Causal ACTH-Depot Therapy during Pregnancies following Infertility Treatment

The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones are free from unwanted side effects of their synthetics analogs. Low level of maternal blood ACTH and insufficient increase of induced by hypothalamic hormones oxytocinases (cystine-β-aminopeptidases) were indication to ACTH-depot therapy (0.5 mg/week) in our consecutive prospective studies. Contrary to antenatal use of synthetic corticosteroids, there are no temporal limits of this therapy, which has to be more often recommended into clinical prevention of fetal morbidity, treatment of premature delivery, and finally elimination of the newborn's mortality caused by the neuroendocrinological gestoses

The selected labour pre-induction and induction methods used in Krakow hospitals

The contemporary medical science provides various methods of labour induction: labour pre-induction and induction, which are determined by the obstetric situation and cervical ripening. A number of factors influence the effectiveness of labour induction and pre-induction. The choice of a suitable method should be guided by the well-being of the mother and child. Evaluation of selected labour pre-induction and induction methods pharmacological and non-pharmacological used in Krakow hospitals. The study included 271 patients admitted to Cracow hospitals to undergo childbirth, in whom various methods of labour pre-induction and induction were used. Diagnostic survey method was applied in the study, the tool being an original questionnaire used to analyze medical records. The statistical analysis was done with IBMSPSS Statistics version 19.0. 92.2% of patients who received oxytocin infusion drip and 83.3% of patients who received oxytocin infusion drip with the Foley catheter felt pain. In the other groups the proportion was below 50%. The observed differences between the groups were statistically significant (p < 0.001). In examining the impact of the methods used on the way childbirth was completed, in multivariate logistic regression model, statistical significance of none of the analyzed method was confirmed. The results indicate that labour pre-induction and induction which applies the selected methods is effective in physiological childbirth induction and all the methods are, to a similar extent, safe for mother and child