NOVEL AMPHIPHILIC CHOLESTEROL-CONTAINING NANOCARRIERS FOR CREATION OF DRUG DELIVERY SYSTEMS

In the present research a synthesis and investigation of novel promising nanocarriers based on amphiphilic copolymers with prolonged resistance to biodegradation was proposed

OSTEOCONDUCTIVE COMPOSITE MATERIALS BASED ON POLY-L-LACTIDE AND NANOCRYSTALLINE CELLULOSE MODIFIED WITH POLY(GLUTAMIC ACID)

The aim of this work was to obtain the series of composite polymeric materials based on poly-L-lactide (PLLA) with different contents of hydrophilic nanocrystalline cellulose (NCC) and modified with poly(glutamic acid) (PGlu) nanocrystalline cellulose (NCC-PGlu) (5, 10 and 15 wt%) as fillers. For this purpose several methods for modifying NCC with poly(glutamic acid) were tested. The best result was demonstrated by the partial oxidation of the NCC and the subsequent interaction of the obtained aldehyde NCC groups with the terminal amino groups of PGlu.The research was carried out with the use of some equipment of the Research Park of St. Petersburg State University: “Interdisciplinary Center for Nanotechnology” and “Center for Chemical Analysis and Materials Research”