6 research outputs found
Nanoelectronic Coating Enabled Versatile Multifunctional Neural Probes
Brain function can
be best studied by simultaneous measurements
and modulation of the multifaceted signaling at the cellular scale.
Extensive efforts have been made to develop multifunctional neural
probes, typically involving highly specialized fabrication processes.
Here, we report a novel multifunctional neural probe platform realized
by applying ultrathin nanoelectronic coating (NEC) on the surfaces
of conventional microscale devices such as optical fibers and micropipettes.
We fabricated the NECs by planar photolithography techniques using
a substrate-less and multilayer design, which host arrays of individually
addressed electrodes with an overall thickness below 1 μm. Guided
by an analytic model and taking advantage of the surface tension,
we precisely aligned and coated the NEC devices on the surfaces of
these conventional microprobes and enabled electrical recording capabilities
on par with the state-of-the-art neural electrodes. We further demonstrated
optogenetic stimulation and controlled drug infusion with simultaneous,
spatially resolved neural recording in a rodent model. This study
provides a low-cost, versatile approach to construct multifunctional
neural probes that can be applied to both fundamental and translational
neuroscience
Histological study of tissue reaction to the microfluidic meshwork in comparison with AGV 3 months post implantation.
<p><b>A.</b> capsule beneath the plate of AGV; <b>B.</b> minimal reaction to the meshwork in rabbit 1, inset figure is a magnified view to a single channel of the meshwork (400x); <b>C.</b> minimal reaction to the meshwork in rabbit 2; <b>D.</b> minimal reaction to the meshwork in rabbit 3. Arrows in B, C and D is to delineate the meshwork.</p
Proposed concept of a new GDI.
<p>Plate of the GDI is replaced by the microfluidic meshwork.</p
Images of the microfluidic meshwork.
<p>A. on a substrate. B. Zoom-in view of the mesh grids. Arrows denote the fluid outlets. Scale bars: 500 μm and 100 μm.</p
Gross section of tissue reactions to the microfluidic meshwork in comparison with AGV 3 months post implantation.
<p><b>A.</b> AGV <b>B.</b> microfluidic meshwork. Inset figures are magnified views of the microfluidic meshwork.</p
Additional file 1: Table S1. of Low grade astrocytoma transformating primitive neuroectodermal tumour in an adult? A case report and review of literature
Summary of clinical and histological features of cases in the past decade. (DOC 151 kb