Disorders of the immune status in patients with chronic cerebral ischemia; differentiated pharmacological correction

The objective of the study is to establish the immune disorder patterns in patients with CCI I-II associated with arterial hypertension and to develop differentiated pharmacological methods for their correctio

Pharmacological correction of metabolic disorders in experimental acute pancreatitis on the background of chronic alcohol intoxication

Objective to determine the specific features of immunometabolic changes in acute pancreatitis in the context of short-term and chronic alcohol intoxication and to develop the ways of pharmacological correction of the detected violation

Instabilities of wormholes and regular black holes supported by a phantom scalar field

We test the stability of various wormholes and black holes supported by a scalar field with a negative kinetic term. The general axial perturbations and the monopole type of polar perturbations are considered in the linear approximation. Two classes of objects are considered: (i) wormholes with flat asymptotic behavior at one end and AdS on the other (M-AdS wormholes) and (ii) regular black holes with asymptotically de Sitter expansion far beyond the horizon (the so-called black universes). A difficulty in such stability studies is that the effective potential for perturbations forms an infinite wall at throats, if any. Its regularization is in general possible only by numerical methods, and such a method is suggested in a general form and used in the present paper. As a result, we have shown that all configurations under study are unstable under spherically symmetric perturbations, except for a special class of black universes where the event horizon coincides with the minimum of the area function. For this stable family, the frequencies of quasinormal modes of axial perturbations are calculated.Comment: 12 pages, 9 figures. Final version published in PRD. Eqs (29) and (30) correcte

CORRELATION ANALYSIS BETWEEN LABORATORY IMMUNE AND METABOLIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA STAGES I AND II ALONG WITH HYPERTENSION AFTER TREATMENT

Determination of interrelationships between impairments of laboratory parameters of immune and metabolic status in patients with chronic cerebral ischemia of I-II stages was carried out. The study included 104 patients, of which 76 were female and 28 males, with CCI on the background of II degree hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50 ± 5 years. Also, clinical and laboratory parameters were studied in 22 healthy donors of the same age. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL- 1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5А), the phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. Comparative assessment of the results of correlation, factorial and cluster analyzes for assessing the parameters of the immune and metabolic status in patients with stage I CCI revealed the most significant laboratory parameters necessary for determination in the clinic for objective assessment of the severity of immune and metabolic disorders: TNFα, IL-8, IL-10, SMNO and NEG. In patients with CCI stage II, to objectively assess the severity of immune and metabolic disorders, TNFα, IL-8, IL-17, IL-10, the phagocytic number of neutrophils and SEG are recommended

Split structures in general relativity and the Kaluza-Klein theories

We construct a general approach to decomposition of the tangent bundle of pseudo-Riemannian manifolds into direct sums of subbundles, and the associated decomposition of geometric objects. An invariant structure {\cal H}^r defined as a set of r projection operators is used to induce decomposition of the geometric objects into those of the corresponding subbundles. We define the main geometric objects characterizing decomposition. Invariant non-holonomic generalizations of the Gauss-Codazzi-Ricci's relations have been obtained. All the known types of decomposition (used in the theory of frames of reference, in the Hamiltonian formulation for gravity, in the Cauchy problem, in the theory of stationary spaces, and so on) follow from the present work as special cases when fixing a basis and dimensions of subbundles, and parameterization of a basis of decomposition. Various methods of decomposition have been applied here for the Unified Multidimensional Kaluza-Klein Theory and for relativistic configurations of a perfect fluid. Discussing an invariant form of the equations of motion we have found the invariant equilibrium conditions and their 3+1 decomposed form. The formulation of the conservation law for the curl has been obtained in the invariant form.Comment: 30 pages, RevTeX, aps.sty, some additions and corrections, new references adde

