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Twelve Hour Longevity of the Oral Malodor-Neutralizing Capacity of an Oral Rinse Product Containing the Chlorine Dioxide Precursor Sodium Chlorite
open access articleObjectives: The objectives of this investigation were to investigate the effectiveness and longevity of an oral rinse product containing 0.10% (w/v) of the chlorine dioxide precursor sodium chlorite (1) on oral malodor in participants throughout a 12 h daylight diurnal cycle.
Materials and methods: Thirty healthy participants (17 male, 13 female) were recruited to the study. Volatile sulfur compound levels (VSCs: H2S, CH3SH and (CH3)2S) were simultaneously monitored in their oral cavity air samples both before (0 h) and at 0.33, 4, 8 and 12 h after using the above oral rinse, or water as a negative control (participants refrained from oral hygiene measures during this 12 h period). The experimental
design for this cross-over investigation was a mixed model ANOVA-based system incorporating treatments, sampling time-points and participants, together with their first-order interactions, as components of variance.
Results: Results acquired demonstrated that the oral rinse formulation effectively suppressed VSC production in the oral environment for 12 h periods (p<0.0001, 0.0001 and 0.002 for H2S, CH3SH and (CH3)2S respectively). Mean 0 vs 12 h reductions in oral cavity H2S and CH3SH concentrations were much greater than those observed for the H2O negative control (p<10-8), but not so for (CH3)2S. Principal component analysis
(PCA) a H2S/CH3SH linear combination and (CH3)2S alone significantly loaded on the first and second separate orthogonal components respectively, an observation confirming differing sources for these variable sets.
Conclusions: The oral rinse explored effectively blocked VSC production in the oral cavity for a period of 12 h. This extended efficacy duration is likely to be ascribable to the ability of its active ClO2- ingredient to exert a combination of biochemical (direct VSC- and amino acid VSC precursor-consuming) and microbicidal actions in vivo.
Clinical relevance: The 12 h longevity of product’s# oral malodor-neutralizing actions is of much clinical significance in view of the involvements of VSCs, particularly CH3SH, in the pathogenesis of gingivitis and periodontiti
Modeling Provider Knowledge, Skills, and Abilities (KSA)
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