Comparison of HAV positive and negative patients presenting with uncomplicated <i>P. falciparum</i> malaria.

<p>Geometric mean parasitemia at baseline were</p>∞<p>31,000 (15,000–63,000) and</p>†<p>34,000 (24,000–47,000) when patients with high parasitemia are excluded.</p>#<p>T-test,</p><p>*Mann-Whitney test,</p>§<p>chi square test.</p

Summary of key laboratory parameters of patients who presented with uncomplicated <i>P. falciparum</i> malaria and subsequently found to have anti-HAV IgM indicating acute HAV infection.

1<p>One-third of patients were enrolled in May 2006.</p

95% reference ranges with 90% confidence intervals for selected white blood cells parameters for Kilifi children aged 1–17 months.

<p>95% reference ranges with 90% confidence intervals for selected white blood cells parameters for Kilifi children aged 1–17 months.</p

95% reference ranges with 90% confidence intervals for selected haematological parameters for Kilifi children aged 1–17 months.

<p>95% reference ranges with 90% confidence intervals for selected haematological parameters for Kilifi children aged 1–17 months.</p

Participant flow diagram.

<p>Participant flow diagram.</p

95% reference ranges with 90% confidence intervals for selected biochemistry parameters for Kilifi children aged 1–17 months.

<p>95% reference ranges with 90% confidence intervals for selected biochemistry parameters for Kilifi children aged 1–17 months.</p

95% reference intervals for selected haematological parameters: Kenyan infants aged 1 to less than 12 months (current study), compared to published data from Tanzania and United States/Europe.

<p>95% reference intervals for selected haematological parameters: Kenyan infants aged 1 to less than 12 months (current study), compared to published data from Tanzania and United States/Europe.</p

95% reference intervals for white blood cell counts for Kenyan infants aged 1 to less than 12 months, compared to published data from Tanzania and United States/Europe.

<p>95% reference intervals for white blood cell counts for Kenyan infants aged 1 to less than 12 months, compared to published data from Tanzania and United States/Europe.</p

Flow diagram of participant numbers.

<p>Participant numbers and reasons for exclusion at each stage are shown.</p

Regression model prediction and variability explained by the predictors of the model.

<p>Panel A shows the predicted probability of a positive slide result (<i>y</i>-axis) against the prevalence of ITN use in a 2 km radius around each admitted child’s residence (shaded area represents 95% CI). Panel B shows the pseudo R² of the various variables assessed in the extended model (ITN use around a child’s residence, EVI, age, age–time interaction, time, region, and location). We repeated our analysis using a cut-off of >2,500 parasites per μl. The same patterns were seen—i.e., a pattern of a postdecline increase in MPF among older children (<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002047#pmed.1002047.s006" target="_blank">S6 Fig</a>), and an inverse relationship between MPF and age of malaria (r = −0.63, <i>p</i> < 0.001) and a pattern of protection by community-level ITN use (<a href="http://www.plosmedicine.org/article/info:doi/10.1371/journal.pmed.1002047#pmed.1002047.s007" target="_blank">S7 Fig</a>). These patterns remained statistically significant.</p