On the histogenesis of cardiac myxoma

Objective - to investigate the morphological and phenotypic features of cardiac myxoma (CM), to discuss argumentative issues on the sources of its growth. Subjects and methods. The investigation included 176 sporadic and familial myxomas originating from different cardiac chambers (96% from the atria). The histological, ultrastructural, and immunohistochemical features of the cells and vessels of this tumor were studied. Results. The morphological and phenotypic features of the embryonic endothelium resembling the cells of the primary cardiovascular network were found in the cells and vessels of CM. No signs of other mesenchymal derivatives were detected. Discussion. The authors anticipate that there is focal cessation of maturation of the embryonic endocardial endothelium and its persistence - hamartia. Postnatal proliferation of embryonic hamartia forms the tumor hamartoma. Differentiated cells may retain the phenotypic (but not morphological) features of closely related cells that have a common precursor. Conclusion. The results of the study have allowed the authors to consider CM to be hamartoma, a monohistioid benign embryonic endocardial endothelioma. Our findings do not exclude the possibility of developing CM from pluripotent mesenchymal cells. © 2018 Media Sphera Publishing Group. All rights reserved

On the histogenesis of cardiac myxoma

Objective - to investigate the morphological and phenotypic features of cardiac myxoma (CM), to discuss argumentative issues on the sources of its growth. Subjects and methods. The investigation included 176 sporadic and familial myxomas originating from different cardiac chambers (96% from the atria). The histological, ultrastructural, and immunohistochemical features of the cells and vessels of this tumor were studied. Results. The morphological and phenotypic features of the embryonic endothelium resembling the cells of the primary cardiovascular network were found in the cells and vessels of CM. No signs of other mesenchymal derivatives were detected. Discussion. The authors anticipate that there is focal cessation of maturation of the embryonic endocardial endothelium and its persistence - hamartia. Postnatal proliferation of embryonic hamartia forms the tumor hamartoma. Differentiated cells may retain the phenotypic (but not morphological) features of closely related cells that have a common precursor. Conclusion. The results of the study have allowed the authors to consider CM to be hamartoma, a monohistioid benign embryonic endocardial endothelioma. Our findings do not exclude the possibility of developing CM from pluripotent mesenchymal cells. © 2018 Media Sphera Publishing Group. All rights reserved

A case of Lambl’s excrescences of the mitral valve concurrent with myocardial infarction

Lambl’s excrescences are a rare disease that is characterized by a lesion of the heart valves as filamentous growths on their surface mainly along the coaptation lines and that is mostly asymptomatic. Due to traumatic injuries during heart contractions, fibrin masses can be deposited on the surface of the growths, contributing to thromboembolic events or infection. The paper provides the data available in the literature and demonstrates a postmortem observation of Lambl’s excrescences on the ventricular surface of the mitral valve concurrent with myocardial infarction. © K.A. ROGOV3, L.V. KAKTURSKY, M.I. TARAKIN, V.M. GORLUSHKIN

Наблюдение экскресценций Ламбля митрального клапана в сочетании с инфарктом миокарда

Lambl’s excrescences are a rare disease that is characterized by a lesion of the heart valves as filamentous growths on their surface mainly along the coaptation lines and that is mostly asymptomatic. Due to traumatic injuries during heart contractions, fibrin masses can be deposited on the surface of the growths, contributing to thromboembolic events or infection. The paper provides the data available in the literature and demonstrates a postmortem observation of Lambl’s excrescences on the ventricular surface of the mitral valve concurrent with myocardial infarction.Экскресценции Ламбля - редкая патология, характеризующаяся поражением клапанов сердца в виде нитевидных разрастаний на их поверхности, преимущественно по линиям смыкания, и протекающая в основном бессимптомно. В связи с травматическими повреждениями при сердечных сокращениях на поверхности разрастаний могут откладываться массы фибрина, способствующие образованию тромбоэмболических осложнений или инфицированию. Приведены данные литературы и демонстрируется секционное наблюдение экскресценций Ламбля на желудочковой поверхности митрального клапана в сочетании с инфарктом миокарда