Analysis of Career Education in a University with Low Selectivity

本稿は，選抜性の低い大学におけるキャリア教育授業の分析の試みである。授業内容は，不安定化する労働環境を踏まえたものとした。日頃の授業では，学生の個人ワークや学生と教師の質疑応答を重視し，定期的にミニレポートを課すことで学習習慣形成を促すとともに，知識定着を目指した。受講学生を対象とする調査によると，ほとんどの学生が授業に対して肯定的評価をしていた。学生の学力やキャリアレディネスと学習成果の関連を調べたところ，高校の学力が一定程度学習成果に影響を与えること，キャリアレディネスによって学びが異なることが示唆された。The current study attempted to measure learning outcomes of a career education course at a university with low selectivity. The central goal of the course was to understand unstable labor market conditions today. Students were given some time to research a topic by themselves, and then discussed it with the teacher in each class. Short essays were regularly assigned to develop a study habit and reinforce knowledge acquisition. Most students who took this course highly evaluated the experience according to our survey. The survey also shows that learning outcomes are associated with grade at high school and differ according to different level of current carrier readiness

An efficient 1,3-dipolar cycloaddition between aromatic selenoaldehydes and nitrile oxides or nitrile imines: an easy access to selenium-containing five-membered heterocyclic ring system

金沢大学大学院自然科学研究科物質創成金沢大学工学部1,3-Dipolar cycloaddition between aromatic selenoaldehydes, generated by thermal retro Diels-Alder reaction of anthracene cycloadducts, and nitrile oxides or nitrile imines proceeded efficiently to give the corresponding [3+2] cycloadducts as a single isomer in good yields, being 1,4,2-oxaselenazoles or 1,3,4-selenadiazoles, respectively. © 2007 Elsevier Ltd. All rights reserved

Runoff Model Development and Validation for Afforestation in Arid Land of Western Australia

Abstract: As a countermeasure against global warming, large scale afforestation of arid land has been done by fixing atmospheric CO 2 into plants. In arid land, however most of the rainwater is lost by runoff and evaporation. Effective use of rainwater is required for afforestation. Thus, we made an original runoff model to evaluate water distribution in a research area. In this study, we report determination of parameters in the original runoff model with Digital Elevation Model (DEM) to estimate water movement for the selection of afforestation place. From the comparison of actual and numerical results, the two sensitive parameters were decided and the characteristics of runoff water movement were elucidated hydrologically. Moreover, validation on expansion of mesh size for application of this model in large scale area was done. However, numerical results with large size mesh hadn't been approximated to small size mesh, because of roughness information of large size mesh. It was our assignment of future investigation. Keywords: Afforestation, DEM, Mesh size, Runoff, Simulation Introduction For the mitigation of global warming issue, a large scale afforestation of arid land has been promoted to fix atmospheric carbon on land which is not effectively used. Arid land area is huge in the world but the most important problem is lack of water for afforestation because of the small amount of rainfall and occurrence of runoff on soil surface. Most of runoff water is evaporated without using for plants, therefore, it is necessary to use runoff water effectively for arid land afforestation. The authors have demonstrated the improve the land condition for afforestation by introducing artificial technologies The purpose of this study is to estimate the distribution of runoff water by using the original runoff model for selection of the best afforestation places. In this report, two sensitive parameters in the original runoff model were decided to estimate water movement for the selection of afforestation place. Moreover, expansion of mesh size by using our model was validated to calculate in large scale area

A low-frequency IL4R locus variant in Japanese patients with intravenous immunoglobulin therapy-unresponsive Kawasaki disease

