34 research outputs found
Additive Intraocular Pressure Lowering Effects of the Rho Kinase Inhibitor, Ripasudil in Glaucoma Patients Not Able to Obtain Adequate Control After Other Maximal Tolerated Medical Therapy
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Stepwise multiple regression analysis for factors associated MT.
Stepwise multiple regression analysis for factors associated MT.</p
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PurposeOptic nerve head (ONH) blood flow decrease without changes in intraocular pressure in a possible rat model of retinal ganglion cell loss by systemic administration of aldosterone. To compare the blood flow in the ONH, using laser speckle flowgraphy (LSFG), in healthy eyes and in eyes with primary aldosteronism (PA).MethodsThe ONH tissue area mean blur rate (MT) was evaluated in this single center, retrospective, cross-sectional study using LSFG. In order to compare the MT between PA patients and normal subjects, mixed-effects models were used, with adjustments made for the mean arterial pressure, disc area, and β-peripapillary atrophy (β-PPA) area. Mixed-effects models were also used to analyze the risk factors affecting the MT.ResultsThis study evaluated a total of 29 eyes of 17 PA patients and 61 eyes of 61 normal subjects. There was a significantly lower MT in PA patients (10.8 ± 0.4) as compared to the normal subjects (12.3 ± 0.3) (P = 0.004). The MT was significantly lower in PA patients (10.8 ± 0.6) even after adjusting for the potential confounding factors when compared to normal subjects (12.3 ± 0.3) (P = 0.046). Multivariate mixed-effects model analysis demonstrated that the MT was significantly associated with the PA and β-PPA.ConclusionsThere was a significantly lower ONH blood flow in PA patients as compared to normal subjects.</div
Scatterplots showing the relationship between MT and plasma aldosterone concentration.
Scatterplots showing the relationship between MT and plasma aldosterone concentration.</p
OCT measurements and visual field sensitivity an accordance with the severity of glaucoma.
<p>OCT measurements and visual field sensitivity an accordance with the severity of glaucoma.</p
Clinical characteristics of normal subjects and primary aldosteronism patients.
Clinical characteristics of normal subjects and primary aldosteronism patients.</p
Clinical characteristics of the study population.
<p>Clinical characteristics of the study population.</p
GCA thickness for the average, superior hemifield average, and inferior hemifield average.
<p>GCA thickness for the average, superior hemifield average, and inferior hemifield average.</p