Additional file 7: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S6. Protein expression of males versus females. Quantitative data on several CAA selective data was plotted with males represented as triangles and females as dots. No clear relationship between gender and protein abundance was observed. (TIF 24739 kb

Additional file 5: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S4. Clustering analysis of experimental groups and individual cases. Clustering analysis and heat maps of the different experimental groups (A) and individual cases (B) based on proteins with a significant difference (ANOVA, p < 0.05) in expression between any of the groups. (TIF 709 kb

Additional file 8: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S7. Immunoreactivity for COL6A2 is equally present in leptomeningeal vessels in control, AD and CAA tissue. (TIF 3794 kb

Additional file 6: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S5. Protein expression of CAA case #5 relative to the experimental groups and individual cases. (A) On the left the expression profile of case #5 compared to the average expression profile of the control group (2nd row), AD group (3rd row) and the CAA group (4th row). Green, expression below the overall mean; red, above the overall mean. The expression profile of case #5 is largely similar to that of the control groups but some proteins show a similar expression as in the AD and/or CAA groups. (B) Expression values (LFQ values) of several CAA specific proteins identified in this study with case #5 indicated as empty triangle pointing down. Case #5 does not differ from the CAA group in these markers. (TIF 1835 kb

Additional file 1: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S1. Coomassie blue staining of the SDS PAGE gels containing the microdissected tissue lysates. (TIF 478 kb

Additional file 4: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Table S1. Complete dataset, containing log2 transformed quantitative values (LFQ values) of all quantified proteins per individual case. (XLSX 665 kb

Additional file 2: of Proteomics analysis identifies new markers associated with capillary cerebral amyloid angiopathy in Alzheimer’s disease

Figure S2. Total protein fluorescent signal from blots used for immunoblot analysis. Total protein load was visualized using a chemidoc EZ (Bio-Rad) after electroblotting and used to obtain densitometric values which were then used to normalize for total protein input. (TIF 553 kb