ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris : a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Funding This work was supported by the ICMR (AMR/149/2018-ECD-II) and DBT (BT/PR14117/BRB/10/1420/2015) to RP. AKM appreciates the support by research grant EMR/2016/001927 and DST PURSE II from the Department of Science and Technology (IN). MW was grateful for a Senior Research Fellowship from the University Grant Commission. NG acknowledges the Wellcome Trust support of a Senior Investigator (101873/Z/13/Z), Collaborative (200208/A/15/Z), and Strategic Awards (097377/Z11/Z), and the MRC Centre for Medical Mycology (MR/N006364/1). AJM was supported by the University of Aberdeen studentship. Work in AL’s laboratory was supported by the Wellcome Trust (212524/Z/18/Z) and the Medical Research Council (MRC) Centre for Medical Mycology at the University of Aberdeen (MR/P501955/1 and MR/N006364/1). Acknowledgments We thank the Centre for Genome Enabled Biology and Medicine at the University of Aberdeen (E. Collie-Duguid and S. Shaw) for sequencing and support with genome analysis.Peer reviewedPublisher PD

Studies on novel polycyclic heterocycles: synthesis of new naphthaquinoxaline and naphthazaquinoxaline derivatives from naturally occurring quinones

427-433A facile synthesis of novel polycyclic heterocycles namely naphthaquinoxaline and naphthazaquinoxaline derivatives is carried out by the reaction of lapachol and β-lapachone, naturally occurring naphthoquinones with o-phenylene diamine and 2,3-diaminopyridine. Regioselectivity in the reaction of β-lapachone with 2,3-diaminopyridine is confirmed by single crystal X-ray diffraction of a representative compound 6,7-dihydro-8,8-dimethyl-8H-pyrano[3',2':4]-naphtha[2,1-e]pyrido[2,3-b]pyrazine; C₂₀H₁₇N₃O, crystallizes as orthorhombic in the space group Pbca with cell parameters a =9.793(3)Å, b=17.514(6)Å, c=18.334(6)Å, V=3144.5(17) ų, Z=8,1.332 mg/m³, R₁=0.3076, WR₂=0.3595

Facile chemoselective synthesis of novel 6-aryl-12<i style="">H</i>-indolo[2,3-<i style="">e</i>][1,4]benzodiazocine derivatives by the reaction of 3-aroylmethylene-2<i style="">H</i>-indol-2-ones with <i style="">o</i>-phenylenediamine

1135-1139 Syntheses of 6-aryl-12H-indolo[2,3-e][1,4]benzodiazocine deri­vatives 8 have been achieved for the first time by the reaction of 3-aroylmethylene-2H-indol-2-ones 4 with o-phenylenediamine 5 While the analogous reaction of 4 with ethylene diamine 9 resulted in exclusive formation of Schiff base derivatives viz. 1,3-dihydro-3-[2- (2-aminoethylimino)-2-aryl-ethylidene]indol-2-ones 12. The structures are assigned with the help of analytical and 1H, 13C NMR, DEPT, IR and mass spectral studies.</smarttagtype

Radermachol and naphthoquinone derivatives from Tecomella undulata: Complete ¹H and ¹³C NMR assignments of radermachol with the aid of computational ¹³C shift prediction

1865-1870Petroleum ether extract of the heartwood of Tecomella undulata affords radermachol, an unusual rare pigment and 2-isopropenylnaphtho[2,3-b]furan-4,9-quinone along with lapachol, tecomaquinone-I, dehydro-α-lapachone, α-lapachone, β-lapachone, cluytyl ferulate, stigmasterol and β-sitosterol. Radermachol and 2-isopropenylnaphtho [2,3-b]furan-4,9-quinone are being reported for the first time from genus Tecomella. Complete assignments of ¹H and ¹³C NMR signals of polyketide, radermachol 1, have been achieved by the ¹³C NMR chemical shift prediction using ab initio MO and DFT/GIAO methods in addition to 2D-NMR techniques

Exploring the pharmacological and chemical aspects of pyrrolo-quinazoline derivatives in Adhatoda vasica

