the host–pathogen interactions that facilitate the formation of this new compartment might represent critical determinants of viral pathogenesis, and their elucidation may lead to novel insights into the coordination of vesicular trafficking events during infection. Here we show that in Drosophila cells, Drosophila C virus remodels the Golgi apparatus and forms a novel vesicular compartment, on the surface of which viral RNA replication takes place. Using genome-wide RNA interference screening, we found that this step in the viral lifecycle requires at least two host encoded pathways: the coat protein complex I (COPI) coatamer and fatty acid biosynthesis. Our results integrate, clarify, and extend numerous observations concerning the cell biology of viral replication, allowing us to conclude that the coupling of new cellular membrane formation with the budding of these vesicles from the Golgi apparatus allows for the regulated generation of this new virogenic organelle, which is essential for viral replication. Additionally, because these pathways are also limiting in flies and in human cells infected with the related RNA virus poliovirus, they may represent novel targets for antiviral therapies