4 research outputs found
Evaluation of immunostimulatory activity of Chyawanprash using <i style="mso-bidi-font-style:normal">in vitro </i>assays<i style="mso-bidi-font-style:normal"><span style="font-size:11.0pt; mso-bidi-font-size:10.0pt" lang="EN-GB"></span></i>
158-163Chyawanprash is an ayurvedic formulation
used in Indian traditional medicinal system for its beneficial effect on human
health. We investigated the immunostimulatory effects of Chyawanprash (CHY)
using in vitro assays evaluating the
secretion of cytokines such as Tumor Necrosis Factor-alpha (TNF-α),
Interleukin-1beta (IL-1β) and Macrophage Inflammatory Protein-1-alpha (MIP-1-α)
from murine bone marrow derived Dendritic Cells (DC) which play pivotal role in
immunostimulation. The effects of CHY on phagocytosis in murine macrophages
(RAW264.7) and Natural Killer (NK) cell activity were also investigated. At
non-cytotoxic concentrations (20–500 µg/ml), CHY enhanced the secretion of all
the three cytokines from DC. CHY also stimulated both, macrophage (RAW264.7) as
well as NK cell activity, in vitro.
In conclusion, the data substantiates the immunoprotective role of CHY at
cellular level mediated by immunostimulation in key immune cells viz. dendritic
Cells, macrophages and NK cells