Cold agglutinins in peripheral blood with atypical cells with an owl-eye appearance in bone trephine

Autoimmune hemolytic anemia (AIHA) is a form of hemolytic anemia in which red cells lysis occurs due to presence of an autoantibody. Association of AIHA is well known with lymphoproliferative disorders, especially with non-Hodgkin\u27s lymphoma. However, AIHA in association with Hodgkin\u27s lymphoma is seen occasionally. Of the AIHA associated with Hodgkin\u27s lymphoma, most are of warm type or mixed type. Cold AIHA, as seen in our case, is very rare in Hodgkin\u27s lymphoma

The Impact of Dispositional Optimism and Self-determination on Wellbeing of Job Seeker Young Adults

The present study aimed to find out that 1) dispositional optimism and self-determination are positively related to well-being in job seekers young adults, and 2) to find out the predicting role of dispositional optimism and self-determination in determining the well-being of job seekers. The study was based on a correlational research design. A purposive sample of 192 job seekers young adults aged 19 to 27 years (M =22, SD=1.25) was taken as a sample. The sample consisted of 91 men and 101 women from four different universities in Lahore. Urdu versions of the Life orientation test-revised (Scheier et al., 1985), Self-determination scale (Deci & Ryan, 2000), Mental health continuum short-form (Keyes & Ryff, 1998) and self-constructed demographic information sheet were used for assessment. The results showed that dispositional optimism, self-determination, and well-being are positively related to young job seekers. Further, dispositional optimism and self-determination were found as positive predictors of well-being in job-seeking young adults. Further, the results also indicated that men have higher social well-being as compared to women. The limitations and suggestions are also discussed

Prevalence and severity of urinary incontinence among females after normal vaginal delivery

Background: Urinary Incontinence is the most common disorder associated with women after vaginal delivery due to the weakening of pelvic floor muscles. More than 50% of females experience urinary incontinence. It is defined as the involuntary leakage of urine. The condition is common not only in older women but also in young nulliparous women. Objective: The key objective of the study was to determine the prevalence and severity of Urinary Incontinence after normal vaginal delivery. Method: The study was Cross-sectional and there were 160 participants in the study. The study was conducted at the Physical Therapy department and Gynaecology Ward of Fauji Foundation and Geo hospital Lahore. The data was collected from women who had delivered between the ages of 20-40 years. The data collection was done by using Incontinence Severity Index that was used as primary outcome measure. Results: A total of 160 responses were received, based on inclusion and exclusion criteria. Among respondents, females in the age group of 20-25 had a rate of urinary incontinence with 31.3 percent. Results showed that females in the age group of 25-30 had high BMI and had a high rate of urinary incontinence with the range of 61.3 percent. As result, there was a positive correlation of urinary incontinence between age and score that ranged from 0.185. There was a positive correlation of urinary incontinence between the score and BMI that ranged between 0.174. Conclusion: This analysis revealed that there was a high prevalence rate of urinary incontinence among females after delivery that had a correlation with age

An electron-deficient triosmium cluster containing the thianthrene ligand: Synthesis, structure and reactivity of [Os₃(CO)₉(μ3-η2-C₁₂H₇S₂)(μ-H)]

Reaction of [Os₃(CO)₁₀(CH₃CN)₂] with thianthrene at 80 °C leads to the nonacarbonyl dihydride compound [Os₃(CO)₉(μ-3,4-η²-C₁₂H₆S₂)(μ-H)₂] (1) and the 46-electron monohydride compound [Os₃(CO)₉(μ₃-η²-C₁₂H₇S₂)(μ-H)] (2). Compound 2 reacts reversibly with CO to give the CO adduct [Os₃(CO)₁₀(μ-η²-C₁₂H₇S₂)(μ-H)] (3) whereas with PPh₃ it gives the addition product [Os₃(CO)₉)(PPh₃)(μ-η²-C₁₂H₇S₂)(μ-H)] (4) as well as the substitution product 1,2-[Os₃(CO)₁₀ ((PPh₃)₂] (5) Compound 2 represents a unique example of an electron-deficient triosmium cluster in which the thianthrene ring is bound to cluster by coordination of the sulfur lone pair and a three-center-two-electron bond with the C(2) carbon which bridges the same edge of the triangle as the hydride. Electrochemical and DFT studies which elucidate the electronic properties of 2 are reported

Maternal risk factors and short term outcome of prematurity: A descriptive study at a secondary care hospital

