Quantifying the Regional Load-Bearing Ability of Trans-Tibial Stumps

This paper reports findings of experiments aiming to (1) compare the load tolerant ability over different regions of stumps of lower limb amputees, (2) study the effect of walking on the load tolerant ability, and (3) examine the distal-end weight-bearing ability supported by different interface materials. The method was to apply increasing load to the stump up to the pain level through a force transducer or a digital scale, considering the effect of regional difference, walking, and interface materials. The results show that the patellar tendon and the distal end of the fibula were the best and worst load-tolerant region, respectively. Walking with prostheses tended to increase the load-tolerant ability, which is thought to be due to the massage-like effect of the socket. Different interface materials did not significantly alter the distal-end weight-bearing ability. However, there was a great difference in the distal-end weight-bearing ability among different subjects

Segmented forefoot plate in basketball footwear: Does it influence performance and foot joint kinematics and kinetics?

This study examined the effects of shoes’ segmented forefoot stiffness on athletic performance and ankle and metatarsophalangeal joint kinematics and kinetics in basketball movements. Seventeen university basketball players performed running vertical jumps and 5-msprints atmaximumeffort with 3 basketball shoes of various forefoot plate conditions (medial plate, medial + lateral plates, and no-plate control). One-way repeated measures ANOVAs were used to examine the differences in athletic performance, joint kinematics, and joint kinetics among the 3 footwear conditions (α = .05). Results indicated that participants wearing medial + lateral plates shoes demonstrated 2.9% higher jump height than those wearing control shoes (P = .02), but there was no significant differences between medial plate and control shoes (P \u3e .05). Medial plate shoes produced greater maximum plantar flexion velocity than the medial + lateral plates shoes (P \u3c .05) during sprinting. There were no significant differences in sprint time. These findings implied that inserting plates spanning both the medial and lateral aspects of the forefoot could enhance jumping, but not sprinting performances. The use of a medial plate alone, although induced greater plantar flexion velocity at the metatarsophalangeal joint during sprinting, was not effective in improving jump heights or sprint times

Comprehensive gait analysis of healthy older people: unveiling reasons for lack of long-distance walking

Many older adults do not adhere to the recommended physical activity levels. This study examines the gait changes upon long-distance walking among healthy older adults. Gait tests of 24 adults aged 65 or more were conducted at the baseline, at the end of 30 and 60 minutes of treadmill walk. Spatial temporal, kinematic and kinetic gait data were computed. Perceived level of exertion was evaluated for each subject. Ten subjects (Group B) perceived higher exertion level than the remaining fourteen subjects (Group A). After walking, group B had significant reductions in dominant-side ankle joint range of motion and power, suggesting lower-leg muscle fatigue, which appeared to be compensated by significantly increased non-dominant side knee and hip motions. These changes were not observed in Group A. Differences in gait parameters between Group A and B implied that some biomechanical factors might contribute to the lack of walking of some older adults

Comprehensive gait analysis of healthy older people: unveiling reasons for lack of long-distance walking

Many older adults do not adhere to the recommended physical activity levels. This study examines the gait changes upon long-distance walking among healthy older adults. Gait tests of 24 adults aged 65 or more were conducted at the baseline, at the end of 30 and 60 minutes of treadmill walk. Spatial temporal, kinematic and kinetic gait data were computed. Perceived level of exertion was evaluated for each subject. Ten subjects (Group B) perceived higher exertion level than the remaining fourteen subjects (Group A). After walking, group B had significant reductions in dominant-side ankle joint range of motion and power, suggesting lower-leg muscle fatigue, which appeared to be compensated by significantly increased non-dominant side knee and hip motions. These changes were not observed in Group A. Differences in gait parameters between Group A and B implied that some biomechanical factors might contribute to the lack of walking of some older adults

Stream of Search (SoS): Learning to Search in Language

Language models are rarely shown fruitful mistakes while training. They then struggle to look beyond the next token, suffering from a snowballing of errors and struggling to predict the consequence of their actions several steps ahead. In this paper, we show how language models can be taught to search by representing the process of search in language, as a flattened string -- a stream of search (SoS). We propose a unified language for search that captures an array of different symbolic search strategies. We demonstrate our approach using the simple yet difficult game of Countdown, where the goal is to combine input numbers with arithmetic operations to reach a target number. We pretrain a transformer-based language model from scratch on a dataset of streams of search generated by heuristic solvers. We find that SoS pretraining increases search accuracy by 25% over models trained to predict only the optimal search trajectory. We further finetune this model with two policy improvement methods: Advantage-Induced Policy Alignment (APA) and Self-Taught Reasoner (STaR). The finetuned SoS models solve 36% of previously unsolved problems, including problems that cannot be solved by any of the heuristic solvers. Our results indicate that language models can learn to solve problems via search, self-improve to flexibly use different search strategies, and potentially discover new ones

