Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMDL, for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMDL were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMDL values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.This work was supported by JSPS KAKENHI Grant Number 16K21076

The Effect of Water Vapor on Tropical Cyclone Genesis: A Numerical Experiment of a Non-Developing Disturbance Observed in PALAU2010

The environmental conditions for tropical cyclone genesis are examined by numerical experiment. We focus on the case of a non-developing disturbance showed features for tropical cyclone genesis in the Pacific Area Long-term Atmospheric observation for Understanding climate change in 2010 (PALAU2010) observation campaign over the western North Pacific. We clarify the importance of the presence of abundant moisture around the disturbance for continuous convection and demonstrate that the collocation of a mid-level vortex and a low-level vortex, i.e., the persistence of an upright structure of vortices, is important in tropical cyclone genesis. We conduct two numerical experiments using the Weather Research and Forecasting Model Advanced Research WRF model in double nested domains with a horizontal grid space of 27 km and 9 km for the outer domain and the inner domain, respectively. The first experiment is based on reanalysis data (a control experiment) and the second includes increased water vapor content over the northwestern dry area of the disturbance. In the control experiment, the disturbance did not develop into a tropical cyclone in spite of the existence of the mid-level and low-level vortices. In contrast, the sensitivity experiment shows that a tropical cyclone was formed from the disturbance with increased water vapor content. The presence of persistent upright vortices was supported by continuous convection until the genesis of the tropical cyclone

Decomposition of the large-scale atmospheric state driving downscaling: a perspective on dynamical downscaling for regional climate study

Abstract In this study, we provide a perspective on dynamical downscaling that includes a comprehensive view of multiple downscaling methods and a strategy for achieving better assessment of future regional climates. A regional climate simulation is generally driven by a large-scale atmospheric state obtained by a global climate simulation. We conceptualize the large-scale state based on reconstruction by combining decomposed components of the states, such as climatology and perturbation, in different global simulations. The conceptualization provides a comprehensive view of the downscaling methods of previous studies. We propose a strategy for downscaling regional climate studies based on the concept of covering a wider range of possibilities of large-scale states to account for the uncertainty in global future predictions due to model errors. Furthermore, it also extracts the individual influences of the decomposed components on regional climate change, resulting in better understanding of the cause of the change. We demonstrate a downscaling experiment to highlight the importance of the simultaneous consideration of the individual influences of climatology and perturbation