Cardiac stem cells: A promising treatment option for heart failure.

Cardiovascular diseases are the most common cause of death in the world. The development of heart failure is mainly due to the loss of cardiomyocytes following myocardial infarction and the absence of endogenous myocardial repair. Numerous studies have focused on cardiac stem cells (CSCs) due to their therapeutic benefit, particularly in the treatment of heart failure. It has previously been demonstrated that CSCs are able to promote the regeneration of cardiomyocytes in animals following myocardial infarction. However, the underlying mechanism(s) remain unclear. This review mainly discusses the cardioprotective effect of CSCs and the effect of CSCs on the function of cardiomyocytes, and compares the efficacies of CSCs from rats, mice and humans, thereby contributing to an improved understanding of CSCs as a promising treatment option for heart failure

Leveraging Node Attributes for Incomplete Relational Data

Relational data are usually highly incomplete in practice, which inspires us to leverage side information to improve the performance of community detection and link prediction. This paper presents a Bayesian probabilistic approach that incorporates various kinds of node attributes encoded in binary form in relational models with Poisson likelihood. Our method works flexibly with both directed and undirected relational networks. The inference can be done by efficient Gibbs sampling which leverages sparsity of both networks and node attributes. Extensive experiments show that our models achieve the state-of-the-art link prediction results, especially with highly incomplete relational data.Comment: Appearing in ICML 201

MetaLDA: a Topic Model that Efficiently Incorporates Meta information

Besides the text content, documents and their associated words usually come with rich sets of meta informa- tion, such as categories of documents and semantic/syntactic features of words, like those encoded in word embeddings. Incorporating such meta information directly into the generative process of topic models can improve modelling accuracy and topic quality, especially in the case where the word-occurrence information in the training data is insufficient. In this paper, we present a topic model, called MetaLDA, which is able to leverage either document or word meta information, or both of them jointly. With two data argumentation techniques, we can derive an efficient Gibbs sampling algorithm, which benefits from the fully local conjugacy of the model. Moreover, the algorithm is favoured by the sparsity of the meta information. Extensive experiments on several real world datasets demonstrate that our model achieves comparable or improved performance in terms of both perplexity and topic quality, particularly in handling sparse texts. In addition, compared with other models using meta information, our model runs significantly faster.Comment: To appear in ICDM 201

Dirichlet belief networks for topic structure learning

Recently, considerable research effort has been devoted to developing deep architectures for topic models to learn topic structures. Although several deep models have been proposed to learn better topic proportions of documents, how to leverage the benefits of deep structures for learning word distributions of topics has not yet been rigorously studied. Here we propose a new multi-layer generative process on word distributions of topics, where each layer consists of a set of topics and each topic is drawn from a mixture of the topics of the layer above. As the topics in all layers can be directly interpreted by words, the proposed model is able to discover interpretable topic hierarchies. As a self-contained module, our model can be flexibly adapted to different kinds of topic models to improve their modelling accuracy and interpretability. Extensive experiments on text corpora demonstrate the advantages of the proposed model.Comment: accepted in NIPS 201