Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

Synthesis and Spectroscopic Investigation of Binding of Novel Thiazolo [2, 3-a] isoquinoline analog with Bovine Serum Albumin

A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid was carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The interaction of CBIQTGA with Bovine Serum Albumin (BSA) was studied using UV spectroscopy, spectrofluorimetry and circular dichroism (CD) techniques

Synthesis and spectroscopic investigation of binding of novel Thiazolo [2, 3-a] isoquinoline analog with bovine serum albumin

1081-1085A condensation reaction between 1-cyclobutyl-3,4-dihydroisoquinoline and thioglycolic acid has been carried out using DCC yields 10b-cyclobutyl-5,6-dihydro-2H-thiazolo [2, 3-a] isoquinolin-3(10bH)-one [CBIQTGA]. The synthesized compound is characterised by using spectroscopic techniques. The interaction of CBIQTGA with bovine serum albumin has been studied using UV spectroscopy, spectrofluorimetry and circular dichroism techniques

Blind docking of 4-Amino-7-Chloroquinoline analogs as potential dengue virus protease inhibitor using CB Dock a web server

55-57Currently, there is no approved drug to combat dengue. Various quinoline derivatives are known for potential antimalarial, antiviral activities, etc. In the present work docking between 4-Amino-7-Chloroquinoline analogs was performed with dengue virus NS2B/NS3 protease using CB dock, a web server. Lys74, Ile165, Val147, Asn152, Asn167, Trp83 and Leu149 amino acid residues were found to be in contact with designed 4-Amino-7-Chloroquinoline analogs. Different modes of binding like hydrogen bonding, hydrophobic interactions, etc with designed compounds improve potential anti-dengue characteristics in silico. ADME results are in acceptable range

Synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido) benzoate] (ChTfAB) a thermotropic liquid crystalline material

755-760The synthesis of cholest-5-en-3-ol(3β)-3-[4-(2,2,2-trifluoroacetamido)benzoate] (ChTfAB) is carried out by esterification of cholesterol and p-nitrobenzoic acid using DCC, DMAP, followed by reduction of nitro group using SnCl2. The so formed amino group is further N-acylated using trifluoroacetic anhydride. The newly synthesized compound is characterized using IR and 1H NMR spectroscopic techniques. Its mesomorphic properties have been investigated using Differential Scanning Colorimetry (DSC) and Polarising Optical Microscopy (POM). The thermal and phase behaviour studies reveal the synthesized compound to be an enantiotropic, thermotropic liquid crystal. This synthesized compound overcomes the problem of degrading at the melting temperature associated with one of the previously synthesized and reported steroidal compound