Additional file 1: Figure S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Additional neuropathology. Additional photomicrographs from three family members. Individuals, immunohistochemistry, and enlargement as indicated. (TIF 11179 kb

Additional file 3: Table S2. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Individual data from previous publications (systematic review). Numbers indicate disease duration at first reported or observed symptom. Data in parentheses are successive or vaguely specified development or data unspecifically described. *Symptoms reported by patient or relative. #Unreliable data owing to possible pharmacological cause (neuroleptics). §Data too imprecisely reported to be included in calculations. AD Alzheimer’s disease, MCI Mild cognitive impairment, Dementia NOS Dementia not otherwise specified, CSF Cerebrospinal fluid, Aβ 42 Amyloid-β 1–42, APOE Apolipoprotein E, ADL Activities of daily living. (PDF 161 kb

Additional file 4: Table S3. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Cerebrospinal fluid examinations. Numbers in parentheses indicate disease duration when cerebrospinal fluid was retrieved. Upward filled triangles = value above laboratory’s reference value for healthy individuals; downward filled triangles = value below laboratory’s reference value for healthy individuals. aCompared with healthy control subjects (157 ± 65 pg/ml, n = 24) and patients with AD (555 ± 248 pg/ml, n = 31). bCompared with healthy control subjects (29 ± 10 pg/ml, n = 21) and patients with AD (86 ± 39 pg/ml, n = 31). N/A Not assessed. (PDF 304 kb

Additional file 2: Table S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

MAPT haplotype determination based on exome sequencing data. Individuals, residues, and haplotype as indicated. Note that the proband, individual III-2, had Alzheimer’s disease and was excluded from the study. (PDF 181 kb

Additional file 1: Figure S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Additional neuropathology. Additional photomicrographs from three family members. Individuals, immunohistochemistry, and enlargement as indicated. (TIF 11179 kb