5 research outputs found
Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids
Acetazolamide (ACZ) has been combined via liquid-assisted
grinding
in water with a library of cocrystal formers derived from benzoic
and nicotinic acid, which provided novel cocrystals with 2-hydroxybenzamide,
2-aminobenzamide, picolinamide, and 2,3-dihydroxybenzoic acid. The
cocrystalline phases were identified first by XRPD analysis and then
structurally characterized by IR spectroscopy and single-crystal X-ray
diffraction analysis. These cocrystals and the previously reported
cocrystalline phases obtained from 4-hydroxybenzoic acid and nicotinamide
constitute a series of six cocrystals of varied stoichiometric ratios
(3:1, 2:1, 1:1, and 1:2), which allowed for a profound analysis of
the structural and chemical factors that govern their formation. The
structural analysis has shown that the ACZ molecules participate in
the dominant hydrogen-bonding patterns within the crystal structures:
three cocrystal structures exhibit extended supramolecular aggregates
of ACZ having channels, pores, or semispherical voids, in which the
cocrystal formers are included as guest molecules, and can, therefore,
be described as inclusion or clathrate complexes. One cocrystal can
be considered as a pillared or intercalation compound, and the remaining
two cocrystals are true two-component 2D or 3D networks. In addition,
a variety of alternative preparative methods (liquid-assisted grinding,
neat grinding, reaction crystallization, solution-mediated phase transformation,
and solution crystallization) have been employed, showing that four
of the six cocrystals required the presence of water for successful
cocrystal formation
Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids
Acetazolamide (ACZ) has been combined via liquid-assisted
grinding
in water with a library of cocrystal formers derived from benzoic
and nicotinic acid, which provided novel cocrystals with 2-hydroxybenzamide,
2-aminobenzamide, picolinamide, and 2,3-dihydroxybenzoic acid. The
cocrystalline phases were identified first by XRPD analysis and then
structurally characterized by IR spectroscopy and single-crystal X-ray
diffraction analysis. These cocrystals and the previously reported
cocrystalline phases obtained from 4-hydroxybenzoic acid and nicotinamide
constitute a series of six cocrystals of varied stoichiometric ratios
(3:1, 2:1, 1:1, and 1:2), which allowed for a profound analysis of
the structural and chemical factors that govern their formation. The
structural analysis has shown that the ACZ molecules participate in
the dominant hydrogen-bonding patterns within the crystal structures:
three cocrystal structures exhibit extended supramolecular aggregates
of ACZ having channels, pores, or semispherical voids, in which the
cocrystal formers are included as guest molecules, and can, therefore,
be described as inclusion or clathrate complexes. One cocrystal can
be considered as a pillared or intercalation compound, and the remaining
two cocrystals are true two-component 2D or 3D networks. In addition,
a variety of alternative preparative methods (liquid-assisted grinding,
neat grinding, reaction crystallization, solution-mediated phase transformation,
and solution crystallization) have been employed, showing that four
of the six cocrystals required the presence of water for successful
cocrystal formation
Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids
Acetazolamide (ACZ) has been combined via liquid-assisted
grinding
in water with a library of cocrystal formers derived from benzoic
and nicotinic acid, which provided novel cocrystals with 2-hydroxybenzamide,
2-aminobenzamide, picolinamide, and 2,3-dihydroxybenzoic acid. The
cocrystalline phases were identified first by XRPD analysis and then
structurally characterized by IR spectroscopy and single-crystal X-ray
diffraction analysis. These cocrystals and the previously reported
cocrystalline phases obtained from 4-hydroxybenzoic acid and nicotinamide
constitute a series of six cocrystals of varied stoichiometric ratios
(3:1, 2:1, 1:1, and 1:2), which allowed for a profound analysis of
the structural and chemical factors that govern their formation. The
structural analysis has shown that the ACZ molecules participate in
the dominant hydrogen-bonding patterns within the crystal structures:
three cocrystal structures exhibit extended supramolecular aggregates
of ACZ having channels, pores, or semispherical voids, in which the
cocrystal formers are included as guest molecules, and can, therefore,
be described as inclusion or clathrate complexes. One cocrystal can
be considered as a pillared or intercalation compound, and the remaining
two cocrystals are true two-component 2D or 3D networks. In addition,
a variety of alternative preparative methods (liquid-assisted grinding,
neat grinding, reaction crystallization, solution-mediated phase transformation,
and solution crystallization) have been employed, showing that four
of the six cocrystals required the presence of water for successful
cocrystal formation
Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids
Acetazolamide (ACZ) has been combined via liquid-assisted
grinding
in water with a library of cocrystal formers derived from benzoic
and nicotinic acid, which provided novel cocrystals with 2-hydroxybenzamide,
2-aminobenzamide, picolinamide, and 2,3-dihydroxybenzoic acid. The
cocrystalline phases were identified first by XRPD analysis and then
structurally characterized by IR spectroscopy and single-crystal X-ray
diffraction analysis. These cocrystals and the previously reported
cocrystalline phases obtained from 4-hydroxybenzoic acid and nicotinamide
constitute a series of six cocrystals of varied stoichiometric ratios
(3:1, 2:1, 1:1, and 1:2), which allowed for a profound analysis of
the structural and chemical factors that govern their formation. The
structural analysis has shown that the ACZ molecules participate in
the dominant hydrogen-bonding patterns within the crystal structures:
three cocrystal structures exhibit extended supramolecular aggregates
of ACZ having channels, pores, or semispherical voids, in which the
cocrystal formers are included as guest molecules, and can, therefore,
be described as inclusion or clathrate complexes. One cocrystal can
be considered as a pillared or intercalation compound, and the remaining
two cocrystals are true two-component 2D or 3D networks. In addition,
a variety of alternative preparative methods (liquid-assisted grinding,
neat grinding, reaction crystallization, solution-mediated phase transformation,
and solution crystallization) have been employed, showing that four
of the six cocrystals required the presence of water for successful
cocrystal formation
Modification of the Supramolecular Hydrogen-Bonding Patterns of Acetazolamide in the Presence of Different Cocrystal Formers: 3:1, 2:1, 1:1, and 1:2 Cocrystals from Screening with the Structural Isomers of Hydroxybenzoic Acids, Aminobenzoic Acids, Hydroxybenzamides, Aminobenzamides, Nicotinic Acids, Nicotinamides, and 2,3-Dihydroxybenzoic Acids
Acetazolamide (ACZ) has been combined via liquid-assisted
grinding
in water with a library of cocrystal formers derived from benzoic
and nicotinic acid, which provided novel cocrystals with 2-hydroxybenzamide,
2-aminobenzamide, picolinamide, and 2,3-dihydroxybenzoic acid. The
cocrystalline phases were identified first by XRPD analysis and then
structurally characterized by IR spectroscopy and single-crystal X-ray
diffraction analysis. These cocrystals and the previously reported
cocrystalline phases obtained from 4-hydroxybenzoic acid and nicotinamide
constitute a series of six cocrystals of varied stoichiometric ratios
(3:1, 2:1, 1:1, and 1:2), which allowed for a profound analysis of
the structural and chemical factors that govern their formation. The
structural analysis has shown that the ACZ molecules participate in
the dominant hydrogen-bonding patterns within the crystal structures:
three cocrystal structures exhibit extended supramolecular aggregates
of ACZ having channels, pores, or semispherical voids, in which the
cocrystal formers are included as guest molecules, and can, therefore,
be described as inclusion or clathrate complexes. One cocrystal can
be considered as a pillared or intercalation compound, and the remaining
two cocrystals are true two-component 2D or 3D networks. In addition,
a variety of alternative preparative methods (liquid-assisted grinding,
neat grinding, reaction crystallization, solution-mediated phase transformation,
and solution crystallization) have been employed, showing that four
of the six cocrystals required the presence of water for successful
cocrystal formation