COMPARATIVE EFFECTIVENESS OF VARIOUS SCHEMES OF IMMUNOREHABILITATION IN INFERTILITY OF TUBOPERITONEAL GENESIS

The study aimed to compare the effectiveness of various pharmacotherapy regimens for infertility of tubo-peritoneal genesis. Under constant supervision were 96 patients referred to the hospital for diagnostic laparoscopy for infertility of tubo-peritoneal genesis, divided equally into 4 groups depending on the pharmacological treatment methods: the 1st group received basic pharmacotherapy (BPT) after endoscopic surgery (antibacterial, antifungal, vitamin therapy). Patients of groups 2-4, in addition to BPT, received Hepon, Cycloferon or Lavomax, respectively. The control group consisted of 38 gynecologically healthy women. Laboratory examination was performed within 24 hours after the operation and on the 30th day after BPT. Vaginocervical lavage and plasma were assayed for the activity of lipid peroxidation processes, the state of the antioxidant system, the level of stable nitric oxide metabolites, neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA, sIgA), components of the complement system (C3, C4, C5, C5А), phagocytic and oxygen-dependent activity of polymorphonuclear leukocytes. It was established that the use of immunomodulatory and antiviral activity medication with BPT according to the degree of increasing efficiency in the correction of immunometabolic laboratory parameters at the systemic and local level in infertility of tuboperitoneal genesis is as the following sequence: basic pharmacotherapy < basic pharmacotherapy + Hepon < basic pharmacotherapy + Cycloferon < basic pharmacotherapy + Lavomax

Quasinormal modes of d-dimensional spherical black holes with a near extreme cosmological constant

We derive an expression for the quasinormal modes of scalar perturbations in near extreme d-dimensional Schwarzschild-de Sitter and Reissner-Nordstrom-de Sitter black holes. We show that, in the near extreme limit, the dynamics of the scalar field is characterized by a Poschl-Teller effective potential. The results are qualitatively independent of the spacetime dimension and field mass.Comment: 5 pages, REVTeX4, version to be published in Physical Review

Quasi-normal modes of the scalar hairy black hole

We calculate QNMs of the scalar hairy black hole in the AdS background using Horowitz-Hubeny method for the potential that is not known in analytical form. For some black hole parameters we found pure imaginary frequencies. Increasing of the scalar field mass does not cause the imaginary part to vanish, it reaches some minimum and then increases, thus in the case under consideration the infinitely long living modes (quasi-resonances) do not appear.Comment: 17 pages, 17 figures, LaTe

Quasi-normal modes of Schwarzschild-de Sitter black holes

The low-laying frequencies of characteristic quasi-normal modes (QNM) of Schwarzschild-de Sitter (SdS) black holes have been calculated for fields of different spin using the 6th-order WKB approximation and the approximation by the P\"{o}shl-Teller potential. The well-known asymptotic formula for large $l$ is generalized here on a case of the Schwarzchild-de Sitter black hole. In the limit of the near extreme $\Lambda$ term the results given by both methods are in a very good agreement, and in this limit fields of different spin decay with the same rate.Comment: 9 pages, 1 ancillary Mathematica(R) noteboo

PERSONALIZED PHARMACOLOGICAL CORRECTION OF IMMUNE SYSTEMS, METABOLIC AND NEUROPSYCHIC PARAMETERS IN CHRONIC BRAIN ISCHEMIA OF STAGE I AND II ON THE BACKGROUND OF HYPERTENSION DISEASE

The study aimed to develop a personalized pharmacological correction of immune, metabolic and neuropsychiatric disorders in chronic cerebral ischemia (CCI) stages I and II. The study included 104 patients, of which 76 were female and 28 were male, with CCI on the background of grade II hypertension, of which 52 patients were with stage I and 52 with stage II at the age of 50±5 years. Clinical and laboratory parameters were studied in 22 healthy donors of the same age who formed a control group. Patients with CCI were randomized according to gender, age, treatment method, concomitant pathology, and duration of the disease. Evaluation of clinical and laboratory data was carried out at the beginning of treatment and 2 weeks after its end. The sorption capacity of erythrocytes and the sorption capacity of the glycocalyx (SEG), the activity of lipid peroxidation processes, the state of the antioxidant system were determined in blood plasma and erythrocytes, the level of stable metabolites of nitric oxide (SMNO), neopterin, C-reactive protein, cytokines (TNFα, IL-1β, IL-8, IFNγ, IL-18, G-CSF, IL-4, IL-10), immunoglobulins (IgM, IgG, IgA), complement system components (C3, C4, C5, C5A), phagocytic and oxygen-dependent activity of polymorphonuclear blood leukocytes. It has been established that for patients with CCI I with high concentrations of IL-8, IL-10, SMNO and a low SEG index, the intake of Cereton and Actovegin or Ceraxon and Mexicor will be insufficient for effective correction of immunometabolic disorders, which requires additional administration of an immunomodulator. Patients with CCI II, who have a higher plasma level of TNFα, IL-10 and low SEG values, need to prescribe Ceraxon, Mexicor and Glutoxim or Ceraxon, Mexicor and Polyoxidonium in order to obtain the maximum clinical and laboratory positive effect