Adhatoda or Justicia is one of the biggest and complex genera of the Acanthaceae family. Adhatoda vasica is commonly known as ‘Adosa’. It is an ayurvedic medicine with a medicinal history of more than a thousand years in India. Traditionally, it is used to treat cough, asthma, phlegm, bleeding hemorrhoids, for both adults and youth. This plant possesses antiarthritis, antiseptic, antimicrobial, anti-tuberculosis, anti-inflammatory and abortifacient properties. Alkaloids are the major phytoconstituents present in the plant in the form of pyrrolo-quinazoline derivatives viz vasicine, vasicinone, vasicinol, adhatodine, adhatodinine, adhavasinone and anisotine etc. The asserted objectives are to conduct a systematic review on the phytochemistry, pharmacology and traditional uses of A. vasica, as well as highlighting the challenges found in the research. This will promote the utilization of A. vasica at extract level and further development of new drug leads based on the compounds isolated and used for treatment of various ailments. The present review covers the literature survey from 1888 to 2023. The relevant data has been collected from various peer-reviwed journals, and books via Sci-Finder, PubMed, Science Direct, Google Scholar, EBSCO, online electronic journals, SpringerLink and Wiley. This paper aims to present a systematic review of known traditional applications, pharmacological and chemical aspects in Adhatoda vasica

Conservation Agriculture for Sustainable Agriculture

The paper is centered on the concept of conservation agriculture (CA), which is defined as a sustainable cultivation system for the future. Conservation agriculture (CA) is a sustainable farming system that promotes minimal soil disturbance, permanent soil cover, and crop rotations to maintain soil health and productivity. This approach focuses on maximizing natural resources, reducing inputs, and improving the efficiency of nutrient use. CA practices have been found to reduce soil erosion, conserve water, and increase soil organic matter, leading to improved crop yields and reduced greenhouse gas emissions. In addition to improving agricultural productivity, CA can also contribute to broader sustainable development goals, including poverty reduction, food security, and biodiversity conservation. However, the adoption of CA requires a shift in mindset and significant investment in equipment, training, and research. Conservation agriculture (CA) started in 1930 and it didn’t gain popularity till 1950. But from 1950 to 1990, there was very little rise- CA was practiced in only 2-million-hectare land. From 1990 to 2015, CA was practices in almost 180- million-hectare land with 10-million hectare annually around the world. The places where CA is practiced the most is Brazil, next is America followed by Australia. In India, CA is practiced at 3-million-hectare land in different forms. Various types of machinery and techniques are used in conservation agriculture such as zero tillage, crop diversification and intensification, multi crop zero tillage plant, mechanical transplanter, happy seeder and laser land leveler. The use of machinery in CA has several benefits, including improved soil health, increased crop yields, and reduced labor and input costs. However, the adoption of CA machinery requires significant investment in equipment and training, and there may be limitations in some regions due to soil conditions and crop types. However, promoting CA technologies still faces challenges such as the lack of appropriate seeders for small-scale farmers, competition between CA use and livestock feeding for crop residues, burning of crop residues, a shortage of skilled manpower, and overcoming the traditional mindset about tillage. Drawback of conservation agriculture is Limited adoption, limited knowledge and skills, dependence on herbicide and initial investment costs and so on

Primary renal leukaemia in a young adult male as an extramedullary presentation of T cell acute lymphoblastic leukaemia

Abstract Primary renal involvement by T lymphoblasts is rare among adults with T acute lymphoblastic leukaemia. We report a 28‐year‐old man presenting with acute renal failure due to infiltration by T lymphoblasts and his response to paediatric‐inspired modified BFM‐90 protocol. The patient achieved an initial complete remission (CR) but developed central nervous system relapse. He achieved CR2 with cranial irradiation and intrathecal chemotherapy. He underwent a haploidentical transplant in CR2 and remains in remission post‐transplant day 330. An early kidney biopsy helped confirm the diagnosis. Such presentations remain responsive to modified BFM‐90. An early allotransplant in CR2 remains the standard of care