Exacerbating Mindless Compliance: The Danger of Justifications during Privacy Decision Making in the Context of Facebook Applications

Online companies exploit mindless compliance during users’ privacy decision making to avoid liability while not impairing users’ willingness to use their services. These manipulations can play against users since they subversively influence their decisions by nudging them to mindlessly comply with disclosure requests rather than enabling them to make deliberate choices. In this paper, we demonstrate the compliance-inducing effects of defaults and framing in the context of a Facebook application that nudges people to be automatically publicly tagged in their friends’ photos and/or to tag their friends in their own photos. By studying these effects in a Facebook application, we overcome a common criticism of privacy research, which often relies on hypothetical scenarios. Our results concur with previous findings on framing and default effects. Specifically, we found a reduction in privacy-preserving behaviors (i.e., a higher tagging rate in our case) in positively framed and accept-by-default decision scenarios. Moreover, we tested the effect that two types of justifications—information that implies what other people do (normative) or what the user ought to do (rationale based)— have on framing- and default-induced compliance. Existing work suggests that justifications may increase compliance in a positive (agree-by-) default scenario even when the justification does not relate to the decision. In this study, we expand this finding and show that even a justification that is opposite to the default action (e.g., a justification suggesting that one should not use the application) can increase mindless compliance with the default. Thus, when companies abide by policy makers’ requirements to obtain informed user consent through explaining the privacy settings, they will paradoxically induce mindless compliance and further threaten user privacy

Reducing Default and Framing Effects in Privacy Decision-Making

Framing and default effects have been studied for more than a decade in different disciplines. A common criticism of these studies is that they use hypothetical scenarios. In this study, we developed a real decision environment: a Facebook application in which users had to decide whether or not they wanted to be automatically publicly tagged in their friends’ pictures and/or tag their friends in their own pictures. To ensure ecological validity, participants had to log in to their Facebook account. Our results confirmed previous studies indicating a higher tagging rate in positively framed and accept-by-default conditions. Furthermore, we introduced a manipulation that we assumed would overshadow and thereby reduce the effects of default and framing: a justification highlighting a positive or negative descriptive social norm or giving a rationale for or against tagging. We found that such justifications may at times increase tagging rates

Explaining recommendations in an interactive hybrid social recommender

Hybrid social recommender systems use social relevance from multiple sources to recommend relevant items or people to users. To make hybrid recommendations more transparent and controllable, several researchers have explored interactive hybrid recommender interfaces, which allow for a user-driven fusion of recommendation sources. In this field of work, the intelligent user interface has been investigated as an approach to increase transparency and improve the user experience. In this paper, we attempt to further promote the transparency of recommendations by augmenting an interactive hybrid recommender interface with several types of explanations. We evaluate user behavior patterns and subjective feedback by a within-subject study (N=33). Results from the evaluation show the effectiveness of the proposed explanation models. The result of post-treatment survey indicates a significant improvement in the perception of explainability, but such improvement comes with a lower degree of perceived controllability

Using latent features diversification to reduce choice difficulty in recommendation lists

Ail important side effect of using recoinmender systems is a phenomenon called "choice overload"; the negative feeling incurred by the increased difficulty to choose from large sets of high quality recommendations. Choice overload has traditionally been related to the size of the item set, but recent work suggests that the diversity of the item set is an important moderator. Using the latent feanires of a matrix factorization algorithm, we were able to manipulate the diversity of the items, while controlling the overall attractiveness of the list of recommendations. In a user study, participants evaluated personalized item lists (varying in level of diversity) on perceived diversity and attractiveness, and their experienced choice difficulty and tradeoff difficulty. The results suggest that diversifying the recommendations might be an effective way to reduce choice overload, as perceived diversity and attractiveness increase with item set diversity, subsequently resulting in participants experiencing less tradeoff difficulty and choice difficulty.</p

Comprehensive diagnostics of acute myeloid leukemia by whole transcriptome RNA sequencing

Acute myeloid leukemia (AML) is caused by genetic aberrations that also govern the prognosis of patients and guide risk-adapted and targeted therapy. Genetic aberrations in AML are structurally diverse and currently detected by different diagnostic assays. This study sought to establish whole transcriptome RNA sequencing as single, comprehensive, and flexible platform for AML diagnostics. We developed HAMLET (Human AML Expedited Transcriptomics) as bioinformatics pipeline for simultaneous detection of fusion genes, small variants, tandem duplications, and gene expression with all information assembled in an annotated, user-friendly output file. Whole transcriptome RNA sequencing was performed on 100 AML cases and HAMLET results were validated by reference assays and targeted resequencing. The data showed that HAMLET accurately detected all fusion genes and overexpression of EVI1 irrespective of 3q26 aberrations. In addition, small variants in 13 genes that are often mutated in AML were called with 99.2% sensitivity and 100% specificity, and tandem duplications in FLT3 and KMT2A were detected by a novel algorithm based on soft-clipped reads with 100% sensitivity and 97.1% specificity. In conclusion, HAMLET has the potential to provide accurate comprehensive diagnostic information relevant for AML classification, risk assessment and targeted therapy on a single technology platform

Correlation of gene expression and protein production rate - a system wide study

<p>Abstract</p> <p>Background</p> <p>Growth rate is a major determinant of intracellular function. However its effects can only be properly dissected with technically demanding chemostat cultivations in which it can be controlled. Recent work on <it>Saccharomyces cerevisiae </it>chemostat cultivations provided the first analysis on genome wide effects of growth rate. In this work we study the filamentous fungus <it>Trichoderma reesei </it>(<it>Hypocrea jecorina</it>) that is an industrial protein production host known for its exceptional protein secretion capability. Interestingly, it exhibits a low growth rate protein production phenotype.</p> <p>Results</p> <p>We have used transcriptomics and proteomics to study the effect of growth rate and cell density on protein production in chemostat cultivations of <it>T. reesei</it>. Use of chemostat allowed control of growth rate and exact estimation of the extracellular specific protein production rate (SPPR). We find that major biosynthetic activities are all negatively correlated with SPPR. We also find that expression of many genes of secreted proteins and secondary metabolism, as well as various lineage specific, mostly unknown genes are positively correlated with SPPR. Finally, we enumerate possible regulators and regulatory mechanisms, arising from the data, for this response.</p> <p>Conclusions</p> <p>Based on these results it appears that in low growth rate protein production energy is very efficiently used primarly for protein production. Also, we propose that flux through early glycolysis or the TCA cycle is a more fundamental determining factor than growth rate for low growth rate protein production and we propose a novel eukaryotic response to this i.e. the lineage specific response (LSR).</p