Feed Supplements for Young Dairy Breed Calves After Turn-Out to Pasture: Effect on Weight Gain and Subclinical Coccidiosis in Organic Production Systems

On two organic farms, the effect of supplementation with either home-grown barley or organic commercial concentrates primarily based on local protein sources and barley, on weight gain and subclinical coccidiosis was investigated in 3-5 months old dairy breed calves in the period after turn-out to ryegrass/clover pastures. The calves (mean liveweight ± SD, 124 ± 24 kg and 133 ± 24 kg on Farm I and II respectively) were supplemented daily with 3 kg energy and protein-rich commercial concentrates (group EP), 3 kg barley (group E) or ½ kg barley (group Eres) for 8 weeks following turn-out on pasture. Daily weight gains in the 8 weeks were for Farm I: 1216 and 1042 g/day for group EP and E (P < 0.01) and for Farm II: 1071, 671 and 770 g/day for group EP, E and Eres respectively (P < 0.001). However, liveweights were similar between groups at housing, although group EP had significantly higher liveweight at housing on Farm I (P < 0.01). Initial liveweight had effects on daily gain in the grazing season, but supplementation with energy and protein reduced this effect on Farm I. No clinical signs of coccidiosis were observed, but markedly higher levels of oocysts per gram faeces (opg) were observed on Farm II, using pastures previously grazed by cattle compared to Farm I. Calves having a maximum oocyst count above 5 000 opg were subclinically affected by coccidiosis, as indicated by low faecal dry matter and reduction in daily gain of 222 g/day (P < 0.05). It is concluded that liveweight can be increased when supplementing calves with organic concentrates rich in energy and protein in the period following turn-out compared to supplementation with barley alone. However, the overall gain at the end of the grazing season is limited due to compensatory growth in the grazing period following supplementation

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Rising rural body-mass index is the main driver of the global obesity epidemic in adults

Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities 1,2 . This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity 3�6 . Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report national, regional and global trends in mean BMI segregated by place of residence (a rural or urban area) from 1985 to 2017. We show that, contrary to the dominant paradigm, more than 55 of the global rise in mean BMI from 1985 to 2017�and more than 80 in some low- and middle-income regions�was due to increases in BMI in rural areas. This large contribution stems from the fact that, with the exception of women in sub-Saharan Africa, BMI is increasing at the same rate or faster in rural areas than in cities in low- and middle-income regions. These trends have in turn resulted in a closing�and in some countries reversal�of the gap in BMI between urban and rural areas in low- and middle-income countries, especially for women. In high-income and industrialized countries, we noted a persistently higher rural BMI, especially for women. There is an urgent need for an integrated approach to rural nutrition that enhances financial and physical access to healthy foods, to avoid replacing the rural undernutrition disadvantage in poor countries with a more general malnutrition disadvantage that entails excessive consumption of low-quality calories. © 2019, The Author(s)