4 research outputs found
Π ΠΎΠ»Ρ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π‘677Π’ Π³Π΅Π½Π° MTHFR Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΠ‘ ΠΈ Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠΌΠΈ
The present study was designed to determine the possibility of the application the genotyping of the patients with dislipidaemia as an additional factor for the prediction of the cardiovascular complications. The distribution of the polymorphism C677T of the gene MTHFR among the 62 patients with dislipidaemia was studied. Allele-specific PCR was applied for detection the C677T mutation/ These results provide the genetic evidence that 677T allele of the gene MTHFR correlates with the development of the complications of the coronary heart disease for the patients with dislipidaemia (p = 0,01). It was demonstrated that more complex and durable antihypertension and cardiotropic therapy must be applicated for the carries of the 677T allele among the dislipidaemia patients. These data indicate the appreciable role C677T polymorphism of MTHFR for the decreasing of the cardiovascular complications among the patients with dislipidaemia and for detection the complexity and longevity of the medical treatments.Π Π°Π±ΠΎΡΠ° ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»Π°ΡΡ Ρ ΡΠ΅Π»ΡΡ ΠΎΡΠ΅Π½ΠΊΠΈ ΠΏΡΠΎΠ³Π½ΠΎΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ ΠΏΠΎΠ»ΠΈΠΌΠΎΡΡΠΈΠ·ΠΌΠ° Π‘677Π’ Π³Π΅Π½Π° ΠΌΠ΅ΡΠΈΠ»Π΅Π½ΡΠ΅ΡΡΠ°Π³ΠΈΠ΄ΡΠΎΡΠΎΠ»Π°ΡΡΠ΅Π΄ΡΠΊΡΠ°Π·Ρ (MTHFR) Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠΠ‘ ΠΈ Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠΌΠΈ. ΠΠ»Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΠΌΡΡΠ°ΡΠΈΠΈ Π‘677Π’ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ Π°Π»Π»Π΅Π»Ρ-ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΠ¦Π . ΠΡΠ»Π° Π²ΡΡΠ²Π»Π΅Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²ΠΎΠΌ ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ 677Π’ ΠΈ ΡΠ°ΡΡΠΎΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΠΠ‘ Π² ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΠΎΠΉ Π³ΡΡΠΏΠΏΠ΅ Π±ΠΎΠ»ΡΠ½ΡΡ
(Ρ = 0,01). ΠΠ»Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠΌΠΈ Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ Π·Π½Π°ΡΠΈΠΌΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ Π½ΠΎΡΠΈΡΠ΅Π»ΡΡΡΠ²ΠΎΠΌ ΠΌΡΡΠ°Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π»Π»Π΅Π»Ρ 677Π’ Π³Π΅Π½Π° MTHFR ΠΈ ΡΠ°ΡΡΠΎΡΠΎΠΉ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΠΈ ΠΈΠ½ΡΠ΅Π½ΡΠΈΠ²Π½ΠΎΡΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ (Ρ = 0,8). ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΠΌΠ΅ΡΡ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠ΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ Π΄Π»Ρ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΡ ΡΠΈΡΠΊΠ° ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ³ΠΎ ΠΈ Π½Π΅ΡΡΠ°Π±ΠΈΠ»ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π΄ΠΈΡΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π΄Π»Ρ Π²ΡΠ±ΠΎΡΠ° ΠΎΠ±ΡΠ΅ΠΌΠ° ΠΈ ΠΏΡΠΎΠ΄ΠΎΠ»ΠΆΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΈ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π³ΠΈΠΏΠΎΠ»ΠΈΠΏΠΈΠ΄Π΅ΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ²
Arterial hypertension and coronary heart diseases development in patients with dyslipoproteinemia against polymorphisms of gp iiia genes and prothrombin gene
The cause of a genetic predisposition to a variety of diseases, including coronary atherosclerosis and coronary heart disease is the presence of defective integrin receptors on the cell surfaces, as well as thrombophilia associated also with prothrombin gene mutations. This paper deals with the study of frequency of alleles of one of the integrins, GPIIIa glycoprotein (Ξ²- type III subunit), and prothrombin gene in patients with dyslipidemia. We have established that the presence of allele PLA2 of GPIIIa gene and allele G20210A of prothrombin gene in the genotype of a patient is a genetic risk factor for intensive development of coronary heart disease and hypertension in patients with dyslipidemia, which is associated with a higher incidence of complications and the need for carrying out more comprehensive antihypertensive therapy to stabilize blood pressure
Arterial hypertension and coronary heart diseases development in patients with dyslipoproteinemia against polymorphisms of gp iiia genes and prothrombin gene
The cause of a genetic predisposition to a variety of diseases, including coronary atherosclerosis and coronary heart disease is the presence of defective integrin receptors on the cell surfaces, as well as thrombophilia associated also with prothrombin gene mutations. This paper deals with the study of frequency of alleles of one of the integrins, GPIIIa glycoprotein (Ξ²- type III subunit), and prothrombin gene in patients with dyslipidemia. We have established that the presence of allele PLA2 of GPIIIa gene and allele G20210A of prothrombin gene in the genotype of a patient is a genetic risk factor for intensive development of coronary heart disease and hypertension in patients with dyslipidemia, which is associated with a higher incidence of complications and the need for carrying out more comprehensive antihypertensive therapy to stabilize blood pressure