AXL expression in LADs by IHC.

<p>AXL expression status was classified in four categories, 0 (negative, A), 1+ (weak, B), 2+ (moderate, C), and 3+ (strong, D). All images include vascular endothelial cells, which were used as internal controls.</p

Results of target sequencing for 22 genes in AXL 3+-expressing lung adenocarcinomas from 12 patients.

<p>Results of target sequencing for 22 genes in AXL 3+-expressing lung adenocarcinomas from 12 patients.</p

Overall survival of the patients based on AXL expression status.

<p>Overall survival rates correlated with AXL expression status. The group of patients whose specimens showed strong AXL expression (3+ intensity) showed markedly shorter survival than groups whose specimens showed weaker intensity (0, 1+ or 2+; <i>P</i> = 0.0033; log-rank test). 5ysr: 5-year survival rates.</p

Relationships between AXL expression and markers for EMT and CSCs.

<p>Relationships between AXL expression and markers for EMT and CSCs.</p

Relationships between AXL expression and clinical factors in 161 LAD specimens.

<p>Relationships between AXL expression and clinical factors in 161 LAD specimens.</p

A case of AXL 3+-expressing lung adenocarcinoma that responded well to gefitinib.

<p>(A) Pre-treatment and (B) post-treatment (6 months after initiation of gefitinib, CT scans are shown.</p

Typical cell images for clustered cells composed of more than three cells in cancer cell-implanted and control blood.

<p>Each data count (<i>n</i>) indicates the image number having the same cluster size and <i>N_n</i>. Bars, 20 µm.</p

An example of cell sorting.

<p>Two photographs of the discarded reservoir (a) and the collection reservoir (b) indicated in the chip photograph are shown. Clustered cells are indicated by white arrows. Bars, 100 µm.</p

Additional file 1: of Ciliated muconodular papillary tumors of the lung with KRAS/BRAF/AKT1 mutation

Antibodies used for immunohistochemistry. (XLSX 10 kb

Summary of the number of nuclei, <i>N_n</i>.

<p>(a) A histogram of <i>N_n</i> obtained from cancer cell-implanted and control blood. (b) The relationship between <i>N_n</i> and cell cluster size.</p