Pathology of malignant breast tumors

Merfološka opredelitev tumorjev dojke po načelih moderne kirurške patologije tumorja daje kliniku poleg osnovnih podatkov o naravi tumorja tudi pomembne prognostične informacije. Pri karcinomu dojke so med njimi na vrhu pomembnosti: stanje aksilarnih bezgavk (pozitivne ali negativne bezgavke), stopnja malignosti tumorja, velikost tumorja, verjetno tudi histološki tip. Z razvojem modernih tehnologij lahko tako patolog kot klinik uporabljata še mnoge nove metode, s katerimi opredeljujeta tumor tudi biokemično in molekularno. Zaenkrat pa vse te nove opredelitve še ne dosegajo prognostične veljave klasičnih morfoloških lastnosti. Prav zato pa mora patolog skrbno upoštevati priporočila in pravila o obdelavi kirurškega vzorca, da lahko opredeli vrsto morfoloških lastnosti, ki vsebujejo največ napovedno veljavnih podatkov. V članku govorim o osnovnih morfoloških metodah, o posameznih pomembnejših tumorjih dojke ter o nekaterih novih biokemičnih in molekularnih metodah v diagnostiki raka dojke.The morphological classification of breast tumors, in accordance to principlesof modern surgical pathology, provides the clinician not only with the basic data on the nature of tumor but also with important prognostic information. In the carcinoma of the breast, such information are as follows: lymph node status (positive or negative lymph nodes), grade of malignancy, size of the tumor and probably its histological type. The development of new technologies enabled the pathologist as well as the clinician to use numerous new tools and methods to determine a number of biochemical and molecular characteristics of the tumor. At this moment, however, the latter do not achieve the prognostic relevance of classical morphological features. Therefore, the pathologist should carefully folow the recommendatios and guidelines for handling and reporting surgical specimens since only by such means all morphological features giving most important prognostic information will be identified. In the article, some basic morphological methods, several important breast tumors, and a few biochemical and molecular methods in the diagnostics of breast cancer are discussed

Acinic cell carcinoma of the breast: A comprehensive review

Acinic cell carcinoma of the breast is a rare special subtype of breast cancer in the category of salivary gland-type tumors. It is morphologically similar to acinic cell carcinomas of salivary glands and pancreas and has a triple-negative phenotype (estrogen receptor-negative, progesterone receptor-negative, and Her-2/neu negative). Its molecular genomic features are more similar to triple-negative breast cancer of no special type than to its salivary gland counterpart. However, the clinical course of the mammary acinic cell carcinoma appears to be less aggressive than the usual triple-negative breast carcinomas. This review comprehensively summarizes the current literature on the clinicopathologic, immunohistochemical, and molecular features of this rare and distinct subtype of breast cancer