Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme

Five novel tigliane-type diterpenes, stelleracins A–E (3–7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3–5 showed potent anti-HIV activity (EC90 0.00056–0.0068 μM) and relatively low or no cytotoxicity (IC50 4.4–17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates

Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from <i>Stellera chamaejasme</i>

Five novel tigliane-type diterpenes, stelleracins A–E (<b>3</b>–<b>7</b>), a novel flavanone dimer, chamaeflavone A (<b>8</b>), and six known compounds were isolated from the roots of <i>Stellera chamaejasme</i>. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds <b>3</b>–<b>5</b> showed potent anti-HIV activity (EC₉₀ 0.00056–0.0068 μM) and relatively low or no cytotoxicity (IC₅₀ 4.4–17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates

Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from <i>Stellera chamaejasme</i>

Five novel tigliane-type diterpenes, stelleracins A–E (<b>3</b>–<b>7</b>), a novel flavanone dimer, chamaeflavone A (<b>8</b>), and six known compounds were isolated from the roots of <i>Stellera chamaejasme</i>. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds <b>3</b>–<b>5</b> showed potent anti-HIV activity (EC₉₀ 0.00056–0.0068 μM) and relatively low or no cytotoxicity (IC₅₀ 4.4–17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates

Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme

Five novel tigliane-type diterpenes, stelleracins A–E (3–7), a novel flavanone dimer, chamaeflavone A (8), and six known compounds were isolated from roots of Stellera chamaejasme. Their structures were elucidated by extensive spectroscopic analyses. The isolated compounds were evaluated for anti-HIV activity in MT4 cells. New compounds 3–5 showed potent anti-HIV activity (EC(90) 0.00056–0.0068 μM) and relatively low or no cytotoxicity (IC(50) 4.4–17.2 μM). These new compounds represent promising new leads for development into anti-AIDS clinical trial candidates