Background: Kawasaki disease (KD) is a systemic vasculitis which may be associated with coronary artery aneurysms. A notable risk factor for the development of coronary artery aneurysms is resistance to intravenous immunoglobulin (IVIG) therapy, which comprises standard treatment for the acute phase of KD. The cause of IVIG resistance in KD is largely unknown; however, the contribution of genetic factors, especially variants in immune-related genes, has been suspected. Methods: To explore genetic variants related to IVIG-unresponsiveness, we designated KD patients who did not respond to both first and second courses of IVIG therapy as IVIG-unresponsive patients. Using genomic DNA from 30 IVIG-unresponsive KD patients, we performed pooled genome sequencing targeting 39 immune-related cytokine receptor genes. Results: The single nucleotide variant (SNV), rs563535954 (located in the IL4R locus), was concentrated in IVIG-unresponsive KD patients. Individual genotyping showed that the minor allele of rs563535954 was present in 4/33 patients with IVIG-unresponsive KD, compared with 20/1063 individuals in the Japanese genome variation database (odds ratio = 7.19, 95% confidence interval 2.43-21.47). Furthermore, the minor allele of rs563535954 was absent in 42 KD patients who responded to IVIG treatment (P = 0.0337), indicating that a low-frequency variant, rs563535954, is associated with IVIG-unresponsiveness in KD patients. Although rs563535954 is located in the 3'-untranslated region of IL4R, there was no alternation in IL4R expression associated with the mior allele of rs563535954. However, IVIG-unresponsive patients that exhibited the minor allele of rs563535954 tended to be classified into the low-risk group (based on previously reported risk scores) for prediction of IVIG-resistance. Therefore, IVIG-unresponsiveness associated with the minor allele of rs563535954 might differ from IVIG-unresponsiveness associated with previous risk factors used to evaluate IVIG-unresponsiveness in KD. Conclusion: These findings suggest that the SNV rs563535954 could serve as a predictive indicator of IVIG-unresponsiveness, thereby improving the sensitivity of risk scoring systems, and may aid in prevention of coronary artery lesions in KD patients.ArticlePEDIATRIC RHEUMATOLOGY.17:34(2019)journal articl

The Japanese space gravitational wave antenna; DECIGO

DECi-hertz Interferometer Gravitational wave Observatory (DECIGO) is the future Japanese space gravitational wave antenna. DECIGO is expected to open a new window of observation for gravitational wave astronomy especially between 0.1 Hz and 10 Hz, revealing various mysteries of the universe such as dark energy, formation mechanism of supermassive black holes, and inflation of the universe. The pre-conceptual design of DECIGO consists of three drag-free spacecraft, whose relative displacements are measured by a differential Fabry– Perot Michelson interferometer. We plan to launch two missions, DECIGO pathfinder and pre- DECIGO first and finally DECIGO in 2024

DECIGO pathfinder

DECIGO pathfinder (DPF) is a milestone satellite mission for DECIGO (DECi-hertz Interferometer Gravitational wave Observatory) which is a future space gravitational wave antenna. DECIGO is expected to provide us fruitful insights into the universe, in particular about dark energy, a formation mechanism of supermassive black holes, and the inflation of the universe. Since DECIGO will be an extremely large mission which will formed by three drag-free spacecraft with 1000m separation, it is significant to gain the technical feasibility of DECIGO before its planned launch in 2024. Thus, we are planning to launch two milestone missions: DPF and pre-DECIGO. The conceptual design and current status of the first milestone mission, DPF, are reviewed in this article

Identification of a high incidence region for retroviral vector integration near exon 1 of the LMO2 locus

Therapeutic retroviral vector integration near the oncogene LMO2 is thought to be a cause of leukemia in X-SCID gene therapy trials. However, no published studies have evaluated the frequency of vector integrations near exon 1 of the LMO2 locus. We identified a high incidence region (HIR) of vector integration using PCR techniques in the upstream region close to the LMO2 transcription start site in the TPA-Mat T cell line. The integration frequency of the HIR was one per 4.46 × 10(4 )cells. This HIR was also found in Jurkat T cells but was absent from HeLa cells. Furthermore, using human cord blood-derived CD34(+ )cells we identified a HIR in a similar region as the TPA-Mat T cell line. One of the X-linked severe combined immunodeficiency (X-SCID) patients that developed leukemia after gene therapy had a vector integration site in this HIR. Therefore, the descriptions of the location and the integration frequency of the HIR presented here may help us to better understand vector-induced leukemogenesis