sj-tif-4-tag-10.1177_17562848231165129 – Supplemental material for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions

Supplemental material, sj-tif-4-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology</p

sj-tif-2-tag-10.1177_17562848231165129 – Supplemental material for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions

Supplemental material, sj-tif-2-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology</p

sj-docx-1-tag-10.1177_17562848231165129 – Supplemental material for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions

Supplemental material, sj-docx-1-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology</p

sj-tif-3-tag-10.1177_17562848231165129 – Supplemental material for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions

Supplemental material, sj-tif-3-tag-10.1177_17562848231165129 for Neutrophil-to-lymphocyte ratio for predicting postoperative recurrence in Crohn’s disease patients with isolated anastomotic lesions by Rirong Chen, Chao Li, Kang Chao, Yizhe Tie, Jieqi Zheng, Huili Guo, Zhirong Zeng, Li Li, Minhu Chen and Shenghong Zhang in Therapeutic Advances in Gastroenterology</p

Additional file 7: Figure S5. of Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease

IL23 reduced the expression of CLDN8 in a time-dependent manner in NCM460 and Caco-2 cells. (EPS 758 kb

Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China

Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD risk. We used quantitative real-time polymerase chain reaction to measure the expression levels of inflammatory factors. The levels of protein expression in the colorectum were determined using Western blotting (WB). Compared to the lowest quartile of serum MC-LR levels, the adjusted odds ratios and 95% confidence intervals (CI) for the highest quartiles of serum MC-LR levels were 5.51 (2.70, 11.21). The RCS was shown the association between serum MC-LR levels and IBD risk was nonlinear (Pnonlinear < 0.001). In the animal experiments, MC-LR resulted in colorectal injury via the PI3K/AKT signaling pathway. Our study provides the evidence that serum MC-LR exposure is significantly associated with the risk of IBD in China. Animal study results indicate that MC-LR probably causes IBD via the PI3K/AKT signaling pathway

Additional file 1: Figure S1. of Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5+ B regulatory cells

Identification of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs). HUC-MSCs were identified according to the International Society for Cellular Therapy statement. The cells were adherent to plastic (A), differentiated to adipocytes (B) and osteoblasts (C) in vitro, and expressed specific surface antigens (positive for CD73, CD90, and CD105; negative for CD45, CD34, CD14, CD19, and HLA-DR) (D). (TIF 6040 kb