Incidence of Odontogenic Keratocysts in Patients with Gorlin-Goltz Syndrome according to Age, Gender and Location

Svrha ovoga rada bila je prikazati nastanak odontogenih keratocista (OKC) i keratocistama sličnih lezija u oboljelih od Gorlin-Goltzova sindroma s obzirom na dob i spol bolesnika te na mjesto nastanka OKC-a (donja čeljust, gornja čeljust, meka tkiva i maksilarni sinusi). Od godine 1965. do 1998. u 30 je bolesnika s Gorlin-Goltzovim sindromom ustanovljeno 58 OKC-a koji su potvrđeni i histopatološkom dijagnozom. Bolesnici su bili u dobi od 10 do 90 godina, prosječne dobi 33,71. Prosječna dob muških bolesnika bila je 35,53 godina života, a ženskih 31,12 godina života. OKC je u sklopu Gorlin-Goltzova sindroma češće dijagnosticiran u muškaraca (58,62%) nego u (41,38%). Najčešća dob u kojoj je OKC nađen u bolesnika s Gorlin-Goltzovim sindromom bila je između 21. i 30. godine. S obzirom na lokalizaciju, većina OKC-a nalazila se u donjoj čeljusti (60,34%), zatim u gornjoj čeljusti (15,52%), u mekim tkvima (13,79%) te u maksilarnim sinusima (10,34%).The aim of this study was to determine the appearance of odontogenic keratocysts (OKC) and keratocyst-like lesions ( KLL) in patients with Gorlin-Goltz syndrome, according to age and gender of participants, and in relation to the place of origin (mandible, maxilla, soft tissues, which include the mucosa of the alveolar ridge, skin of the nose and face, parotid gland together with maxillary sinuses). From 1965 until 1998, 58 OKC were found in 30 patients with Gorlin Goltz syndrome and confirmed by histopathologic analysis. Patients were aged from 10 to 90 years. Average age of the patients with Gorlin-Goltz syndrome was 33.71 years. Average age in males was 35.53 years and in females 31.12 years. OKC connected with Gorlin Goltz syndrome were more frequently found in males (58.62%) compared to the females (41.38%). The peak incidence of OKC in patients with Gorlin-Goltz syndrome was between ages 21-30 years. According to the location, OKC were found predominantly in the mandible (60.34%), the maxilla (15.52%), soft tissues (13.79%), and in maxillary sinuses (10.34%)

The significance of oral and systemic factors in the Australian and Croatian patients with oral lichen planus.

Oral lichen planus (OLP) is an immunologically T cell-mediated disease caused by an unknown stimulus. Despite intensive investigation its pathogenesis still remains unknown. A few possible associations between OLP and certain diseases such as thyroid and malignant diseases as well as specific medication intake have been proposed in the literature with inconsistent findings.We aimed to investigate the profile of 163 Australian and 163 Croatian OLP patients with special regard to their systemic diseases, medication intake (with special regard to the drugs that metabolize through Cytochrome P450), OLP type and localization, as well as involvement of other body surfaces with lichen. We did not find any statistical significance with regard to the OLP presence and thyroid and malignant diseases. As expected, the reticular type of OLP was most prevalent, as well as involvement of the both buccal mucosas. There was no significant association with other oral diseases such as labial herpes. Simultaneous involvement of other body surfaces in patients with OLP does not seem to be prevalent. None of the medical conditions which were investigated had significant correlation with OLP neither in Australian nor in Croatian patients with OLP. Furthermore, the use of drugs which metabolize through Cytochrome P450 (CYP450) was not significantly correlated with OLP in either studied population. Therefore, we conclude that patients with OLP are not to be routinely screened for any systemic conditions.</p

Utjecaj psihološkog stanja na oralni lihen planus

Oral lichen planus (OLP) is a T-cell mediated disease directed to a still unknown antigen, which may affect oral mucosa. The aim of this study was to determine whether differences in anxiety, depression and stress could be seen in patients with OLP in acute stage and in remission, as well as in comparison with healthy control subjects. The study included 50 OLP patients aged 22-79 (mean age 61.04) years and 50 control subjects who had healthy oral mucosa aged 38-80 (mean age 58.70) years. Patients with OLP filled out the State-Trait Anxiety Inventory for Adults and Beck Depression Inventory II test in acute stage and in remission. Control subjects also filled out the same tests. On detailed medical history, study subjects were asked about the possible stressors, which might have happened in the previous year. Statistical analysis was performed by use of descriptive statistics and t-test. There were no differences in the level of anxiety, depression and stress between the two stages of OLP disease (acute vs. remission period). Patients with OLP were significantly more anxious, depressed and stressed in both OLP stages as compared with healthy controls. It might be that psychological disturbances precede OLP development rather than worsening the disease process itself.Oralni lihen planus (OLP) je bolest posredovana T-limfocitima na još uvijek nepoznati antigen, koja može zahvatiti oralne sluznice. Cilj ovoga istraživanja bio je ustanoviti postoje li razlike u anksioznosti, depresiji i stresu između bolesnika s akutnim OLP-om u odnosu na fazu remisije OLP-a i u usporedbi s kontrolnom skupinom. U ispitivanje je bilo uključeno 50 bolesnika s OLP-om (starosti 22-79 godine, prosječne dobi 61,04 godine) i 50 kontrolnih ispitanika (starosti 38-80 godina, prosječne dobi 58,70 godina). Svaki pacijent s OLP-om je ispunio STAI i Beck Depression Inventory II. test za vrijeme akutne faze i za vrijeme remisije. Za vrijeme uzimanja anamneze je svaki ispitanik upitan o mogućim stresnim događajima koji su se dogodili unatrag godine dana. Statistička analiza je napravljena uz upotrebu deskriptivne statistike i t-testa. Nije bilo razlika u razini anksioznosti, depresije i stresa u bolesnika s OLP-om između dvije faze bolesti (akutna faza u odnosu na remisiju). Bolesnici s OLP-om su bili značajno više anksiozni, deprimirani i u stresu u obje faze bolesti u odnosu na zdrave kontrolne osobe. Moguće je da psihološki poremećaji prethode nastanku OLP-a prije nego što pogoršavaju tijek OLP-a

The significance of oral and systemic factors in Australian and Croatian patients with oral lichen planus

Oral lichen planus (OLP) is an immunologically T cell-mediated disease caused by an unknown stimulus. Despite intensive investigation its pathogenesis still remains unknown. A few possible associations between OLP and certain diseases such as thyroid and malignant diseases as well as specific medication intake have been proposed in the literature with inconsistent findings. We aimed to investigate the profile of 163 Australian and 163 Croatian OLP patients with special regard to their systemic diseases, medication intake (with special regard to the drugs that metabolize through Cytochrome P450), OLP type and localization, as well as involvement of other body surfaces with lichen. We did not find any statistical significance with regard to the OLP presence and thyroid and malignant diseases. As expected, the reticular type of OLP was most prevalent, as well as involvement of the both buccal mucosas. There was no significant association with other oral diseases such as labial herpes. Simultaneous involvement of other body surfaces in patients with OLP does not seem to be prevalent. None of the medical conditions which were investigated had significant correlation with OLP neither in Australian nor in Croatian patients with OLP. Furthermore, the use of drugs which metabolize through Cytochrome P450 (CYP450) was not significantly correlated with OLP in either studied population. Therefore, we conclude that patients with OLP are not to be routinely screened for any systemic conditions