Age at diagnosis in FTD.

<p>(A) Age at diagnosis in FTD cases registered in SveDem 2008–2011. (B) The proportion of FTD cases in each age group in the total FTD cohort (blue bars), compared to those cases diagnosed in specialist centres where investigations included cognitive testing and structural or functional imaging (red bars) and cases that had performed lumbar puncture with CSF analysis (green bars).</p

Age-related incidence in FTD and AD.

<p>The figures show the incidence of FTD (A; blue bars) and AD (B; red bars) in relation to age (years). Values for incidence are given as cases per 100 000 person-years in each 5 year age cohort.</p

Diagnosis, age at diagnosis and gender distribution in SveDem 2008-11.

<p>Data are n (%) for diagnoses, mean age (range) and the female (F)/male (M) distribution percentage (p-value). Statistical differences in gender distribution was calculated by a binomial test, see Methods. AD  =  Alzheimer's disease, VaD  =  Vascular dementia, FTD  =  Frontotemporal dementia, DLB  =  Dementia with Lewy bodies, PDD  =  Parkinson disease dementia, Other  =  Dementia of other causes, Dementia NS  =  Dementia not specified.</p

Family history in FTD and AD.

<p>The data shown in (A) represents the response to questions on the presence of dementia in first-degree and second-degree relatives of patients diagnosed with AD (blue bars) and FTD (red bars). In (B), the responses in FTD cases are divided into age cohorts: 39–64, 65–80, and 81–96 years. For classification purposes, the responses were divided into three categories: Positive family history (Yes), negative family history (No/None known) and Not known (reserved for when questions about family history have not been asked alternatively no response registered).</p

SUPERSMART: Self Updating Platform for Estimating Rates of Speciation and Migration, Ages and Relationships of Taxa. Poster

<p>Poster discribing the "SUPERSMART" (Self Updating Platform for Estimating Rates of Speciation and Migration, Ages and Relationships of Taxa) pipeline. </p

Additional file 1: Figure S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Additional neuropathology. Additional photomicrographs from three family members. Individuals, immunohistochemistry, and enlargement as indicated. (TIF 11179 kb

Additional file 3: Table S2. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Individual data from previous publications (systematic review). Numbers indicate disease duration at first reported or observed symptom. Data in parentheses are successive or vaguely specified development or data unspecifically described. *Symptoms reported by patient or relative. #Unreliable data owing to possible pharmacological cause (neuroleptics). §Data too imprecisely reported to be included in calculations. AD Alzheimer’s disease, MCI Mild cognitive impairment, Dementia NOS Dementia not otherwise specified, CSF Cerebrospinal fluid, Aβ 42 Amyloid-β 1–42, APOE Apolipoprotein E, ADL Activities of daily living. (PDF 161 kb

Additional file 4: Table S3. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Cerebrospinal fluid examinations. Numbers in parentheses indicate disease duration when cerebrospinal fluid was retrieved. Upward filled triangles = value above laboratory’s reference value for healthy individuals; downward filled triangles = value below laboratory’s reference value for healthy individuals. aCompared with healthy control subjects (157 ± 65 pg/ml, n = 24) and patients with AD (555 ± 248 pg/ml, n = 31). bCompared with healthy control subjects (29 ± 10 pg/ml, n = 21) and patients with AD (86 ± 39 pg/ml, n = 31). N/A Not assessed. (PDF 304 kb

Additional file 2: Table S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

MAPT haplotype determination based on exome sequencing data. Individuals, residues, and haplotype as indicated. Note that the proband, individual III-2, had Alzheimer’s disease and was excluded from the study. (PDF 181 kb

Additional file 1: Figure S1. of Slowly progressive dementia caused by MAPT R406W mutations: longitudinal report on a new kindred and systematic review

Additional neuropathology. Additional photomicrographs from three family members. Individuals, immunohistochemistry, and enlargement as indicated. (TIF 11179 kb