García, Xavier (ed.) (2015). Joan Oliver-Joaquim Molas: Diàleg epistolar il·lustrat (1959-1982). Lleida: Pagès Editors, pp. 186

<p><i>Objectives</i>: Attention-deficit/hyperactivity disorder (ADHD) has been associated with spatial working memory as well as frontostriatal core deficits. However, it is still unclear how the link between these frontostriatal deficits and working memory function in ADHD differs in children and adults. This study examined spatial working memory in adults and children with ADHD, focussing on identifying regions demonstrating age-invariant or age-dependent abnormalities. <i>Methods</i>: We used functional magnetic resonance imaging to examine a group of 26 children and 35 adults to study load manipulated spatial working memory in patients and controls. <i>Results</i>: In comparison to healthy controls, patients demonstrated reduced positive parietal and frontostriatal load effects, i.e., less increase in brain activity from low to high load, despite similar task performance. In addition, younger patients showed negative load effects, i.e., a decrease in brain activity from low to high load, in medial prefrontal regions. Load effect differences between ADHD and controls that differed between age groups were found predominantly in prefrontal regions. Age-invariant load effect differences occurred predominantly in frontostriatal regions. <i>Conclusions</i>: The age-dependent deviations support the role of prefrontal maturation and compensation in ADHD, while the age-invariant alterations observed in frontostriatal regions provide further evidence that these regions reflect a core pathophysiology in ADHD.</p

Additional file 2: Table S2a. of High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder

Rare CNVs discovered in the paediatric obsessive compulsive disorder (OCD) patients; and inheritance pattern in cases with available parents. Table S2b. Rare CNVs discovered in the population control cohort. (PDF 236 kb

Additional file 3: Table S3a. of High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder

According to Pathway Studio. Table S3b. According to DAVID. (PDF 115 kb

Additional file 1: Table S1. of High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder

Comorbidities according to ICD-10 of the pediatric OCD cohort. (DOCX 13 kb

Additional file 4: Table S4. of High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder

(a) CNV burden analysis results from PLINK. The p-values shown are for the GCNT test statistic from PLINK’s cnv-enrichment-test algorithm, applied to the particular gene list versus the entire genome. Although Brain expressed and ID genes resulted in p values below 0.05, only the brain-expressed genes list remains significantly enriched in CNVs after correction for multiple testing (6 tests). (b) CNV burden analysis results from PLINK. The Gene List used. (PDF 1722 kb