7 research outputs found
Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model
- Author
- AG Johansson
- AH Burstein
- AH Reddi
- AK Majors
- AK Topaloglu
- B Bak
- B Lubec
- C Rey
- CH Hill
- CI Levene
- CM Gundberg
- DEC Cole
- DEC Cole
- DEC Cole
- DM Spengler
- DP Brenton
- E Canalis
- EM Spencer
- F Hutterer
- F Parrot
- GK Hunter
- H Schedewie
- HP Klug
- HS Sandhu
- IP Hargreaves
- J Cordey
- J Evrovski
- JC Schwander
- JD Mahuren
- JL Ferretti
- JL Ferretti
- KN Maclean
- KR Wilmarth
- KS McCully
- KS McCully
- L Modis
- LC Gerstenfeld
- LE Church
- M Fritzer-Szekeres
- M Watanabe
- MC van der Meulen
- ME Borgers
- MW Orth
- MW Orth
- MW Orth
- NP Camacho
- OG Isaksson
- P Clopath
- PG Masse
- PG Masse
- PG Masse
- PG Masse
- PG Masse
- PH Rolland
- PV Hauschka
- RE Pyeritz
- RF Pereira
- SH Mudd
- SH Mudd
- SM Han
- X Zhao
- Publication venue
- BioMed Central
- Publication date
- 01/01/2003
- Field of study
BACKGROUND: Classical homocystinuria is an autosomal recessive disorder caused by cystathionine ÎČ-synthase (CBS) deficiency and characterized by distinctive alterations of bone growth and skeletal development. Skeletal changes include a reduction in bone density, making it a potentially attractive model for the study of idiopathic osteoporosis. METHODS: To investigate this aspect of hyperhomocysteinemia, we supplemented developing chicks (n = 8) with 0.6% dl-homocysteine (hCySH) for the first 8 weeks of life in comparison to controls (n = 10), and studied biochemical, biomechanical and morphologic effects of this nutritional intervention. RESULTS: hCySH-fed animals grew faster and had longer tibiae at the end of the study. Plasma levels of hCySH, methionine, cystathionine, and inorganic sulfate were higher, but calcium, phosphate, and other indices of osteoblast metabolism were not different. Radiographs of the lower limbs showed generalized osteopenia and accelerated epiphyseal ossification with distinct metaphyseal and suprametaphyseal lucencies similar to those found in human homocystinurics. Although biomechanical testing of the tibiae, including maximal load to failure and bone stiffness, indicated stronger bone, strength was proportional to the increased length and cortical thickness in the hCySH-supplemented group. Bone ash weights and IR-spectroscopy of cortical bone showed no difference in mineral content, but there were higher Ca(2+)/PO(4)(3- )and lower Ca(2+)/CO(3)(2- )molar ratios than in controls. Mineral crystallization was unchanged. CONCLUSION: In this chick model, hyperhomocysteinemia causes greater radial and longitudinal bone growth, despite normal indices of bone formation. Although there is also evidence for an abnormal matrix and altered bone composition, our finding of normal biomechanical bone strength, once corrected for altered morphometry, suggests that any increase in the risk of long bone fracture in human hyperhomocysteinemic disease is small. We also conclude that the hCySH-supplemented chick is a promising model for study of the connective tissue abnormalities associated with homocystinuria and an important alternative model to the CBS knock-out mouse
