123 research outputs found
Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy
Continuous Hydrolysis and LiquidâLiquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator
Hybrid Approach in Microscale Transport Phenomena: Application to Biodiesel Synthesis in Micro-reactors
A hybrid engineering approach to the study of transport phenomena, based on the
synergy among computational, analytical, and experimental methodologies is
reviewed. The focus of the chapter is on fundamental analysis and proof of concept
developments in the use of nano- and micro-technologies for energy efficiency and
heat and mass transfer enhancement applications. The hybrid approach described
herein combines improved lumped-differential modeling, hybrid numericalanalytical solution methods, mixed symbolic-numerical computations, and
advanced experimental techniques for micro-scale transport phenomena. An
application dealing with micro-reactors for continuous synthesis of biodiesel is
selected to demonstrate the instrumental role of the hybrid approach in achieving
improved design and enhanced performance
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