Additional file 5: Table S5. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Factors associated with overall survival (OS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 38 kb

Additional file 6: Table S6. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Factors associated with specific survival (SS) in 103 Triple-negative canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. When several significant prognostic factors overlapped, only one was selected for the multivariate analysis (LVI was chosen between lymph node status and LVI because it could have been determined in all cases). (DOC 35 kb

Additional file 1: Table S1. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Primary antibodies and immunohistochemical protocols (Benchmark XT Ventana, Roche Diagnostics). All dilutions were performed using a commercially available diluent (Ventana Medical Systems). aUltraview and bOptiview Universal DAB detection kit: multimer-technology based detection system. cIView Universal DAB detection kit: biotin streptavidin system. ERα: Estrogen Receptor alpha, PR: Progesterone Receptor, HER2: Epidermal Growth Factor type 2 Receptor, CK5/6: Cytokeratin 5/6, EGFR: Epidermal Growth Factor type 1 Receptor, IGF1R: Insulin-like growth factor type 1 receptor. CC1: Cell Conditioning 1. (DOC 33 kb

Additional file 4: Table S4. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Factors associated with specific survival (SS) in 47 Luminal canine invasive mammary carcinomas. Univariate (log rank test) and multivariate survival analyses (Cox proportional hazard regression). HR: Hazard Ratio, 95 % CI: 95 % Confidence Interval, HER2: Epidermal Growth Factor type 2 Receptor, IGF1R: Insulin-like Growth Factor type 1 Receptor, LVI: Lymphovascular Invasion. (DOC 33 kb

Additional file 2: Table S2. of The dog as a naturally-occurring model for insulin-like growth factor type 1 receptor-overexpressing breast cancer: an observational cohort study

Significant associations between IGF1R expression and clinicopathological features of 47 luminal canine mammary carcinomas. IGF1R score 0–1+ is considered as the reference for each parameter. IGF1R Insulin-like Growth Factor type 1 Receptor. LVI: Lymphovascular Invasion. OR: Odd Ratio. 95 % CI: 95 % Confidence Interval. (DOC 30 kb