Effect of orally administered hydrocortisone on intraocular pressure in nonglaucomatous dogs
- Author
- Akduman L
- Anselmi P
- Armaly MF
- Armaly MF
- Bayer JM
- Bernstein HN
- Blumenthal M
- Cantrill HL
- Covell LL
- Fingert JH
- Forrester SD
- Gelatt KN
- Gelatt KN
- Godel V
- Haas JS
- Jacob E
- Johnson D
- Keates EU
- Kimura R
- Kimura R
- Levene RZ
- Lorenzetti OJ
- Miller PE
- Opatowsky I
- Palkama A
- Rice SW
- Rohen JW
- Sheridan PT
- Skuta GL
- Stern JJ
- Tripathi RC
- Tripathi RC
- Wood DC
- Zhan GL
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Baruch Spinoza: Democracy and Freedom of Speech
- Author
- A Matheron
- A Matheron
- A Negri
- A NĂŠss
- A NĂŠss
- A. Tosel
- C Santinelli
- D Den Uyl
- D Den Uyl
- E Balibar
- E Curley
- F Akkerman
- F Freudenthal
- F Pollock
- G Belaief
- G Crapulli
- G Deleuze
- G Deleuze
- G FassĂČ
- G Lloyd
- G Totaro
- HG Hubbeling
- I Kajanto
- J Préposiet
- J Wetlesen
- J Wetlesen
- J Wetlesen
- KN Levene
- L Althusser
- M Gueret
- P Macherey
- PF Moreau
- R Bodei
- R Misrahi
- R Scruton
- RJ McShea
- S Nadler
- S Zac
- S Zac
- S Zac
- V Morfino
- W Bartuschat
- W Bartuschat
- W Goetschel
- W Montag
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cerebral Hemorrhage
- Author
- A Heep
- A Herbst
- A Kaiser
- A Messerschmidt
- A Messerschmidt
- A Spinillo
- A Whitelaw
- A Whitelaw
- A Whitelaw
- AA Alfenvan der Velden
- AC Mol de
- AJ Brouwer
- AM Heuchan
- AR Synnes
- AS Soraisham
- B Larroque
- B Schmidt
- BP Murphy
- BR Vohr
- C Dani
- C HĂ€rtel
- C Limperopoulos
- C Limperopoulos
- C Limperopoulos
- C Vavasseur
- CA Crowther
- CB Looney
- CR Kennedy
- D Roberts
- D Uchil
- DA Osborn
- DG Batton
- DM Moody
- DR Harding
- E Fernell
- E Roze
- E Roze
- EF Maalouf
- EH Roland
- EK Persson
- F Correa
- FM Cowan
- GE Hardart
- GJ Hofmeyr
- GT Vasileiadis
- H Bassan
- H Bassan
- H Rabe
- HS Ghazi-Birry
- HY Chang
- J Armstrong-Wells
- J Burstein
- J Dudink
- J Fabres
- JA Thorp
- JB Bodensteiner
- JB Bussel
- JB Bussel
- JD Merrill
- JJ Pomerance
- JJ Volpe
- JJ Volpe
- JS Mercer
- JS Soul
- JS Soul
- JT Wells
- K Kersbergen
- K Kuban
- K Patra
- K SĂ€vman
- KE Pape
- KG Palmer
- KJ Rademaker
- KN Haque
- L Srinivasan
- LJ Jocelyn
- LM Chadwick
- LR Ment
- LR Ment
- LR Ment
- LR Ment
- LS Vries de
- LS Vries de
- LS Vries de
- LS Vries De
- M Gleissner
- M Olischar
- M Staudt
- M Tsuji
- MI Levene
- MW Davies
- N Modi
- N Paneth
- O Baud
- O Khwaja
- P Andre
- P Govaert
- PW Fowlie
- RA Kilani
- RL Sherlock
- S Chamnanvanakij
- S Sarkar
- S Takashima
- SE Hamrick
- SJ Counsell
- SJ Gould
- SJ Steggerda
- SJ Steggerda
- ST Dale
- T Dolfin
- T Schmitz
- TD Yanowitz
- U Felderhoff-Mueser
- Ventriculomegaly Trial Group
- W Göpel
- WC Hanigan
- WJ Morales
- YW Wu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2012
- Field of study
Invited Review: Selection of Optimal Lipid Sources in Enteral and Parenteral Nutrition
- Author
- Alexander JW
- Alexander JW
- Allardyce DB
- Angelillo VA
- Askanazi J.
- Baba N.
- Bach A.
- Bach AC
- Ball MJ
- Ball MJ
- Barr LH
- Beisel WR
- Bell SJ
- Berdanier CD
- Berry EM
- Birkhan RH
- Bittiner SB
- Bjerve KS
- Bjerve KS
- Bjorneboe A.
