12 research outputs found
In vitro effects of diacetoxyscirpenol (DAS) on human and rat granulo-monocytic progenitors.
No full textInternational audienceDiacetoxyscirpenol (DAS) is a trichothecene mycotoxin produced by various species of fungi. Trichothecenes are known as major contaminants of cereals and cereal-containing foods. DAS has been detected in agricultural products worldwide and persists in products after processing. In human as well as in animals, DAS consumption has been shown to induce haematological disorders (neutropenia, aplastic anemia). Granulo-monocytic progenitors (CFU-GM) from human umbilical cord blood and rat bone marrow have been cultured in the presence of DAS (from 10(-8) M to 5 x 10(-10) M) for 14 days. Study of concentration and effect relationships have shown a sharp effect of DAS on rat CFU-GM between 10(-7) M and 10(-8) M, while human CFU-GM are able to grow in the presence of 10(-8) M of the toxin. IC50 values on day 14 are respectively, 7.6 x 10(-9) M for human CFU-GM and 6.2 x 10(-9) M for rat CFU-GM
Effect of enzyme treatment with β-glucosidase on antioxidant capacity of mulberry (Morus alba L.) leaf extract
No full textFerulic acid released by treatment with Aspergillus oryzae contributes to the cellular antioxidant capacity of wheat germ extract
No full text
Antioxidative and antigenotoxic effects of onion peel extracts in non-cellular and cellular systems
No full textUnraveling the in vitro and in vivo metabolism of diacetoxyscirpenol in various animal species and human using ultrahigh-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry
No full textInduction of Alcohol-Metabolizing Enzymes and Heat Shock Protein Expression by Ethanol and Modulation by Fenugreek Seed Polyphenols in Chang Liver Cells
No full text
