Vaccine delivery with microneedle skin patches in nonhuman primates

Transcutaneous drug delivery from planar skin patches is effective for small-molecule drugs and skin-permeable vaccine adjuvants. However, to achieve efficient delivery of vaccines and other macromolecular therapeutics into the skin, penetration of the stratum corneum is needed. Topically applied skin patches with micron-scale projections ('microneedles') pierce the upper layers of the skin and enable vaccines that are coated on or encapsulated within the microneedles to be dispersed into the skin. Although millimeter-scale syringes have shown promise for vaccine delivery in humans and technologies, such as the Dermaroller (Dermaroller, Wolfenbüttel, Germany), exist for creating microscale punctures in the skin for delivery of solutions of therapeutics, solid microprojection microneedles coated with dry vaccine formulations offer a number of valuable features for vaccination, including reduced risk of blood-borne pathogen transmission or needle-stick injury, the potential for vaccine administration by minimally trained personnel or even self administration and the use of solid-state vaccine formulations that may reduce or eliminate cold-chain requirements in vaccine distribution. Recent studies in mice have demonstrated the ability of microneedles to effectively deliver vaccines to the skin, eliciting protective immunity to influenza, hepatitis C and West Nile virus.Ragon Institute of MGH, MIT and HarvardMassachusetts Institute of TechnologyHarvard UniversityNational Institutes of Health (U.S.) (AI095109)National Institutes of Health (U.S.) (AI096040)National Institutes of Health (U.S.) (AI095985)National Institutes of Health (U.S.) (AI078526)National Institutes of Health (U.S.) (AI060354)United States. Dept. of Defense (Contract W911NF-07-D-0004

Coupled heat transfer to workpiece, wheel and fluid in grinding, and the occurrence of workpiece burn

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Simultaneously developing laminar convection in rotating isothermal square channels

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A Dimensionless Model for Transient Turbulent Natural Convection in Isochoric Vertical Thermal Energy Storage Tubes

In this study, turbulent natural convection heat transfer during the charge cycle of an isochoric vertically oriented thermal energy storage (TES) tube is studied computationally and analytically. The storage fluids considered in this study (supercritical CO2 and liquid toluene) cover a wide range of Rayleigh numbers. The volume of the storage tube is constant and the thermal storage happens in an isochoric process. A computational model was utilized to study turbulent natural convection during the charge cycle. The computational results were further utilized to develop a conceptual and dimensionless model that views the thermal storage process as a hot boundary layer that rises along the tube wall and falls in the center to replace the cold fluid in the core. The dimensionless model predicts that the dimensionless mean temperature of the storage fluid and average Nusselt number of natural convection are functions of L/D ratio, Rayleigh number, and Fourier number that are combined to form a buoyancy-Fourier number

Principles of heat and mass transfer

Completely updated, the seventh edition provides engineers with an in-depth look at the key concepts in the field. It incorporates new discussions on emerging areas of heat transfer, discussing technologies that are related to nanotechnology, biomedical engineering and alternative energy. The example problems are also updated to better show how to apply the material. And as engineers follow the rigorous and systematic problem-solving methodology, they'll gain an appreciation for the richness and beauty of the discipline