- Bremer J.
- Burr GO
- Caldwell MD
- Campbell AN
- Capital City Products Bulletins.
- Carlson SE
- Carroll KK
- Cerra FB
- Chan PC
- Cleland LG
- Coombes EJ
- Covelli HD
- Crowe PJ
- Cummings JH
- Cummings JH
- Demigne C.
- Dennison AR
- DiLuzio NR
- Dyerberg J.
- Dyerberg J.
- Dyerberg J.
- Eckart J.
- Eckart J.
- Eckart J.
- Elsen RJ
- Erickson KL
- Fischer GW
- Fiser RH
- Flaten H.
- Fleming CR
- Francis DMA
- Freidman Z.
- Gogos C.
- Goodenough RD
- Goodgame JT
- Goodwin JS
- Gottschlich MM
- Gottschlich MM
- Gottschlich MM
- Grancher D.
- Green P.
- Greene HL
- Hamawy KJ
- Hamawy KJ
- Hansen AE
- Harada E.
- Harig JM
- Harkins RW
- Harris WS
- Hashim SA
- Heird WC
- Hepburn FN
- Herold PM
- Herve P.
- Hessor I.
- Hirono H.
- Holman RT
- Holt PR
- Hornstra G.
- Hulsey TK
- Jeejeebhoy KN
- Jelenko C.
- Jensen GL
- Johnson RC
- Johnston DV
- Jurkowski JJ
- Karmali RA
- Katz DP
- Kelley VE
- Kinsella JE
- Kinsella JE
- Kinsella JE
- Knapp HR
- Kohelet D.
- Kolb S.
- Koruda MJ
- Koruda MJ
- Koruda MJ
- Kremer JM
- Kripke SA
- Kromhout D.
- Kuo PT
- Kuo PT
- Kvietys PR
- Ladisch S.
- Landgraf-Leurs MMC
- Lanser ME
- Leaf A.
- Lee TH
- Levene MJ
- Ling PR
- Long JM
- Lowell JA
- Lyte M.
- Macfie J.
- Maiz A.
- Maiz A.
- Marcus AJ
- Mascioli EA
- Mascioli EA
- Mascioli EA
- McCarthy MC
- McHugh MI
- Meguid MM
- Merrill AH
- Mertin J.
- Michele M. Gottschlich
- Miles JM
- Mitsuyoshi K.
- Mochizuki H.
- Mok KT
- Muller JM
- Nakagawa M.
- Nanni G.
- Nanni G.
- Nanni G.
- Needleman P.
- Nettleton JA
- Neuringer M.
- Neuringer M.
- Neuringer M.
- Nordenstrom J.
- Nugent KM
- Nyman M.
- Ota DM
- Palmblad J.
- Paulsrud JR
- Peck MD
- Perez RV
- Perez RV
- Phillipson BE
- Pomposelli JJ
- Prickett JD
- Prickett JD
- Prickett JD
- Rebouche CJ
- Richardson TJ
- Riella MC
- Robin AP
- Roediger WEW
- Rolandelli RH
- Rombeau JL
- Ruppin DC
- Ruppin H.
- Sailer D.
- Saito H.
- Sakata T.
- Salo M.
- Sanders TAB
- Sanders TAB
- Sax HC
- Schaap GH
- Schaffer HKE.
- Seidner DL
- Settle RG
- Shaw JHF
- Shizgal HM
- Simopoulos AP
- Sorbrado J.
- Strunk RC
- Strunk RC
- Sundstrom G.
- Talbott GD
- Tashiro T.
- Trocki O.
- Tulikoura I.
- Tulikoura I.
- Venus B.
- Venus B.
- White HB
- Winawer SJ
- Wolfe BM
- Wolfe RR
- Woolfson AMJ
- Worthley LIG
- Yamazaki K.
