Inferring Strings from Position Heaps in Linear Time

Position heaps are index structures of text strings used for the string matching problem. They are rooted trees whose edges and nodes are labeled and numbered, respectively. This paper is concerned with variants of the inverse problem of position heap construction and gives linear-time algorithms for those problems. The basic problem is to restore a text string from a rooted tree with labeled edges and numbered nodes. In the variant problems, the input trees may miss edge labels or node numbers which we must restore as well.Comment: 10 pages, 5 figure

Implementing a Professional Learning Community(PLC) at Special Needs Schools Focus on the Relationships among the PLC, the Curriculum Management and the Realization of passing on expertise

全国の特別支援学校〔聴覚障害部門〕を対象に，カリキュラム・マネジメントの実施や「専門職の学習共同体」の醸成，専門性の継承・向上の実現に関する質問紙調査を行った。収集したデータをもとに相互の関係性を分析した結果，「専門職の学習共同体」を醸成している学校においては専門性を継承・向上している実感が高いことが明らかとなった。また，実施するカリキュラム・マネジメントの質（内容）として「カリキュラムの『見える化』と共有の場づくり」，「カリキュラム開発のための協働の場づくり」等のカリキュラムを基軸に教職員間のつながりを深める取組を行っている学校においては，「専門職の学習共同体」の構成因子のうち「学校内の信頼関係」，「目標の共有」，「学校内外の協働」が醸成されていることが示された。このことから「専門職の学習共同体」を効果的に醸成していくためには，質の高いカリキュラム・マネジメントを実施する必要性が示唆された

Extracting Innovative Buyers by Scoring Using Innovator Theory

For companies that want to sell a high volume of products, it is important to identify innovative buyers to help with product marketing efforts. The purpose of this paper is to construct a model extracting whether users are innovative buyers or not from their purchase histories at physical stores and from access logs from an online-to-offline (O2O) site. Innovative buyers are users who influence other users' product purchases, also known in innovator theory as innovators and early adopters. They purchase products quickly, visiting physical stores such as supermarkets and convenience stores. In other words, innovative buyers are known to have high cosmopolite natures. In extracting innovative buyers, we estimated the speed of user product purchases and their cosmopolite natures. This estimation index can also be referred to as innovator scores. We went on to verify this method with socioeconomic status points, personality points and communication points (SPC points), using consciousness data and profile data collected from a panel on an O2O site. Thus, we showed that innovative buyers could be extracted using this new method, and the accuracy was higher than that of traditional methods measuring only the speed from product sale start to user purchase. Keywords: Innovator Scores, Innovative Buyers, SPC Points, O2O, Cosmopolite Natures, Extraction Model JEL Classifications: M31, O39, C38 DOI: https://doi.org/10.32479/irmm.981

Comparison of glucose monitoring between Freestyle Libre Pro and iPro2 in patients with diabetes mellitus

Aims/Introduction: Flash and continuous glucose monitoring systems are becomingprevalent in clinical practice. We directly compared a flash glucose monitoring system(FreeStyle Libre Pro [FSL-Pro]) with a continuous glucose monitoring system (iPro2) inpatients with diabetes mellitus.Materials and Methods: Glucose concentrations were simultaneously measured usingthe FSL-Pro, iPro2 and self-monitoring blood glucose in 10 patients with diabetes mellitus,and agreement among them was assessed.Results: Parkes error grid analysis showed that the 92.9 and 7.1% of glucose valuesmeasured using the FSL-Pro fell into areas A and B, respectively, and that 96.3, 2.8 and0.9% of those determined using iPro2 fell into areas A, B and C, respectively. The medianabsolute relative differences compared with self-monitoring blood glucose were 8.1%(3.9–12.7%) and 5.0% (2.6–9.1%) for the FSL-Pro and iPro2, respectively. Analysis of 5,555paired values showed a close correlation between FSL-Pro and iPro2 glucose values(q = 0.96, P < 0.01). Notably, 65.3% of all glucose values were lower for the FSL-Pro thanthe iPro2. Median glucose values also decreased by 3.3% for the FSL-Pro compared withthe iPro2 (177.0 [133.0–228.0] vs 183.0 [145.0–230.0] mg/dL, P < 0.01). The difference inglucose values between the two systems was more pronounced in hypoglycemia. Themedian absolute relative difference between FSL-Pro and iPro2 during hypoglycemia wasmuch larger than that during euglycemia and hyperglycemia.Conclusions: Both the FSL-Pro and iPro2 systems are clinically acceptable, but glucosevalues tended to be lower when measured using the FSL-Pro than the iPro2. Agreementwas not close between these systems during hypoglycemia

Genome-Wide Association Study Identifies CDKN1A as a Novel Locus Associated with Muscle Fiber Composition

departmental bulletin pape

Sex-inducing effects toward planarians widely present among parasitic flatworms

Summary Various parasitic flatworms infect vertebrates for sexual reproduction, often causing devastating diseases in their hosts. Consequently, flatworms are of great socioeconomic and biomedical importance. Although the cessation of parasitic flatworm sexual reproduction is a major target of anti-parasitic drug design, little is known regarding bioactive compounds controlling flatworm sexual maturation. Using the planarian Dugesia ryukyuensis, we observed that sex-inducing substances found in planarians are also widespread in parasitic flatworms, such as monogeneans and flukes (but not in tapeworms). Reverse-phase HPLC analysis revealed the sex-inducing substance(s) eluting around the tryptophan retention time in the fluke Calicophoron calicophorum, consistent with previous studies on the planarian Bipalium nobile, suggesting that the substance(s) is likely conserved among flatworms. Moreover, six of the 18 ovary-inducing substances identified via transcriptome and metabolome analyses are involved in purine metabolism. Our findings provide a basis for understanding and modifying the life cycles of various parasitic flatworms.journal articl

Efficacy and safety of single-dose ivermectin in mild-to-moderate COVID-19: the double-blind, randomized, placebo-controlled CORVETTE-01 trial

BackgroundTo investigate whether ivermectin inhibits SARS-CoV-2 proliferation in patients with mild-to-moderate COVID-19 using time to a negative COVID-19 reverse transcription-polymerase chain reaction (RT-PCR) test.MethodsCORVETTE-01 was a double-blind, randomized, placebo-controlled study (August 2020–October 2021) conducted in Japan. Overall, 248 patients diagnosed with COVID-19 using RT-PCR were assessed for eligibility. A single oral dose of ivermectin (200  μg/kg) or placebo was administered under fasting. The primary outcome was time to a negative COVID-19 RT-PCR test result for SARS-CoV-2 nucleic acid, assessed using stratified log-rank test and Cox regression models.ResultsOverall, 112 and 109 patients were randomized to ivermectin and placebo, respectively; 106 patients from each group were included in the full analysis set (male [%], mean age: 68.9%, 47.9 years [ivermectin]; 62.3%, 47.5 years [placebo]). No significant difference was observed in the occurrence of negative RT-PCR tests between the groups (hazard ratio, 0.96; 95% confidence interval [CI] 0.70–1.32; p = 0.785). Median (95% CI) time to a negative RT-PCR test was 14.0 (13.0–16.0) and 14.0 (12.0–16.0) days for ivermectin and placebo, respectively; 82.1% and 84% of patients achieved negative RT-PCR tests, respectively.ConclusionIn patients with COVID-19, single-dose ivermectin was ineffective in decreasing the time to a negative RT-PCR test.Clinical Trial RegistrationClinicalTrials.gov, NCT04703205