The Reactions of the Methylidyne Radical with Nitriles in Cold Molecular Clouds and Planetary Atmospheres

В данной работе в рамках теории функционала плотности с использованием гибридного функционала ωb97xd и базисного набора cc-pvtz рассчитаны молекулярные параметры реагентов, переходных состояний, барьеров и продуктов химических реакций синильной кислоты, ацетонитрила, пропаннитрила с метиновым радикалом. Построены профили поверхностей потенциальной энергии реакций. Энергии структур рассчитаны в пределе бесконечного базиса при помощи двухточечной экстраполяционной формулы, значения для которой были получены методом связанных кластеров в реализации CCSD(T)-F12. Рассчитаны константы скорости для каждого шага реакций на основе теории РРКМ.In this work, using the hybrid density functional theory method ωb97xd/cc-pvtz, the molecular parameters of reagents, transition states, barriers, and products of chemical reactions of hydrocyanic acid, acetonitrile, and propanenitrile with a methine radical are calculated. Potential energy surfaces of reactions are constructed. The rate constants for each reaction step were calculated using the RRKM approach.Работа выполнена в рамках гранта № 075-15-2021-597 «Происхождение и эволюция органических молекул в нашей Галактике»

Cancer of the cervix uteri: magnetic resonance and clinical factors of prognosis

Based on their observations, the authors have made univariate and multivariate analyses of the prognostic importance of a number of magnetic resonance and clinical factors in cancer of the cervix uteri

Role of magnetic resonance imaging in the diagnosis of recurrent cancer of the cervix uteri

Objective: to define a role of magnetic resonance imaging (MRI) in the follow-up of patients with cancer of the cervix uteri (CCU), who have undergone radiation therapy and chemoradiation therapy and to describe the types of the MRI pattern of recurrent CCU in the pelvic region.Materials and methods. The results of a follow-up of 82 patients with a 4-47- (median 12 months) month history of invasive CCU were analyzed.Results. Out of the 82 patients with invasive CCU, 25 were found to have pelvic recurrences; in 23 cases MRI revealed the latter (in the cervix uteri (n = 6), corpus uteri (n = 2), vagina (n = 2), parametrium (n = 2), iliac (n = 10), paraaortic (n = 5) lymph nodes, and pelvic wall (n=5).Conclusion. The findings suggest that pelvic MRI is an effective technique to detect and estimate the extent of a pelvic recurrence and it is expedient to incorporate it into the scope of a follow-up after radiation therapy and chemoradiation therapy in patients with invasive CCU

The experience of organizing an individual bank of breast milk at the perinatal center

Organizing an individual bank of breast milk helps to preserve an alternative possibility to continue breast-feeding of a newborn baby with pumped and (or) frozen mother’s milk. Pumped milk (milk defrosted not later than 3–6 months) is microbiologically safe food for a baby. Frozen pumped milk is much better than mixtures for babies. Sanitary Regulations and Standards 2.1.3.2630.-10 clause 3.5 are to be updated to reflect the technology of breast-feeding preservation forsick babies who do not have breast-feeding since the first days of life

Borderline papillary serous tumor of the ovary: the authors’ observation and a concise review of literature

The paper presents a case of borderline papillary serous cystadenoma in a 34-year-old female patient, by describing the magnetic resonance image of borderline ovarian tumors in detail and reviewing the data available in the literature on the specific features of their imaging and diagnosis

INFLUENCE OF APOE GENOTYPES ON BIOCHEMICAL INDICES OF IRON AND LIPID METABOLISM IN PATIENTS WITH THE ENDOMETRIUM NEOPLASTIC DISEASES AND HEAL THY WOMEN

Objective. APOE genotype association with the level of iron in plasma and the risk of endometrial neoplastic diseases has not been studied. The aim of the work was to analyze the genotypic associations of the apolipoprotein E (APOE) with iron and lipid levels in endometrial hyperplasia (EH)/endometrial cancer (EC) patients and healthy women.Materials and methods. The biochemical blood levels of iron and cholesterol metabolism detected in women d with diagnosed endometrial hyperplasia (53), endometrial cancer (87) and healthy women (70) are determined on an automated analyzer «OLYMPUS AU – 400”. The genotyping was performed with a PCR-RFLP (polymerase chain reaction with restriction fragment length polymorphism) technique.Results. A statistically significant decrease in the levels of serum iron, transferrin saturation, high-density lipoprotein on the one hand, and a statistically significant increase in body mass index, triglycerides, very low density lipoproteins, atherogenic index in patients with endometrial adenocarcinoma was observed. Statistically significant differences in the distribution of E3, E4, E2 allele frequencies between patients and healthy women (P = 0.048) was revealed. E3 allele frequency was reduced, and the E2 allelewas increased in patients with EC. It was shown that the serum iron level was significantly increased in EC patients and healthy carriers of the genotype E3/E2 (P= 0,0014 and 0,0363 respectively). There was significantly elevated triglyceride level in carriers of the minor genotypes E2/E4, E4/E4 among patients with EH (0,0389).Conclusions. Genotype E3/E2 compared with other APOE genotypes under study is associated with elevated levels of iron and the risk of endometrial cancer. The association APOE 2/2, 2/4, 4/4 as well as 3/2 with endometrial neoplastic diseases requires further investigation. The data obtained can be the basis for the creation of a marker system for determining a high level susceptibility to malignant disease of the female reproductive system

Ionization dynamics of XUV excited clusters: the role of inelastic electron collisions

We report on the ionization and nanoplasma dynamics of small xenon clusters irradiated by intense, short pulses of a short-wavelength free-electron laser. Fluorescence spectroscopy indicates that inelastic electron collisions play a prominent role in the formation of the highest charge states. From the spectral distribution an electron temperature of 27 eV is deduced which corresponds to the average excess energy of the Auger- and photoelectrons ionized from individual atoms but trapped in the cluster core. This suggests that fluorescence spectra reflect a very early stage within the nanoplasma dynamics and shows how a part of the kinetic energy of the plasma electrons trapped in the cluster potential is transferred to the ions.ISSN:1361-6455ISSN:0368-3508ISSN:0953-4075ISSN:0022-370