- Yang MG
- Yeh YY
- Ziboh VA
- Zurier RB
- Publication venue
- 'SAGE Publications'
- Publication date
- Field of study
ViskositÀt
- Author
- A Artemcenko
- A Baader
- A Bak
- A Banchettr
- A Banchettr
- A Bartoli
- A Bartoli
- A Bearden
- A Bestelmeyer
- A Bestelmeyer
- A Bienas
- A Bienas
- A Bock de
- A Boek
- A Bramley
- A Broese Groeneu van
- A Camerton
- A Campetti
- A Crozier
- A Dietzel
- A Einstein
- A Einstein
- A Emmerich
- A Findlay
- A Fortier
- A Fortier
- A Gille
- A Gorke
- A Heydweiller
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Itterbeek
- A Jaumotte
- A Jaumotte
- A Jobling
- A Jobling
- A Kanitz
- A Klemenc
- A Knappworst
- A Knappworst
- A Kolossowski
- A Korosi
- A Kryagowa
- A Kundt
- A Königer
- A Leontyewa
- A Maman
- A Michels
- A Michels
- A Michels
- A Michels
- A Napolitano
- A Naumowa
- A Pisarew
- A Pochettino
- A Röder
- A Sachanow
- A Sakhanow
- A Schmidt
- A Sellerie
- A Simon
- A Smits
- A Sprung
- A Swinarski
- A Swinarski
- A Timidei
- A Troyer
- A Troyer
- A Troyer De
- A Wijkander
- AA Blanchard
- AA Blanchard
- AA Glagolewa
- AA Mamedow
- AA Romanow
- AA Wertman
- AA Wostryakow
- AA Zalikin
- AB Bdanowskiáż
- AB Cleave
- AB Cleave
- AB Garrett
- AB Garrett
- AC Chatterji
- AC Hollis-Hallett
- AC Hollis-Hallett
- AC Ling
- AC Rocce
- ACD Rivett
- AD Abbott
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Dunstan
- AE Luckiy
- AE Luckiy
- AE Schuir
- AE Stearn
- AF Benning
- AF Schmelzle
- AG Amelin
- AG Amelin
- AG Bergman
- AG Clarke
- AG Mussel
- AG Nasini
- AG Nasini
- AG Nasini
- AH Campbell
- AJ Anderson
- AJ Barlow
- AJ Batschinski
- AJ Batschinski
- AJ Batschinski
- AJ Deitsch
- AJ Lewis
- AJ Rabinowitsch
- AJ Teller
- AJ Wyk Van der
- AK Barua
- AK Doolittle
- AK Mukherjee
- AK Par
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- AK Ray
- AL Day
- AL Lee
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- AO Rankine
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- AP Masia
- AP Mills
- AP Toropow
- AR Barbour
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- AS Chacravarti
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- AS Golik
- AS Golik
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- AS Kertes
- AS Smith
- AS Äernyak
- AV Grosse
- AV Obermayer
- AW Koch
- AW Pamfilow
- AW Pamfilow
- AW Porter
- AW Ralston
- AW Schmidt
- AW Schmidt
- AY DeiÄ
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- B Cornils
- B Latto
- B Longtin
- B Rossmann
- B Tartakowskaya
- B Toplei
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- BD Steele
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- BE Eakin
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- C Antoine
- C Barbe
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- CT Archer
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- D Clifton
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- E André
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- Y Suga
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- YAL Dutcak
- YAL Dutcak
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- YM Ping
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- YP Gokhstein
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- YS Chiong
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- YY Fialkow
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- Z FriedlÀnder
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- Z Reyer
- ZW Kondratenko
- ZW Wolkowa
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2013
- Field of study
In Vivo Imaging in Neurodegenerative Diseases
- Author
- A Antonini
- A Cagnin
- A Ciarmiello
- A Drzezga
- A Feigin
- A Miyawaki
- A Nagano-Saito
- A Nordberg
- A Otte
- A Schmidt
- AC Ludolph
- AC Ludolph
- AJ Vincent
- AL Alexander
- AL Bokde
- AL Phinney
- AM Catafau
- AN Yaroslavsky
- AS Gonul
- AT Toosy
- B Fischl
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