Background: Approximately 15 million babies are born premature (before 37 weeks of gestation) and 1 million babies die due to prematurity complications every year. Less is known about risk factors of prematurity in middle and low-income countries. The prevalence of prematurity ranges from 5% - 18%. Objective: To determine the prevalence of premature births and to assess the rate of survival, along with the morbidity, among preterm newborns. Furthermore, to document our experience with different gestational age groups of preterm births; and to analyze the association among these strata and their clinical outcomes. Study Design: A descriptive study. Place and Duration of Study: The Aga Khan Maternal and Childcare Centre Hyderabad, Pakistan, from 1st January 2017 to 31st December 2018. Methodology: All pregnant women registered at the obstetric clinic before 24 weeks of gestation having at least three subsequent visits at the same clinic were included in the study. The women who were lost to follow up before completing three visits were excluded from the study. All un-booked women were also excluded from the study. Demographic profile was recorded including maternal age, parity, no of visits at the clinic, gestational age, mode of delivery, birth weight and pregnancy outcome. Newborns were subsequently followed at nursery or well-baby till discharge. Further subgroups were made for gestational age to assess the frequency of various morbidities in each group. Results: One thousand and ninety-one (1091) women were included in the study period that fulfilled the inclusion criteria. Two pregnancies were terminated before 24 weeks due to major congenital malformations. The prevalence of prematurity was recorded as 13.4% (146/1089). Perinatal mortality rate (no of stillbirths plus the number of early neonatal death/1000 live birth) was 17 (15.6/1000 live births) out of them, 12 were still births and 5 were early neonatal death. Out of the total preterm babies born, 59.5% (87/146) were admitted to the nursery. In the study group (2%/3146) were extreme preterm, while 7.5% were severe preterm (11/146). Moderate preterm was 11.6% (17/146) and the majority were late preterm accounting for 78.7% (115/146). Though the incidence of birth asphyxia were noted more in late preterm babies i.e. 10 as the number of these babies are also high in our study but the overall percentage was low (8.7%) as compared with the babies of extreme prematurity (100%) and moderate late prematurity (23.5%) respectively. In pregnancy outcome, 12 were still births in which six (50%) were in the late preterm group. Total of 17 newborns suffered from birth asphyxia in which ten newborns (58.8%) were in late preterm group. Overall, it was noted that the decreasing gestational age was directly correlated to morbidity and mortality. Conclusion: Among the different strata, the late preterm group has been observed to be associated with greater morbidity and mortality. Prior awareness of the morbidities associated with late preterm babies is helpful for the health care providers to anticipate and manage potential complications in preterm infants

Uptake of provider-initiated HIV testing and counseling among women attending an urban sexually transmitted disease clinic in South Africa . . .

This study assessed the uptake of provider-initiated HIV testing and counseling (PITC) among women attending an urban sexually transmitted diseases (STD) clinic in South Africa. From July 2005 to June 2006, women were offered HIV testing following group information and education on HIV and STDs in the clinic waiting area. Of those who were provided with education, information, and offered HIV testing, uptake was 43.5% (2439/5612). The overall HIV prevalence among those tested was 56.5% and the prevalence of acute HIV infection was 1.2%. Of the 56.5% (3173/5612) refusing to test, the reasons for not testing were having already been tested for HIV (61.8%), being afraid to test or felt unready to test (32.5%), the need to consult with partner (0.9%), and refusing with no explanation (4.8%). In settings where high-risk patients await health care services, such as an STD clinic, failure to implement PITC is a missed opportunity for patients to benefit from counseling, prevention, early diagnosis, and referral into care and treatment for HIV infection

Outcome of Percutaneous Ultrasound Guided Aspiration versus Open Surgical Drainage of Psoas Muscle Abscess

Objective: To compare the outcome of percutaneous ultrasound guided aspiration V/S open surgical drainage for psoas muscle abscess. Methodology: This comparative study was conducted in department of general surgery at Liaquat medical university hospital Hyderabad/Jamshoro, from June 2017 to November 2017. Diagnosed Patients of psoas muscle abscess size more than 5cm, between 18 to 60 years of age and either of gender were included. Patients were randomly divided into two groups, A and B by odd and even method, patients in group A abscess was aspirated by percutaneous ultrasound guided aspiration and patients in group B was underwent open surgical drainage, all the data were entered in the pre designed performa and analyzed into SPSS V:16.0 Results: A total of 58 patients of Psoas muscle abscess were selected, the mean age of study subjects of group A was 38.5+10.5 and group B was 36.5+12.7 (p-673). Early post-operative pain relief was assessed among patients of group A as compared to group B. As per outcome resolution of abscess cavity was significantly high among patients of group B (p-0.004), while post-operative Hospital stay was significantly lower in group A (p-0.002). Conclusion: Both techniques has their own benefits like percutaneous aspiration has shorter duration of hospital stay while in complete resolution of abscess cavity was found in open surgical drainage group of patients

HIV infection and AIDS in Sub-Saharan Africa : current status, challenges and opportunities.

CAPRISA, 2016.Abstract available in PDF file