28,597 research outputs found
The influence of portal blood upon lipid metabolism in normal and diabetic dogs and baboons
It has been reported that hyperlipidemia can be alleviated in human beings with an end to side portacaval shunt. Understanding the mechanism of the effect has important implications, including the possibility of devising other ways of lowering serum lipid levels. In this investigation, the influence of splanchnic venous blood on lipid metabolism was evaluated in dogs and baboons by altering the portal venous inflow to all, or portions, of the liver and by measuring the effects on different end points, including the serum lipid concentrations and the rate of hepatic lipid synthesis. In other studies, analyses have been made regarding the effect of alloxan induced insulinopenia and of total pancreatectomy on these processes. The results indicate that the effect of complete portal diversion upon serum lipids is mainly due to diversion of the hormone rich venous return from the upper splanchnic organs, although the bypass of the nutritionally rich blood returning from the intestines may play a secondary role. Therefore, a reduction of hepatic lipid synthesis is an important, although not necessarily the sole, factor in the antilipidemic influence of portacaval shunt. The effects upon synthesis and blood lipids are due more to the diversion of endogenous hormones than to the bypass of intestinal nutrients. The substances in portal venous blood that subserve hepatic lipid metabolism are presumably largely the same as the hepatotrophic factors which have been described before as profoundly affecting hepatic structure, function, and the capacity for regeneration. These portal blood factors are multiple and interrelated, but the single most important one seems to be insulin
Non-Fermi Liquid behavior at the Orbital Ordering Quantum Critical Point in the Two-Orbital Model
The critical behavior of a two-orbital model with degenerate and
orbitals is investigated by multidimensional bosonization. We find
that the corresponding bosonic theory has an overdamped collective mode with
dynamical exponent , which appears to be a general feature of a
two-orbital model and becomes the dominant fluctuation in the vicinity of the
orbital-ordering quantum critical point. Since the very existence of this
overdamped collective mode induces non-Fermi liquid behavior near the quantum
critical point, we conclude that a two-orbital model generally has a sizable
area in the phase diagram showing non-Fermi liquid behavior. Furthermore, we
show that the bosonic theory resembles the continuous model near the d-wave
Pomeranchuk instability, suggesting that orbital order in a two-orbital model
is identical to nematic order in a continuous model. Our results can be applied
to systems with degenerate and orbitals such as iron-based
superconductors and bilayer strontium ruthenates SrRuO.Comment: 5 pages, 2 figure
從人到書,從書到人 : 對文學課本的反思與期望 = From man to book, and book to man : reflections and expectations towards literary textbooks
作者認為文學是教育中不可缺少的成分,它可説是社會、文化與人的「情感教育」。若果一個社會對文學教育不夠重視,它或會因此而有所缺失,甚至乎會喪失「集體回憶」。不同地區的文學教育的表達或體現可以是多形式,包括獨立課程,如香港,或融入語文課程之內,如內地及台灣。教材出版,則是體現課程、展現課程的工具,用以協助教與學,因此兩者的關係極為密切。已故的出版家及社會語言學家陳原曾著有一書:《書和人和我》(1994),以出版人的身份去談書與人的關係,以及彼此間的種種聯想與抒發。從來出版人的終極關心都是文化和人,作者在此書的啟發下,去思考文學教育的發展,並嘗試借用陳原的説法,從人出發。從人去看書,看人需要怎樣的書;再從書去看人,看書怎樣可形塑人
Toward an Understanding of Contemporary Korean American Piano Music: A Stylistic Analysis of In-transit (1999), Piano Sonata (2006), and Inter-Mez-Zo (2006) by Beata Moon
Beata Moon is a second-generation Korean American musician who is actively involved in the American music field. She is a performing pianist but also serves as a promoter of new music and aesthetic education. As a composer, Moon has developed a distinctive style that is eclectic and accessible to the audience.
The focus of the study is a stylistic analysis of Beata Moon\u27s three major solo piano works: In-Transit (1999), Piano Sonata (2006), and Inter-Mez-Zo (2006). The analysis includes examination of form, harmony, melody, rhythm and keyboard usage in each of Beata Moon\u27s three major solo piano works. This study also provides Moon\u27s biographical information and a transcript of a one-on-one interview
An examination of the decision-making process for utilization of mobile applications in the MICE industry
The present study proposed a theoretical framework to examine consumers\u27 decision-making processes for utilization of mobile applications in the Meetings, Incentives, Conferences, and Exhibitions (MICE) industry. This study combines empirical evidence with constructs that incorporated cognitive and attitudinal variables in the Technology Acceptance Model (TAM), and the habitual, motivational, and emotional variables in the Model of Goal-directed Behavior as related to mobile applications in the MICE industry.
