Additional file 3: Figure S3. of Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins

Frequency of occurrence of specific class 2 and 3 PDZ ligand motifs in the cytoplasmic domains of 99 MHCI proteins from 21 species. A. Class 2 PDZ ligand motifs ([ΦXΦ], where Φ = V, I, L, M, F, W, or C), or B. class 3 PDZ ligand motifs ([D/E X Φ) [46]) in the cytoplasmic domains of 99 MHCI proteins from 21 species (data used to create pie charts in Fig. 2e and f, respectively). Shown are the number of occurrences of each motif as well as the fraction they represent of the total motifs observed in each domain. Class 2 PDZ ligand forms that were never observed in either domain are not shown. (PPTX 73 kb

Additional file 1: Figure S1. of Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins

Categorization of PDZ ligands. The current study made use of forms of Lenfant et al.’s [44] and Nourry et al.’s [46] criteria to identify potential PDZ ligand motifs in MHCI proteins. Related rules were proposed in [45]. (PPTX 35 kb

Additional file 2: Figure S2. of Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins

PDZ ligand motifs identified in the cytoplasmic domains of 16 mouse MHCI and MHCI-like proteins. Putative PDZ ligand motifs are highlighted in red, and previously noted conserved serines and tyrosine (see text) are underlined in bold. Consensus motifs: class 1 PDZ, [S/T X Φ]; class 2 PDZ, [ΦXΦ]; class 3 PDZ, [D/E X Φ]; Φ = Y, F, W, C, M, V, I, L, or A [44]. H2-T23 is also known as Qa-1. No ligand motifs were found in the cytoplasmic domain of H2-M2 or -M9, and therefore they are omitted. Soluble MHCI proteins including H2-Q10 lack a cytoplasmic domain and were not considered in this analysis. (PPTX 37 kb