Regions exhibiting significantly increased ‘self – queen’ activity for the depressed group compared to the control group^†.

<p>Regions exhibiting significantly increased ‘self – queen’ activity for the depressed group compared to the control group^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078844#nt105" target="_blank">†</a>}.</p

fMRI stimulus presentation.

<p>a =  self condition, neutral stimulus word; b = other condition, positive stimulus word; c = case condition, negative stimulus word; d = Rest Interval.</p

Sagittal, axial and coronal views of areas of statistically significant BOLD activation (p = 0.005 uncorrected, cluster threshold 8 voxels) for the condition ‘self – queen’ in (a) the depressed group (n = 13) and (b) the control group (n = 14).

<p>Areas in red represent regions of increased BOLD activity in the ‘self’ as opposed to ‘queen’ condition.</p

Regions exhibiting significant ‘self – queen’ activity in the depressed group^†.

<p>Regions exhibiting significant ‘self – queen’ activity in the depressed group^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078844#nt101" target="_blank">†</a>}.</p

Percentage of responses answered ‘yes’.

<p>Percentage of responses answered ‘yes’.</p

Regions exhibiting significant ‘self – queen’ activity in the control group^†.

<p>Regions exhibiting significant ‘self – queen’ activity in the control group^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0078844#nt103" target="_blank">†</a>}.</p

Response times (ms).

<p>Response times (ms).</p

Sagittal (a), axial (b) and coronal (c) views of areas with statistically significant BOLD activation (p = 0.005 uncorrected, cluster threshold 8 voxels) for the comparison of the ‘self – queen’ contrast between the depressed and control groups.

<p>(d) represents the statistical distribution of the BOLD signal change in the highlighted area. The areas in red represent areas where the depressed participants showed significantly greater BOLD signal change for the contrast ‘self – queen’ than the control group.</p

Coordinates of local maxima for brain regions showing increased (cued > uncued) and decreased (uncued > cued) functional connectivity (PPI) after TMR (<i>n</i> = 20).

<p>Coordinates of local maxima for brain regions showing increased (cued > uncued) and decreased (uncued > cued) functional connectivity (PPI) after TMR (<i>n</i> = 20).</p

Performance improvement at retest.

<p><b>(a)</b> Comparison of presleep sequence performance to early blocks of sequence retest showed a significant cueing effect. <b>(b)</b> Accuracy improvement was also significantly greater for the cued sequence at early blocks. <b>(c)</b> Performance improvement for both sequences was comparable at late sequence blocks and random blocks that followed. Error bars represent standard error of the mean (SEM) (<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002451#pbio.1002451.s001" target="_blank">S1 Data</a>).</p