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Evaluation of Indian medicinal plants used traditionally for the treatment of Malaria. Phytochemical investigation of Alangium lamarkii and Tarenna zeylanica for antiplasmodial and cytotoxic properties.
Association of Commonwealth Universities. Commonwealth Scholarship Commission. United Kingdom
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Complete NMR assignments of tubulosine
NoThis article reports the structural elucidation of the Alangium alkaloid, tubulosine (1) on the basis of systematic 2D-NMR analyses (DEPT, COSY, TOCSY, NOESY, ROESY, HMQC and HMBC). The data obtained allowed the unambiguous assignment of all proton and carbon signals in 1 for the first time
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Evaluation of Alangium lamarckii bark for antiplasmodial and cytotoxic constituents and isolation of a novel tubulosine analogue
NoAlangium lamarkii is traditionally used in India for the treatment of malaria. Partial activity guided-fractionation of the basic chloroform fraction of the methanolic extract of the bark led to the isolation of a novel tubulosine analogue, 10-demethyl-9ËŠ-N-methyltubulosine (1), for which the trivial name tubulosatine is suggested. In addition, the known A. lamarkii constituents, tubulosine (2), cephaeline and emetine were isolated as potent antiplasmodial and cytotoxic constituents, but 1 was up to 1000-fold less potent than the former alkaloids against both malaria parasites and human cancer cell lines. The compounds were active against both chloroquine-sensitive and chloroquine-resistant malaria parasites, but no selective toxicity was observed towards malaria parasites compared with cancer cells with any of the alkaloids. Further work to explore the basis for the relatively weak biological activities of 1 would be worthwhile. Betulinic acid, stigmasterol and its 3-O-glucoside were isolated from the neutral chloroform fraction of the methanolic extract.ACU, UK (Commonwealth Scholarship, Ref. No.: INCS-2004-144)