To investigate the conceptual model, data were collected using a web-based survey through Amazon Mechanical Turk. A total of 504 questionnaires were utilized for data analysis. Confirmatory factor analysis was first employed to verify the underlying structure for a set of observed variables. Findings from the measurement model indicated this study\u27s variables included a satisfactory level of reliability and validity. When measures were validated, structural equation modeling (SEM) was used to test the validity of the proposed model and the hypotheses.
Findings from the present study revealed the proposed theoretical framework had a strong ability to anticipate intentions. Complex domains, including cognitive, attitudinal, motivational, habitual, and emotional processes, affected customers\u27 decision-making processes for utilization of mobile applications in the MICE industry. In particular, incorporated antecedent variables in the TAM (i.e., perceived usefulness and perceived ease of use) played a vital role in MICE participants\u27 mobile applications adoption decision formation, and identified attitude and perceived behavioral controls that acted as mediators. Perceived behavioral control regarding MICE mobile application usage had positive effects on desire and intention; whereas, attitudes and positive anticipated emotion have positive effects only on desire. In addition, desire and habit had a positive relationship with consumers\u27 intentions to utilize MICE mobile applications.
The findings of the current study provide significant insights for researchers and MICE organizations. From the theoretical perspective, this study contributes to the theoretical development of behavior formation regarding mobile technology acceptance in the MICE industry. In particular, this research represents an initial step in building a better understanding of consumer interactions and perceptions of mobile applications. From a practical point of view, outcomes from this study would be useful for decision-makers in preparation of strategic plans and implementation of effective tools to motivate consumers on system use and acceptance of mobile applications
Molecular pharmacology of DNA topoisomerase II drugs
Ph. D. ThesisTopoisomerase II (TOP2) is an important anti-cancer drug target. This study demonstrates that proteasomal inhibition by MG132 or PS341 potentiates the effect of TOP2 poisons on cell growth inhibition. Mitoxantrone was potentiated the most. The presence of the proteasome inhibitor MG132 prolonged the half-life of drug-induced DNA-TOP2 complexes stabilised by mitoxantrone or etoposide.
Genotoxicity was measured in K562 cells using in vitro micronucleus assays for combinations of a proteasome inhibitor (MG132 or PS341) and mitoxantrone and for each agent alone. Combinations that potentiated the cytotoxicity reduced the genotoxicity. This suggests that combining a proteasome inhibitor with a TOP2 drug has the potential to reduce late toxicities such as therapy related leukaemia.
The genotoxicity of six TOP2 poisons was determined by high throughput in vitro micronucleus assays in three Nalm-6 cell lines with differing TOP2 levels. Lower genotoxicity was observed in TOP2B knock-out and TOP2A knock-down cells, suggesting both TOP2A and TOP2B have a role in genotoxicity triggered by TOP2 poisonsBloodwis
Undocumented Asian Immigrants: Securing Higher Education and Cultural Citizenship
This research investigates how undocumented Asian immigrants navigate the obstacles of higher education. It inquires how undocumented Asian immigrant students navigated the higher education process and how institutional actors influenced their college experience, revealing the intimate interactions between undocumented students and the institutional actors. The political economy of their college application process is understood through the frameworks of liminal legality, narratives, cultural citizenship, borders and boundaries, and governmentality of migration, all of which frame the process of the data analysis.
Through the interviews of college-graduated undocumented Asian immigrants and ethnography at a local high school in the San Francisco Bay Area, this research finds that institutional actors perform a critical role in the context of their higher education process, inviting inclusionary and exclusionary spaces of belonging. Although many recent studies have illustrated the role of cultural citizenship manifest in the civic engagement of undocumented immigrants, few have seriously considered the intimate and structured terms of higher education access and process as a claim to cultural citizenship. The participants’ personal experiences with higher education is constructed in a political-social economy different from one person to another, producing versatile narratives of experiences of inclusion and exclusion in US society. By advocating for themselves, undocumented Asian students are claiming their rights to citizenship in the higher education process
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