A Strained Disilane-Promoted Carboxylation of Organic Halides with CO₂ under Transition-Metal-Free Conditions

By using a strained four-membered ring disilane (3,4-benzo-1,1,2,2-tetra­ethyldisila­cyclobutene) and CsF, a wide range of aryl, alkenyl, alkynyl, benzyl, allyl, and alkyl halides was successfully carboxylated under an ambient CO₂ atmosphere (CO₂ balloon) at room temperature within 2 h. In this carboxylation, a highly reactive silyl anion, which is generated from the disilane and CsF, is a key to facilitating the formation of a carbanion equivalent. The resulting anionic species can be trapped with CO₂ to produce carboxylic acids with high efficiency

Additional file 1: of Factors that associated with TB patient admission rate and TB inpatient service cost: a cross-sectional study in China

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Additional file 1: of Non-medical financial burden in tuberculosis care: a cross-sectional survey in rural China

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Additional file 1: of The impact of the new cooperative medical scheme on financial burden of tuberculosis patients: evidence from six counties in China

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Additional file 1: of Use of anti-tuberculosis drugs among newly diagnosed pulmonary tuberculosis inpatients in China: a retrospective study

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Health and lifestyle characteristics at entry to analysis (n = 1201).

<p>*Metabolic Equivalent hours.</p><p>Health and lifestyle characteristics at entry to analysis (n = 1201).</p

Association between quintiles of post-diagnosis diet score (Hazard ratio and 95% CI) and colorectal cancer mortality.

<p>*Adjusted for age, physical activity, BMI, weight change, cancer grade, chemotherapy, smoking status, energy intake, colon or rectal cancer, stage of disease, and date of colorectal cancer diagnosis.</p><p>Association between quintiles of post-diagnosis diet score (Hazard ratio and 95% CI) and colorectal cancer mortality.</p

Multivariable^* hazard ratio (95% CI) of AHEI-2010 components (per serving per day unless otherwise specified) for mortality in NHS (1986–2010).

<p>*Adjusted for age, physical activity, BMI, weight change, cancer grade, chemotherapy, smoking status, energy intake, colon or rectal cancer, stage of disease, date of colorectal cancer diagnosis.</p><p>**After additional adjustment for an AHEI-2010 score without the specific component, RR of overall mortality for alcohol, sweetened beverages + juices remained unchanged and significant, but for nuts and CRC mortality was slightly attenuated and no longer significant (RR = 0.71, 95% CI = 0.50 = 1.01).</p><p>Multivariable^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0115377#nt104" target="_blank">*</a>} hazard ratio (95% CI) of AHEI-2010 components (per serving per day unless otherwise specified) for mortality in NHS (1986–2010).</p

Association between quintiles of post-diagnosis diet score (Hazard ratio and 95% CI) and overall mortality.

<p>*Adjusted for age, physical activity, BMI, weight change, cancer grade, chemotherapy, smoking status, energy intake, colon or rectal cancer, stage of disease, and date of colorectal cancer diagnosis.</p><p>Association between quintiles of post-diagnosis diet score (Hazard ratio and 95% CI) and overall mortality.</p

Kaplan-Meier survival curve for disease-free survival in colorectal (A), colon (B) and rectal (C) cancer patients staged I to III by diabetes mellitus status.

<p>Kaplan-Meier survival curve for disease-free survival in colorectal (A), colon (B) and rectal (C) cancer patients staged I to III by diabetes mellitus status.</p