38 research outputs found
Another Small Supernumerary Marker Chromosome Derived From Chromosome 9 in a Klinefelter Patient Otro Cromosoma Marcador Supernumerario Pequeño Derivado del Cromosoma 9 en un Paciente con el Síndrome de Klinefelter CASE REPORTS
ABSTRAC
Assessment of hand function and disability in fibromyalgia
Serdaroglu Beyazal, Munevver/0000-0001-5903-5708WOS: 000494049400012PubMed: 30324279Objective. Fibromyalgia, a potentially debilitating chronic pain syndrome, is a chronic disease. We aimed to compare the hand function of fibromyalgia (FM) patients and healthy individuals and to demonstrate the relationship between hand disability and FM. Patients and methods. the study was consisted of 40 female patients with FM and 30 healthy controls. All participants were evaluated for pain threshold measurements, handgrip strength, and pinch strength. Functional states, hand disability, and hand skills and coordination were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) form, the Disability of Arm-Shoulder-Hand (DASH) questionnaire and the Purdue Pegboard Test, respectively. Results. Handgrip strength values, DASH score, lateral pinch strength test, Pegboard placement time, and Pegboard collection time of the patient group were significantly lower than those of the control group (all p < 0.05). A negative correlation was found between FIQ score and handgrip strength, two-point pinch strength test, three-point pinch strength test, and lateral pinch strength test in patients with moderate FM (all p < 0.05). Furthermore, a correlation was observed between DASH score and handgrip strength, lateral pinch strength test, Purdue Pegboard placement time, and Purdue Pegboard collection time in patients with moderate FM (all p < 0.05). Conclusions. Our results show that hand function was decreased in patients with FM compared to healthy controls and decreasing hand function was influenced by FIQ score. As a result, the evaluation of hand function should be taken into consideration in the management of FM
Serum Levels of IL-17, IL-6, TNF-alpha and Disease Activity in Patients with Rheumatoid Arthritis
WOS: 000409185000008Objective the aim of this study was to evaluate serum levels of interleukin (IL)-17, IL-6, and tumor necrosis factor alpha (TNF-alpha) in RA patients and to assess the correlation of these cytokines with clinical and laboratory parameters. Materials and Methods 48 patients with RA and 35 healthy volunteers were enrolled in the study. Disease activity was determined by disease activity score (DAS28) in patients with RA. Patients with RA were categorized as mild (DAS28 0.05). Serum IL-6 levels were significantly elevated in RA patients compared with controls (P < 0.001). the increasing trend in mean serum IL-6 levels across group with mild, moderate, and severe disease activity was significant (P < 0.001, respectively). in RA patients, serum IL-6 concentrations were significantly correlated with ESR, CRP, DAS28, and VAS (r = 0.371, P = 0.009; r = 0.519, P < 0.001; r = 0.536, P < 0.001; r = 0.539, P < 0.001, respectively). Also, Serum IL-17 concentrations demonstrated significant correlations with ESR, CRP, but not DAS28 (r = 0.349, P = 0.015; r = 0.299, P = 0.039; r = 0.274, P = 0.060, respectively). Serum TNF-alpha showed no significant correlation with disease activity indices. Conclusions This study showed that patients with RA had significantly increased cytokine level for IL-6, but not IL-17 and TNF-alpha and high level of serum IL-6 cytokine was associated with disease activity. However, further follow-up studies involving large samples are required to clarify precise role of these cytokines in disease development and progress
Subtelomeric fish findings in Turkish patients with idiopathic mental retardation
PMID = 2434113
Lomber omurga dejenerati?f deği?şi?kli?kleri? olan hastalarda röntgen bulgulari i?le beden ki?tle i?ndeksi? (bki?) arasindaki? i?li?şki?; stereoloji?k bi?r ön çalişma
Objective: To evaluate the association between radiographic features (osteophytes, disc space narrowing) in patients with lumbar spine degenerative changes and body mass index (BMI), with quantitative methods. Material and Method: One-hundred and three women with lumbar spine degenerative changes who had lower back pain were included in the study. Patients were divided into two groups according to their BMI. Pain and functional status of patients were evaluated using visual analog scale (VAS) and Roland Morris Questionnaire (RMQ), respectively. The size of osteophytes and disc space narrowing were calculated on lateral roentgenogram of the lumbar vertebrae by using computer based stereological methods. Results: No significant correlation was detected between the BMI and radiological findings. But, there was a positive correlation between the osteophyte surface area and RMQ, and VAS and RMQ (p<0.05). Conclusion: No significant correlation was detected between the BMI and radiographic findings in lumbar spine degenerative changes. To our knowledge, this is the first study quantitatively assessing the association between radiographic findings and BMI in lumbar spine degenerative changes
Carbonic anhydrase I and II autoantibodies in Behcet's disease
Demir, Selim/0000-0002-1863-6280;WOS: 000398616200004PubMed: 28198796Background: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. the goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: the CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: the CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of B
WOMEN WITH PSORIATIC ARTHRITIS WHO ARE HOMEMAKERS OR OFFICE WORKERS DECLARE SIMILAR DIFFICULTIES DURING WORKING
Glutathione S-Transferase M1 and T1 Gene Polymorphisms are not Associated with Increased Risk of Gestational Diabetes Mellitus Development
Ultrasonographic evaluation of femoral cartilage thickness in patients with psoriatic arthritis
PMID = 2696681