Synthesis of Polyfluoroalkyl-Containing 7-(4-Phenyl-1h-1,2,3-Triazol-1-Yl)-6,7-Dihydro-1н-Indazol-4(5н)-Оnes

This paper is devoted to synthesis of triazolyl derivatives of tetrahydroindazoles. Special attention is addressed to synthesis of fluorine containing congeners

A Facile Synthesis of 4-Acylamino-Tetrahydroindazoles via the Ritter Reaction

A new route toward 4-acylamino- and 4-amino-substituted tetrahydroindazoles is disclosed. The title compounds are obtained in good to excellent yields in the Ritter reaction between 4-hydroxy-tetrahydroindazoles and various nitriles. The reactivity of the tetrahydroindazole-derived carbenium ion is both sufficiently high to react with trichloroacetonitrile and sufficiently selective to resist the azide functionality within its structure. The present approach adds a method to the toolbox of tetrahydroindazole chemistry and facilitates the structural modifications of the scaffold, which has found important applications in medicinal chemistry

Synthesis of Chiral 4-Amino- and 7-Amino-Tetrahydroindazoles and Transformations thereof

This paper describes resolution of racemic amino-tetrahydroindazoles into pure enantiomer

Practical Synthesis of Enantiopure 4-Amino- and 7-Amino- Tetrahydroindazoles and Transformations thereof

This conference abstract describes the chiral resolution of amino-tetrahydroindazole