The fatherhood of God from Origen to Athanasius

Reviewed Book: Widdicombe, Peter. The fatherhood of God from Origen to Athanasius. Oxford: Clarendon Pr; [S.l.]: Oxford Univ Pr, 1994. Oxford theological monographs

An Ontological Basis for Design Methods

This paper presents a view of design methods as process artefacts that can be represented using the function-behaviour-structure (FBS) ontology. This view allows identifying five fundamental approaches to methods: black-box, procedural, artefact-centric, formal and managerial approaches. They all describe method structure but emphasise different aspects of it. Capturing these differences addresses common terminological confusions relating to methods. The paper provides an overview of the use of the fundamental method approaches for different purposes in designing. In addition, the FBS ontology is used for developing a notion of prescriptiveness of design methods as an aggregate construct defined along four dimensions: certainty, granularity, flexibility and authority. The work presented in this paper provides an ontological basis for describing, understanding and managing design methods throughout their life cycle. Keywords: Design Methods; Function-Behaviour-Structure (FBS) Ontology; Prescriptive Design Knowledge</p

What Benefits Can Subject-Oriented Process Modeling Bring to the Design of Big Data Applications?

Big data applications usually entail the development of complex IT-systems that collect, combine, analyze, communicate and use large amounts of data from different sources. The interactions between system components can be difficult to understand and describe, due to their large number, heterogeneity, and concurrency (e.g. continuous and discrete processes, or different technologies, may interact). In addition, system changes may occur as a result of new requirements or constraints during the lifecycle of any data processing system. In the system design process, multiple stakeholders need to collaborate and align their individual views of the system, e.g. sensor specialists, hardware designers, IT integrators, operational departments, etc. This alone can be a challenge because different domain experts often have different concerns and use different terminologies and abstraction concepts. Only few of these experts have a system design or modeling background, which can make the elicitation and capture of system knowledge difficult and error-prone. Our research is concerned with the subject-oriented approach to process modeling (S-BPM) (Fleischmann et al. 2012). We argue that it can address the various design challenges arising from the high complexity of big data systems. It has four foundational characteristics that distinguish it from other approaches (Kannengiesser 2017), Figure 1: 1. notational simplicity, 2. widely-shared, intuitive semantics, 3. encapsulation and 4. seamless integration

Rationale in Semi-Structured Processes

Abstract. This paper argues that an explicit account of rationale is essential for the effective management and evolution of semi-structured processes. Our approach is based on a view of semi-structured process models as unfinished products whose design is implicitly completed through their execution by process model users. The resulting refinements and modifications of the process models are instances of user-driven design innovation. Our framework shows how rationale can explain a user’s individual execution decisions, as a basis for process modelers to improve the original process specifications. We propose and illustrate a modeling approach using the FBS ontology

Signal-induced ubiquitination of p57Kip2 is independent of the C-terminal consensus Cdk phosphorylation site

AbstractThe cyclin-dependent kinase inhibitor p57Kip2 is required for normal mouse embryonic development. p57Kip2 consists of four structurally distinct domains in which the conserved C-terminal nuclear targeting domain contains a putative Cdk phosphorylation site (Thr342) that shares a great similitude in the adjacent sequences with p27Kip1 but not with p21Cip1. Phosphorylation on Thr187 has been shown to promote degradation of p27Kip1. Although there is sequence homology between the C-terminal part of p27Kip1 and p57Kip2, we show that the ubiquitination and degradation of p57Kip2 are independent of Thr342. In contrast a destabilizing element located in the N-terminal is implicated in p57Kip2 destabilization