ANALISIS IMPLEMENTASI ERP PADA UMKM MYBEAUTYSHOP TOKO KECANTIKAN

MyBeautyShop adalah usaha yang bergerak di bidang jasa yaitu usaha yang menyediakan berbagai macam produk kecantikan baik produk lokal maupun produk luar negeri. MyBeautyShop sendiri berlokasi di Kota Batam. Saat ini, kendala yang dihadapi MyBeautyShop adalah belum adanya sistem yang mengelola, mengatur dan mengarahkan proses bisnis pemilik usaha. Sehingga penulis disini ingin membantu pemilik menganalisis sistem ERP manakah yang cocok dan sesuai dengan kebutuhan pemilik usaha dengan mengunakan metode kualitatif pendekatan deskriptif. Sistem ERP memiliki tujuan untuk mengelola kegiatan bisnis harian pemilik usaha, seperti pengelolaan keuangan, pencatatan, penyimpanan dan lain sebagainya yang mempermudah seluruh operasional pemilik usaha menjadi lebih efektif dan juga efisien. Pada laporan ini, penulis merekomendasi pemilik usaha MyBeautyShop untuk menggunakan sistem Point Of Sales (POS), dengan rekomendasikan fasilitas dari Accurate Accounting Software

Interprofessional Collaboration to Develop and Deliver Domestic Violence Curriculum to Dental Students

Domestic violence (DV) is a serious social problem that impacts significantly on communities globally. While dentists are uniquely positioned to identify patients who experience DV, there is limited content specifically addressing the issue in their undergraduate training. James Cook University (JCU) dental students revealed this gap, and, in response, an interprofessional collaboration between JCU Social Work, JCU Dentistry and the Cairns Regional Domestic Violence Service was established to codesign and deliver the Dentists and Domestic Violence—Recognise, Respond and Refer program, evaluated through Participatory Action Research (PAR) cycles. The program is informed by critical and feminist social work theory with a gendered analysis of DV. The authors present the program’s evolution and examine the four elements identified as central to its success: interprofessional collaboration, critical and feminist theory and gendered analysis, scaffolded content, and skills-based activities. This article will provide a guide for others starting work in this space. IMPLICATIONS - Designing and implementing an interprofessional domestic violence curriculum informed by critical theory and tailored for dental students’ can help meet their learning needs. - Collaboratively educating dental students to recognise and respond to domestic violence cases will enable appropriate clinical interactions with patients who are victim-survivors of domestic violence and improve the quality of referrals and interactions with community support services. - Undertaking evaluation research that guides effective domestic violence training for students across disciplines contributes to addressing domestic violence

Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR

Many members of the LuxR family of acyl-homoserine lactone (acyl-HSL)-dependent quorum-sensing transcriptional activators are thought to have the unusual characteristics of requiring the signal ligand during polypeptide synthesis to fold into an active conformation and of binding signal extraordinarily tightly. This is the case for the N-3-oxo-dodecanoyl-HSL-dependent Pseudomonas aeruginosa virulence regulator LasR. We present evidence that LasR can fold into an active conformation in vivo in the absence of the acyl-HSL ligand. We also present evidence indicating that in the cellular environment, LasR and N-3-oxo-dodecanoyl-HSL readily dissociate. After dissociation, LasR can remain in a properly folded conformation capable of reassociating with signal. We present a new model for the folding and signal binding of LasR and other members of the family of transcription factors to which LasR belongs. Our findings have important implications concerning the cellular responses to decreased environmental concentrations of signals and have implications about potential quorum-sensing inhibition strategies

Sleep in the Human Hippocampus: A Stereo-EEG Study

Background. There is compelling evidence indicating that sleep plays a crucial role in the consolidation of new declarative, hippocampus-dependent memories. Given the increasing interest in the spatiotemporal relationships between cortical and hippocampal activity during sleep, this study aimed to shed more light on the basic features of human sleep in the hippocampus. Methodology/Principal Findings. We recorded intracerebral stereo-EEG directly from the hippocampus and neocortical sites in five epileptic patients undergoing presurgical evaluations. The time course of classical EEG frequency bands during the first three NREM-REM sleep cycles of the night was evaluated. We found that delta power shows, also in the hippocampus, the progressive decrease across sleep cycles, indicating that a form of homeostatic regulation of delta activity is present also in this subcortical structure. Hippocampal sleep was also characterized by: i) a lower relative power in the slow oscillation range during NREM sleep compared to the scalp EEG; ii) a flattening of the time course of the very low frequencies (up to 1 Hz) across sleep cycles, with relatively high levels of power even during REM sleep; iii) a decrease of power in the beta band during REM sleep, at odds with the typical increase of power in the cortical recordings. Conclusions/Significance. Our data imply that cortical slow oscillation is attenuated in the hippocampal structures during NREM sleep. The most peculiar feature of hippocampal sleep is the increased synchronization of the EEG rhythms during REM periods. This state of resonanc